1021340-56-6Relevant academic research and scientific papers
Low-Pressure Cobalt-Catalyzed Enantioselective Hydrovinylation of Vinylarenes
Movahhed, Sohajl,Westphal, Julia,Dindaro?lu, Mehmet,Falk, Anna,Schmalz, Hans-Günther
, p. 7381 - 7384 (2016/05/24)
An efficient and practical protocol for the enantioselective cobalt-catalyzed hydrovinylation of vinylarenes with ethylene at low (1.2 bar) pressure has been developed. As precatalysts, stable [L2CoCl2] complexes are employed that are activated in situ with Et2AlCl. A modular chiral TADDOL-derived phosphine-phosphite ligand was identified that allows the conversion of a broad spectrum of substrates, including heterocyclic vinylarenes and vinylferrocene, to smoothly afford the branched products with up to 99 % ee and virtually complete regioselectivity. Even polar functional groups, such as OH, NH2, CN, and CO2R, are tolerated.
Cobalt-catalysed asymmetric hydrovinylation of 1,3-dienes
Timsina, Yam N.,Sharma, Rakesh K.,Rajanbabu
, p. 3994 - 4008 (2015/06/25)
In the presence of bidentate 1,n-bis-diphenylphosphinoalkane-CoCl2 complexes {Cl2Co[P ～ P]} and Me3Al or methylaluminoxane, acyclic (E)-1,3-dienes react with ethylene (1 atmosphere) to give excellent yields of hydrovinylat
A novel catalytic asymmetric route towards skipped dienes with a methyl-substituted central stereogenic carbon
Huang, Yange,Fananas-Mastral, Martin,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 3309 - 3311 (2013/06/04)
A highly efficient method for the enantioselective synthesis of 1,4-dienes (skipped dienes) with a methyl-substituted central stereogenic carbon using copper-catalysed asymmetric allylic alkylation of diene bromides was developed. Excellent regio- and enantioselectivity (up to 97 : 3 SN2′/ SN2 ratio and 99% ee) were achieved with broad substrate scope. The Royal Society of Chemistry 2013.
Bidentate hydroxyalkyl NHC ligands for the copper-catalyzed asymmetric allylic substitution of allyl phosphates with grignard reagents
Magrez, Magaly,Le Guen, Yann,Basle, Olivier,Crevisy, Christophe,Mauduit, Marc
supporting information, p. 1199 - 1203 (2013/02/25)
Demonstrating their potential: Bidentate alkoxy NHC ligands have been used in the copper-catalyzed asymmetric allylic alkylation of allyl phosphates with Grignard reagents (see scheme). The method provides access to tertiary and quaternary chiral centers with high regio- and enantioselectivity. The system is also applied to the synthesis of chiral E,E-dienes, a key structural motif prevalent in natural products. Copyright
