720-44-5

Basic information

• Product Name: 4-METHOXYBENZHYDROL
• Synonyms: Benzenemethanol, 4-methoxy-alpha-phenyl-;4-METHOXYPHENYL PHENYL CARBINOL;(4-METHOXY-PHENYL)-PHENYL-METHANOL;4-METHOXYBENZHYDROL;LABOTEST-BB LT00454002;AURORA KA-7054;4-Methoxydiphenylmethanol~4-Methoxyphenyl phenyl carbinol;4-methoxybenzhydryl alcohol
• CAS NO: 720-44-5
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.26
• EINECS: 211-953-9
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 720-44-5.mol
• Article Data: 302

Chemical Properties

• Melting Point: 67-69°C
• Boiling Point: 363.2 °C at 760 mmHg
• Flash Point: 164.5 °C
• Appearance: /
• Density: 1.121 g/cm³
• Vapor Pressure: 6.55E-06mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.61±0.20(Predicted)
• BRN: 3202445
• CAS DataBase Reference: 4-METHOXYBENZHYDROL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYBENZHYDROL(720-44-5)
• EPA Substance Registry System: 4-METHOXYBENZHYDROL(720-44-5)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 720-44-5(Hazardous Substances Data)

Usage

General Description

4-Methoxybenzhydrol is a chemical compound with the molecular formula C14H14O2. It is a white to off-white solid with a faint odor, and is used in the production of various pharmaceuticals and organic compounds. 4-Methoxybenzhydrol is known for its antioxidant and antibacterial properties, and is commonly used as an intermediate in the synthesis of other chemicals. It is considered to be relatively stable under normal conditions, and is not known to pose any significant health hazards. Overall, 4-Methoxybenzhydrol is an important chemical compound with a wide range of applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C14H14O2/c1-16-13-9-7-12(8-10-13)14(15)11-5-3-2-4-6-11/h2-10,14-15H,1H3

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 611-94-9 4-Methoxybenzophenone 
• 683-60-3 sodium isopropylate 
• 67-63-0 isopropyl alcohol 
• 56-23-5 tetrachloromethane 
• 6731-11-9 4-methoxybenzhydryl chloride 
• 67-64-1 acetone 
• 109-72-8 n-butyllithium 
• 38513-66-5 (phenyl)(p-methoxyphenyl)methanol acetate 
• 940-00-1 (4-methoxyphenyl)trimethylstannane 
• 100-52-7 benzaldehyde 
• 934-56-5 trimethyl(phenyl)stannane 
• 64-17-5 ethanol 
• 7732-18-5 water 

Downstream Products

• 114327-14-9 3-(4-methoxyphenyl)-3-phenylpropanoic acid 
• 855658-50-3 (4-methoxy-benzhydryl)-malonic acid 
• 441-54-3 4-methoxybenzhydryl trifluoroacetate 
• 7500-76-7 4,4'-dimethoxytriphenylmethane 
• 18832-91-2 Oxalsaeure-di-(4-methoxy-benzhydryl-ester) 
• 24677-13-2 N-(4-Methoxy-benzhydryl)-thiobenzamid 
• 7515-72-2 1-[chlorophenylmethyl]-4-nitrobenzene 
• 101402-05-5 (RS)-4-nitro-α-phenylbenzenemethyl acetate 
• 16983-00-9 3--2-hydroxy-1,4-naphthochinon 
• 106116-38-5 (4-Methoxyphenyl)phenylmethylbromid 
• 7732-18-5 water 
• 6731-11-9 4-methoxybenzhydryl chloride 
• 611-94-9 4-Methoxybenzophenone 
• 720-44-5 (R)-(4-methoxyphenyl)phenylmethanol 

Relevant articles and documents

Melamine-Based Porous Organic Polymers Supported Pd(II)-Catalyzed Addition of Arylboronic Acids to Aromatic Aldehydes

Abstract: A new type melamine-based porous organic polymers (SZU-1) has been synthesized with melamine and 2,2′-bipyridyl-5,5′-dialdehyde by a one-pot method and fully characterized. Divalent palladium salts were coordinated to this polymer network which successfully catalyzed the nucleophilic addition reaction of arylboronic acids to aromatic aldehydes. With only 1.0?mol% heterogeneous catalyst loading, high reaction yields (>?85%) can be achieved in most cases. The scope of substrates was also investigated and the catalyst showed universal applicability. Graphic Abstract: The loose and porous melamine-based porous organic polymers (SZU-1) are synthesized by melamine and 2,2′-bipyridyl-5,5′-dialdehyde. The performance of SZU-1 was characterized and most of the substrates achieved high yield (> 85%) in the catalytic performance test.[Figure not available: see fulltext.]

Enantioselective α-Arylation of Primary Alcohols under Sequential One-Pot Catalysis

Secondary benzylic alcohols and diarylmethanols are common structural motifs of biologically active and medicinally relevant compounds. Here we report their enantioselective synthesis by α-arylation of primary aliphatic and benzylic alcohols under sequential catalysis integrating a Ru-catalyzed hydrogen transfer oxidation and a Ru-catalyzed nucleophilic addition. The method can be applied to various alcohols and aryl nucleophiles tolerating a range of functional groups, including secondary alcohols, ketones, alkenes, esters, NH amides, tertiary amines, aryl halides, and heterocycles.

Nickel-Mediated Enantiospecific Silylation via Benzylic C-OMe Bond Cleavage

Benzylic stereocenters are found in bioactive and drug molecules, as enantiopure benzylic alcohols have been used to build such a stereogenic center, but are limited to the construction of a C-C bond. Silylation of alkyl alcohols has the potential to build bioactive molecules and building blocks; however, the development of such a process is challenging and unknown. Herein, we describe an unprecedented AgF-assisted nickel catalysis in the enantiospecific silylation of benzylic ethers.