103281-33-0

Basic information

• Product Name: 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone
• Synonyms: 2,2-Bis(4-Methoxyphenyl)-1,2-diphenylethanone;2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone
• CAS NO: 103281-33-0
• Molecular Formula: C₂₈H₂₄O₃
• Molecular Weight: 408.48836
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 103281-33-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone(103281-33-0)
• EPA Substance Registry System: 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone(103281-33-0)

Safety Data

• Hazardous Substances Data: 103281-33-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone is used as an intermediate in the preparation of Clomiphene (C587025) impurity. Clomiphene is a medication primarily used to treat infertility in women, and 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone plays a crucial role in the synthesis process to ensure the purity and efficacy of the final product.
As an intermediate, 2,2-Bis(p-Methoxyphenyl)-2-phenylacetophenone contributes to the development of pharmaceuticals by facilitating the synthesis of specific compounds with desired therapeutic properties. Its chemical structure allows for further functionalization and modification, making it a versatile building block in the synthesis of various pharmaceutical agents.

Upstream product

• 611-94-9 4-Methoxybenzophenone 
• 2443-45-0 1,2-bis(4-methoxyphenyl)-1,2-diphenyl-1,2-ethanediol 
• 367935-16-8 2-hydroxy-2-(4-methoxyphenyl)-1,2-diphenylethanone 
• 100-66-3 methoxybenzene 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 720-44-5 1-(4-methoxyphenyl)-1-phenylmethanol 

Downstream Products

• 103098-60-8 2,2-bis-(4-methoxy-phenyl)-1,2-diphenyl-ethanol 
• 7500-76-7 4,4'-dimethoxytriphenylmethane 
• 65-85-0 benzoic acid 
• 40615-35-8 4,4'-dimethoxytrityl alcohol 

Relevant articles and documents

A highly efficient friedel-crafts reaction of tertiary α- hydroxyesters or α-hydroxyketones to α-quaternary esters or ketones

A catalytic Friedel-Crafts arylation of α-hydroxyesters or α-hydroxyketones with electron-rich aromatic compounds to furnish α-quaternary esters/ketones has been developed. The cheap and easy to handle catalyst HClO4 (70 %, aq) was identified as a powerful catalyst for this arylation reaction. Copyright

Friedel-crafts arylation of α-hydroxy ketones: Synthesis of 1,2,2,2-tetraarylethanones

Friedel-Crafts arylation of α-hydroxy ketones such as 2-hydroxy-1,2,2-triarylethanones has been achieved with a variety of arenes and heteroarenes in the presence of Lewis or Bronsted acids. Both sterically hindered and unhindered 1,2,2,2-tetrarylethanone

Pinacol-Pinacolone Rearrangement on FeCl3 Modified Montmorillonite K10

Pinacol-pinacolone rearrangement was investigated over Fe-modified montmorillonite K10 catalysts in liquid phase. Exceptional activity was found to be associated with FeCl3 impregnated on K10 through its acetonitrile solution. 100% conversion of benzopinacol was observed in 10 minutes. The catalysts are recyclable.