103914-44-9

Basic information

• Product Name: 6-FLUORO-2-PHENYL-4-QUINOLINOL
• Synonyms: 6-FLUORO-2-PHENYL-4-QUINOLINOL;6-Fluoro-4-hydroxy-2-phenylquinoline
• CAS NO: 103914-44-9
• Molecular Formula: C₁₅H₁₀FNO
• Molecular Weight: 239.24
• Mol File: 103914-44-9.mol

Chemical Properties

• Boiling Point: 389.294°C at 760 mmHg
• Flash Point: 189.238°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 6-FLUORO-2-PHENYL-4-QUINOLINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-2-PHENYL-4-QUINOLINOL(103914-44-9)
• EPA Substance Registry System: 6-FLUORO-2-PHENYL-4-QUINOLINOL(103914-44-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 103914-44-9(Hazardous Substances Data)

Usage

Chemical compound

6-FLUORO-2-PHENYL-4-QUINOLINOL

Classification

Quinolone class of antibiotics

Use

Treatment of various bacterial infections

Composition

Contains a fluorine atom, a phenyl group, and a quinolinol ring structure

Mechanism of action

Inhibits bacterial DNA synthesis by targeting essential enzymes

Spectrum of activity

Broad spectrum against both Gram-negative and Gram-positive bacteria

Caution

Should be used under the guidance of a healthcare professional to avoid resistance and side effects.

InChI:InChI=1/C15H10FNO/c16-11-6-7-13-12(8-11)15(18)9-14(17-13)10-4-2-1-3-5-10/h1-9H,(H,17,18)

Upstream product

• 700-36-7 2-bromo-4-fluoronitrobenzene 
• 536-74-3 phenylacetylene 
• 13939-06-5 molybdenum hexacarbonyl 
• 201230-82-2 carbon monoxide 
• 591751-71-2 4-fluoro-N-(α-methylbenzylidene)aniline 
• 98-86-2 acetophenone 
• 371-40-4 4-fluoroaniline 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 1032315-69-7 6-fluoro-2-phenylquinolin-4-yl-phosphate 
• 103914-45-0 4-chloro-6-fluoro-2-phenylquinoline 
• 1032315-67-5 dibenzyl 6-fluoro-2-phenylquinolin-4-yl-phosphate 

Relevant articles and documents

Supported palladium-catalyzed carbonylative cyclization of 2-bromonitrobenzenes and alkynes to access quinolin-4(1H)-ones

A palladium supported on graphitic carbon nitride (Pd/g-C3N4) catalyzed carbonylative cyclization of 2-bromonitrobenzenes and alkynes has been developed for the expedite construction of quinolin-4(1H)-one scaffolds. By using a low loading heterogeneous palladium catalyst, Mo(CO)6 as both the CO surrogate and the reductant, and nitroarenes as the nitrogen source, the reaction proceeded well to give a variety of quinolin-4(1H)-ones in good to excellent yields.

From Ketones, Amines, and Carbon Monoxide to 4-Quinolones: Palladium-Catalyzed Oxidative Carbonylation

A novel method of palladium-catalyzed oxidative carbonylation of ketones, amines, and carbon monoxide for the synthesis of 4-quinolones has been developed. This protocol provides a straightforward route to construct useful 4-quinolone derivatives from ine

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: Identification as antimitotic agents interacting with tubulin

A series of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds have been synthesized and evaluated as cytotoxic compounds and as antimitotic agents interacting with tubulin. The 2-phenyl-4-quinolones (22-30) with substituents