37467-27-9Relevant academic research and scientific papers
Δ2-1,2,4-oxadiazolines by condensation of amidoximes with ketones and aldehydes
Lessel
, p. 383 - 389 (1993)
Using acetic acid as a solvent, ketones and aromatic aldehydes react with amidoximes 1 to cyclic products, Δ2-1,2,4-oxadiazolines 3. The lack of reactivity in neutral milieu is explained by MNDO calculations. Protonated carbonyl compounds are discussed to be the reactive species.
Gold-Catalyzed Formal [3 + 2] Cycloaddition of Ynamides with 4,5-Dihydro-1,2,4-oxadiazoles: Synthesis of Functionalized 4-Aminoimidazoles
Xu, Wei,Wang, Gaonan,Sun, Ning,Liu, Yuanhong
supporting information, p. 3307 - 3310 (2017/06/23)
A gold-catalyzed formal [3 + 2] cycloaddition of ynamides with 4,5-dihydro-1,2,4-oxadiazoles has been developed. The reaction provides a concise and regioselective access to highly functionalized 4-aminoimidazoles likely via the formation of an α-imino go
