103261-70-7

Basic information

• Product Name: 5-Benzothiazolecarboxylicacid,ethylester(6CI,9CI)
• Synonyms: 5-Benzothiazolecarboxylicacid,ethylester(6CI,9CI);5-Benzothiazolecarboxylicacid,ethylester
• CAS NO: 103261-70-7
• Molecular Formula: C₁₀H₉NO₂S
• Molecular Weight: 207.252
• Product Categories: BENZOTHIAZOLE
• Mol File: 103261-70-7.mol

Chemical Properties

• Boiling Point: 322.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.290±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.05±0.10(Predicted)
• CAS DataBase Reference: 5-Benzothiazolecarboxylicacid,ethylester(6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzothiazolecarboxylicacid,ethylester(6CI,9CI)(103261-70-7)
• EPA Substance Registry System: 5-Benzothiazolecarboxylicacid,ethylester(6CI,9CI)(103261-70-7)

Safety Data

• Hazardous Substances Data: 103261-70-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Benzothiazolecarboxylic acid, ethyl ester (6CI, 9CI) is used as a building block in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Benzothiazolecarboxylic acid, ethyl ester (6CI, 9CI) serves as a key component in the creation of agrochemicals, aiding in the development of products designed to protect crops and enhance agricultural productivity.
Used in Dye Industry:
5-Benzothiazolecarboxylic acid, ethyl ester (6CI, 9CI) is utilized in the dye industry as a crucial intermediate in the production of various dyes, contributing to the coloration and performance of these products.
Used in Anticancer Applications:
5-Benzothiazolecarboxylic acid, ethyl ester (6CI, 9CI) is employed as a potential anticancer agent, leveraging its reported anticancer properties to contribute to the development of novel treatments for various types of cancer.
Used in Antimicrobial Applications:
5-Benzothiazolecarboxylicacid,ethylester(6CI,9CI) is also used in antimicrobial applications, capitalizing on its antimicrobial properties to develop products that can combat microbial infections and contribute to public health.
Used in Laboratory Research and Diagnostic Applications:
5-Benzothiazolecarboxylic acid, ethyl ester (6CI, 9CI) is used as a fluorescence indicator in laboratory research and diagnostic applications, providing a valuable tool for visualizing and studying various biological processes and conditions.

Upstream product

• 64-18-6 formic acid 
• 49568-47-0 3,3'-dinitro-4,4'-disulfanediyl-di-benzoic acid diethyl ester 
• 140-88-5 ethyl acrylate 
• 206662-96-6 4,5-bis(dibromomethyl)thiazole 

Downstream Products

• 68867-17-4 1,3-benzothiazole-5-carboxylic acid 
• 103040-92-2 2-amino-5-ethoxycarbonylbenzothiazole 
• 394223-38-2 1,3-benzothiazole-5-carbaldehyde 

Relevant articles and documents

Generation and Diels-Alder trapping of 4,5-bis(bromomethylene)-4,5-dihydrothiazole

Treatment of 4,5-bis(dlbromomethyl)thiazole (1a) with sodium iodide in DMF led to 4,5-bis(bromomethylene)-4,5-dihydrothiazole (2a). Trapping the latter in situ with dienophiles afforded directly the aromatized cycloadducts. Starting with 5-hydroxynaphthoquinone or its 2- and 3-bromo derivatives 6 gave a mixture of the tetracyclic quinones 10 + 11 from which the 1,6-regioisomer 10 predominates. Using acrylate dienophiles gave 6-substituted benzothiazoles 13 as the major products. The regiochemistry of the cycloadditions between 2a and naphthoquinones 6 agrees with the predictions of the frontier molecular orbital theory. In contrast, the regioselectivity observed from 2a and acrylate dienophiles 12, similar to that previously obtained with 5-bromomethylene-4-methylene-4,5-dihydrothiazole (2b), is opposite to that predicted and could be better accomodated by a competitive Michael addition followed by a cyclization-elimination step.

INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

ANABASEINE DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

The compounds of the present invention are of formula (I): wherein A, R3, R4 is as defined herein, are useful as ligands for nicotinic receptors.

INDAZOLES, BENZOTHIAZOLES, AND BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.