10553-07-8

Basic information

• Product Name: 1H-Indole, 7-Methyl-4-nitro-
• Synonyms: 1H-Indole, 7-Methyl-4-nitro-;7-Methyl-4-nitro-1H-indole
• CAS NO: 10553-07-8
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17202
• Mol File: 10553-07-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole, 7-Methyl-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 7-Methyl-4-nitro-(10553-07-8)
• EPA Substance Registry System: 1H-Indole, 7-Methyl-4-nitro-(10553-07-8)

Safety Data

• Hazardous Substances Data: 10553-07-8(Hazardous Substances Data)

Usage

Bicyclic heterocyclic organic compound

1H-Indole, 7-methyl-4-nitrois derived from indole, which is a bicyclic (two interconnected rings) heterocyclic (containing different elements) organic compound.

Nitro group at the 4 position

The compound contains a nitro group (-NO2) attached to the 4th position of the indole ring, which can undergo reduction reactions to produce amino derivatives.

Methyl group at the 7 position

A methyl group (-CH3) is attached to the 7th position of the indole ring, which can influence the compound's reactivity and biological properties.

Building block in organic synthesis and pharmaceutical research

1H-Indole, 7-methyl-4-nitrois commonly used as a building block for the synthesis of various biologically active molecules.

Synthesis of biologically active molecules

The compound serves as an intermediate for the development of new drugs and agrochemicals due to its reactivity and potential for modification.

Relevance in pharmaceuticals

Amino derivatives produced from the reduction of the nitro group are often found in pharmaceuticals and biologically active compounds, making this compound valuable for drug development.

Upstream product

• 90771-57-6 7-methyl-4-nitro-indole-2-carboxylic acid 
• 133053-69-7 methyl N-(2,6-dimethyl-3-nitrophenyl)-formimidate 
• 4769-97-5 4-nitro-1H-indoIe 
• 676-58-4 methylmagnesium chloride 
• 67083-28-7 2,6-dimethyl-3-nitroaniline 
• 91559-47-6 7-methyl-4-nitro-indole-2-carboxylic acid ethyl ester 
• 87-62-7 2,6-dimethylaniline 

Downstream Products

• 1000604-35-2 1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-7-methyl-4-nitro-1H-indole 
• 1000605-10-6 1-(3-isopropyl-4-benzyloxybenzoyl)-7-methyl-4-nitro-1H-indole 
• 90868-08-9 4-amino-7-methylindole 

Relevant articles and documents

NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND MEDICAL USE THEREOF

An object of the present invention is to provide a medicament as a thyroid hormone receptor ligand which is sufficient in drug efficacy and safety, and has the excellent action as a drug. The present invention provides a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: [wherein [Chemical Formula 2] is a single bond or a double bond; A is -CH2- or -CO-; X, Y, and Z are each independently a nitrogen atom or a carbon atom; R1 is a hydrogen atom or an aralkyl group; R2 is an alkyl group or an aralkyl group, etc.; R3 is a hydrogen atom or an alkyl group, etc.; R4 is a hydrogen atom or an alkyl group; R5 is a hydrogen atom, an alkyl group or a halo lower alkyl group, etc.; R6 is a hydrogen atom or an alkyl group; R7 is a hydrogen atom, etc.; R8 is a hydrogen atom, or an alkyl group, etc.; and E is -NHCO-G-COR12, etc. (wherein G is a single bond or an alkylene group, and R12 is a hydroxy group or an alkoxy group)].

yDNA: A new geometry for size-expanded base pairs

Room for expansion: Insertion of a benzene ring into the natural adenine heterocycle to generate the analogue yA results in the formation of base pairs that are 2.4 A wider than natural ones (see structure). Melting temperature and free energy data show t

Synthesis of Indoles via Ring Closure of 2-Alkylnitroaniline Derivatives.

A variety of nitroindoles have been prepared from imidate, amidine, and sec-anilide derivatives of 2-alkyl-3- or 5-nitroanilines by a base-induced cyclization promoted by dialkyl oxalates.It is shown that essentially the same procedure also can be used to synthesize the corresponding nitroindole-3-glyoxylates in one simple operation.The synthetic potential is discussed and a mechanism is proposed.