102236-22-6

Basic information

• Product Name: 1-Chloro-2-ethoxy-4-nitrobenzene
• Synonyms: 1-Chloro-2-ethoxy-4-nitrobenzene
• CAS NO: 102236-22-6
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.60702
• Mol File: 102236-22-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Chloro-2-ethoxy-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-2-ethoxy-4-nitrobenzene(102236-22-6)
• EPA Substance Registry System: 1-Chloro-2-ethoxy-4-nitrobenzene(102236-22-6)

Safety Data

• Hazardous Substances Data: 102236-22-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-chloro-2-ethoxy-4-nitrobenzene is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex organic molecules that can exhibit therapeutic properties.
Used in Dye Industry:
In the dye industry, 1-chloro-2-ethoxy-4-nitrobenzene is used as a precursor in the production of dyes, where its chemical structure can be manipulated to create a range of colorants for different applications.
Used in Organic Compounds Synthesis:
1-chloro-2-ethoxy-4-nitrobenzene is utilized as a building block in the synthesis of other organic compounds, where its functional groups can be further modified to achieve desired chemical properties.
It is crucial to handle 1-chloro-2-ethoxy-4-nitrobenzene with care due to its potential to cause irritation to the skin, eyes, and respiratory system, as well as possible damage to the liver and kidneys. Adequate safety measures should be implemented during its use to mitigate these risks.

Upstream product

• 16383-89-4 5-nitro-2-amino-phenetole 
• 171111-66-3 4-ethoxy-5-chloro-2-nitro-aniline 
• 89981-33-9 3-Chlor-2-aethoxy-5-nitro-anilin 
• 581-08-8 2'-ethoxyacetanilide 
• 108761-49-5 acetic acid-(4-ethoxy-3-chloro-anilide) 
• 116496-76-5 4-acetamido-3-ethoxynitrobenzene 
• 861086-20-6 acetic acid-(4-ethoxy-5-chloro-2-nitro-anilide) 
• 94-70-2 ortho-phenitidine 
• 97-02-9 2,4-Dinitroanilin 
• 619-10-3 5-nitro-2-chlorophenol 
• 75-03-6 ethyl iodide 
• 78-10-4 tetraethoxy orthosilicate 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 

Downstream Products

• 619-10-3 5-nitro-2-chlorophenol 
• 85259-46-7 4-chloro-3-ethoxy-benzaldehyde 
• 85259-09-2 (E)-3-(4-Chloro-3-ethoxy-phenyl)-acrylic acid 
• 85258-92-0 5-(4-Chloro-3-ethoxy-phenyl)-thiazolidine-2,4-dione 
• 64046-47-5 2-chloro-5-nitrophenyl acetate 
• 852854-42-3 4-chloro-3-ethoxyphenylamine 

Relevant articles and documents

Synthesis of aryl ethers from aromatic carboxylic acids

A silver/copper bimetallic catalyst system promotes the decarboxylative Chan-Evans-Lam alkoxylation of ortho-substituted aromatic carboxylate salts with tetraalkyl orthosilicates or triaryl borates. Non-ortho-substituted carboxylates are alkoxylated via an ortho-C-H-alkoxylation with concomitant cleavage of the carboxylate directing group via protodecarboxylation. This way, meta-substituted carboxylates are converted into para-substituted alkoxyarenes and vice versa. The combined processes provide a convenient synthetic entry to the important class of aromatic ethers from widely available carboxylic acids.

Decarboxylative etherification of aromatic carboxylic acids

Decarboxylative Chan-Evans-Lam-type couplings are presented as a new strategy for the regiospecific construction of diaryl and alkyl aryl ethers starting from easily available aromatic carboxylic acids. They allow converting various aromatic carboxylate salts into the corresponding aryl ethers by reaction with alkyl orthosilicates or aryl borates, under aerobic conditions in the presence of silver carbonate as the decarboxylation catalyst and copper acetate as the cross-coupling catalyst.

BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).