10364-68-8

Basic information

• Product Name: Oxadiazole, 1,2,4-, 5-ethyl-3-phenyl-,
• Synonyms: Oxadiazole, 1,2,4-, 5-ethyl-3-phenyl-,;5-Ethyl-3-phenyl-1,2,4-oxadiazole
• CAS NO: 10364-68-8
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.199
• Mol File: 10364-68-8.mol

Chemical Properties

• Boiling Point: 294.8 °Cat760mmHg
• Flash Point: 131.2 °C
• Appearance: /
• Density: 1.111g/cm³
• Vapor Pressure: 0.00278mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: Oxadiazole, 1,2,4-, 5-ethyl-3-phenyl-,(CAS DataBase Reference)
• NIST Chemistry Reference: Oxadiazole, 1,2,4-, 5-ethyl-3-phenyl-,(10364-68-8)
• EPA Substance Registry System: Oxadiazole, 1,2,4-, 5-ethyl-3-phenyl-,(10364-68-8)

Safety Data

• Hazardous Substances Data: 10364-68-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10N2O/c1-2-9-11-10(12-13-9)8-6-4-3-5-7-8/h3-7H,2H2,1H3

Upstream product

• 123-62-6 propionic acid anhydride 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 873-67-6 benzonitrile oxide 
• 107-12-0 propiononitrile 
• 932-90-1 Benzaldoxime 
• 54714-12-4 Propionic acid 1,1,4-trioxo-2,5-diphenyl-4,5-dihydro-1H-1λ⁶-thiophen-3-yl ester 
• 613-92-3 N-hydroxyl-benzamidine 
• 802294-64-0 propionic acid 
• 100-47-0 benzonitrile 
• 108-03-2 1-Nitropropane 
• 37467-27-9 5-ethyl-3-phenyl-4,5-dihydro-1,2,4-oxadiazole 
• 3709-18-0 2,2,5-trimethyl-1,3-dioxane-4,6-dione 
• 76670-24-1 O-(N-acetylbenzimidoyl)benzamidoxime 
• 76670-23-0 O-benzimidoylbenzamidoxime 

Downstream Products

• 93323-44-5 5-(1-methyl-2-phenyl-vinyl)-3-phenyl-[1,2,4]oxadiazole 
• 10364-69-9 5-ethyl-3-(3-nitro-phenyl)-[1,2,4]oxadiazole 
• 1430117-97-7 5-[3-(2,6-dichlorophenyl)isoxazol-4-yl]-3-phenyl-1,2,4-oxadiazole 
• 1430117-94-4 dimethyl (E)-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethenylamine 

Relevant articles and documents

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Efficient insecticidal aerosol and preparation method thereof

The invention provides an efficient insecticidal aerosol, which comprises the following components in percentage by weight: 0.1-0.5wt% of a component A, i.e. a 1, 2, 4-diazole derivative shown as a formula I, 1-1.5wt% of a component B, i.e. a marigold ext

Preparation, structure, and versatile reactivity of pseudocyclic benziodoxole triflate, new hypervalent iodine reagent

A new pseudocyclic triflate derivative of benziodoxole (IBA-OTf) was prepared and characterized by X-ray analysis. This highly electrophilic reagent readily reacts with various organic substrates to give the corresponding products in good yields. Furthermore, IBA-OTf can be used as a catalyst with m-chloroperoxybenzoic acid as the terminal oxidant. This journal is

One-pot synthesis of 1,2,4-oxadiazoles from carboxylic acids using 4-(dimethylamino)pyridinium acetate as efficient, regenerable, and green catalyst with ionic liquid character

A recyclable bifunctional acid-base organocatalyst with ionic liquid character has been prepared and its catalytic activity for the preparation of oxadiazoles has been investigated.

Efficient and convenient protocol for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles using HClO4-SiO2 as a heterogeneous recyclable catalyst

Silica-supported perchloric acid (HClO4SiO2) was found to be a new, highly efficient, inexpensive, and reusable catalyst for a rapid and efficient synthesis of various 1,2,4-oxadiazoles with good to excellent yields under solvent-free conditions. The present methodology has been effectively utilized for the synthesis of oxolamine, an anti-inflammatory drug.

Br?nsted acid-catalyzed simple and efficient synthesis of 1,2,4-triazoles and 1,2,4-oxadiazoles using 2,2,2-trichloroethyl imidates in PEG

A facile and highly efficient synthesis of 3,4,5-trisubstituted 1,2,4-triazoles and 3,5-disubstituted 1,2,4-oxadiazoles from 2,2,2-trichloroethyl imidates using PEG as a solvent and employing PTSA as the catalyst under mild conditions is described.

A novel, one-pot, three-component synthesis of 1,2,4-oxadiazoles under microwave irradiation and solvent-free conditions

A novel synthesis of 3,5-disubstituted 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and Meldrum's acids under microwave irradiation and solvent-free conditions in good to excellent yields. Georg

Electrochemical oxidation of substituted amide oximes and 4,5-dihydro-1,2,4-oxadiazoles

The electrooxidation of several substituted amide oximes to yield the corresponding nitriles, alcohols, and imidate was successfully carried out. The reaction products were dependent on the substituents. Additionally, 4,5-dihydro-1,2,4-oxadiazoles derived from amide oximes were electro-oxidized to afford 1,2,4-oxadiazoles in good yields.

A Simplified Procedure for Preparing 3,5-Disubstituted-1,2,4-Oxadiazoles by Reaction of Amidoximes with Acyl Chlorides in Pyridine Solution

3-R-5-R'-1,2,4-Oxadiazoles are prepared in fair to good yield by short-time, one-pot reaction of an amidoxime, RC(NH2)NOH, with an acyl chloride, R'COCl, in pyridine solution.Precipitation of the oxadiazole occurs on diluting the pyridine reaction solutio