102729-42-0

Basic information

• Product Name: Quinoxaline, 2-phenyl-7-(trifluoromethyl)-
• CAS NO: 102729-42-0
• Molecular Formula: C15H9F3N2
• Molecular Weight: 274.245
• Mol File: 102729-42-0.mol

Chemical Properties

• CAS DataBase Reference: Quinoxaline, 2-phenyl-7-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoxaline, 2-phenyl-7-(trifluoromethyl)-(102729-42-0)
• EPA Substance Registry System: Quinoxaline, 2-phenyl-7-(trifluoromethyl)-(102729-42-0)

Safety Data

• Hazardous Substances Data: 102729-42-0(Hazardous Substances Data)

Upstream product

• 1074-12-0 phenylglyoxal hydrate 
• 368-71-8 4-(trifluoromethyl)-1,2-phenylenediamine 
• 35549-90-7 β-(2-Amino-4-trifluoromethyl)-phenylaminobutansaeure 
• 532-54-7 oxo-phenyl-acetaldehyde oxime 
• 35549-89-4 β-(2-Nitro-4-trifluoromethyl)-phenylaminobutansaeure 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 536-74-3 phenylacetylene 
• 122-78-1 phenylacetaldehyde 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 

Downstream Products

• 102729-54-4 3-phenyl-6-trifluoromethylquinoxaline 1-oxide 

Relevant articles and documents

Iridium-Catalyzed [4+2] Annulations of β-Keto Sulfoxonium Ylides and o-Phenylenediamines: Mild and Facile Synthesis of Quinoxaline Derivatives

A synthetic method for quinoxaline derivatives from the [4+2] annulation of β-keto sulfoxonium ylides and o-phenylenediamine by using (Cp*IrCl2)2 catalyst is described. This novel protocol features mild reaction conditions, moderate to excellent yields, wide substrate scope, and high functional-group compatibility. Moreover, this cyclization strategy was successfully applied in late-stage modification for structurally complex bioactive compounds.

Synthesis of 2-arylquinoxalines: Triarylstibane-catalyzed oxidative cyclization of α-hydroxy ketones with 1,2-diamines under aerobic conditions

The reaction of α-hydroxy ketones with 1,2-diamines in the presence of triphenylstibane (10 mol%) as catalyst led to the formation of 2-arylquinoxalines in moderate to good yield under aerobic conditions. This reaction is the first example of oxidative cy

One-pot copper-catalyzed three-component synthesis of quinoxalines by condensation and C-N bond formation

A novel way of synthesizing quinoxalines has been developed that involves condensation and C-N bond formation in a copper-catalyzed, one-pot, three-component reaction. The reaction was optimized when 2-iodoanilines (1.0 equiv), arylacetaldehydes (2.0 equiv), sodium azide (1.2 equiv), CuI (10 mol%), DMEDA (10 mol%), and K2CO3 (1.0 equiv) were reacted in DMSO at 80 °C for 20 hours. This approach was used to directly synthesize a variety of quinoxalines in moderate to good yields. Georg Thieme Verlag KG Stuttgart.

Gold-catalyzed synthesis of glyoxals by oxidation of terminal alkynes: One-pot synthesis of quinoxalines

From terminal alkynes to glyoxals: Terminal alkynes can be oxidized under mild conditions by the use of an N-oxide in the presence of a gold catalyst. The intermediate glyoxal derivatives can be transferred in a one-pot procedure to substituted quinoxalines (see scheme). Copyright

2-Phenyl-(6(7)-R-substituted quinoxalines N-oxides. Synthesis, structure elucidation and antimicrobial activity

A certain number of isomeric 2-phenylquinoxalines N-oxides bearing substituents at position 6/7 were prepared in order to investigate anti-microbial activity. The effect of some electron-withdrawing groups seem to increase an anti-Trichomonas vaginalis ac