105678-71-5

Basic information

• Product Name: N,N''-BIS-(4-BROMO-PHENYL)-MALONAMIDE
• Synonyms: N,N'-bis(4-bromophenyl)propanediamide
• CAS NO: 105678-71-5
• Molecular Formula: C₁₅H₁₂Br₂N₂O₂
• Molecular Weight: 412.08
• Mol File: 105678-71-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,N''-BIS-(4-BROMO-PHENYL)-MALONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N''-BIS-(4-BROMO-PHENYL)-MALONAMIDE(105678-71-5)
• EPA Substance Registry System: N,N''-BIS-(4-BROMO-PHENYL)-MALONAMIDE(105678-71-5)

Safety Data

• Hazardous Substances Data: 105678-71-5(Hazardous Substances Data)

Upstream product

• 504-64-3 carbon suboxide 
• 106-40-1 4-bromo-aniline 
• 105-53-3 diethyl malonate 
• 861329-81-9 bromo-malonic acid bis-(4-bromo-anilide) 
• 64-19-7 acetic acid 
• 861356-59-4 dibromo-malonic acid bis-(4-bromo-anilide) 
• 13195-64-7 diisopropyl malonate 

Downstream Products

• 861357-13-3 chloro-malonic acid bis-(4-bromo-anilide) 
• 861329-81-9 bromo-malonic acid bis-(4-bromo-anilide) 
• 676642-91-4 hydroxyimino-malonic acid bis-(4-bromo-anilide) 
• 105678-75-9 N¹,N³-Bis-(4-bromo-phenyl)-2,2-dichloro-propanediimidoyl dichloride 
• 138574-50-2 2,2-Diamino-N,N'-bis-(4-bromo-phenyl)-malonamide 
• 105678-70-4 C₁₅H₁₀Br₂N₈ 
• 105698-86-0 C₁₅H₈Br₂Cl₂N₈ 
• 138574-56-8 N,N'-Bis-(4-bromo-phenyl)-2-imino-malonamide 

Relevant articles and documents

One-pot synthesis of 2,3-bis-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)succinates and arylmethylene-bis-3,3′-quinoline-2-ones

Abstract: In this investigation an efficient synthesis of 2,3-bis-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)succinic acid derivatives was achieved by one-pot reaction of one equivalent of aromatic amines with two equivalents of diethyl malonate in dipheny

METHODS AND COMPOSITIONS FOR INHIBITION OF BROMODOMAIN AND EXTRATERMINAL PROTEINS

The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using

METHODS AND COMPOSITIONS FOR INHIBITION OF BROMODOMAIN-CONTAINING PROTEINS

The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.

Isopropyl N-arylmalonamates. Synthesis, structure, conformation and reactions with carbon disulfide

Acylation of aromatic amines 1 with diisopropyl malonate (2) leads to a mixture of isopropyl N-arylmalonamates 3 and malonanilides 4. The reaction of 3 with carbon disulfide in the presence of sodium hydride gives disodium salts 5. Treatment of 5 with an alkylating agent yields the open-chain or cyclic ketene dithioacetals 6, 7 or 8. The molecular structure, hydrogen bonding and preferential conformation of the isopropyl N-arylmalonamates 3, 6 and 7 were investigated using correlation analyses of IR, 13C NMR and AMI semiempirical data.