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1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI) is an organic compound with the molecular formula C8H6N2O2. It is a derivative of benzimidazole, a heterocyclic compound consisting of a benzene ring fused to an imidazole ring. The compound features a carboxaldehyde group at the 5-position, a double bond at the 2-position, and a hydrogen atom at the 1-position. This structure endows it with unique chemical properties and potential applications in various fields.

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  • 106429-59-8 Structure
  • Basic information

    1. Product Name: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI)
    2. Synonyms: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI);2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-5-carbaldehyde;2,3-Dihydro-2-oxo-1H-benzimidazole-5-carboxaldehyde;1H-BenziMidazole-5-carboxaldehyde, 2,3-dihydro-2-oxo-;2,3-Dihydro-2-oxo-1H-benzo[d]imidazol-5-carbaldehyde;2-OXO-2,3-DIHYDRO-1H-1,3-BENZODIAZOLE-5-CARBALDEHYDE;2-oxo-1,3-dihydrobenzimidazole-5-carbaldehyde
    3. CAS NO:106429-59-8
    4. Molecular Formula: C8H6N2O2
    5. Molecular Weight: 162.14544
    6. EINECS: N/A
    7. Product Categories: BENZIMIDAZOLE
    8. Mol File: 106429-59-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 194℃
    3. Flash Point: 81℃
    4. Appearance: /
    5. Density: 1.365
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
    9. PKA: 11.66±0.30(Predicted)
    10. CAS DataBase Reference: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI)(106429-59-8)
    12. EPA Substance Registry System: 1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI)(106429-59-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 106429-59-8(Hazardous Substances Data)

106429-59-8 Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of novel drugs with potential therapeutic applications.
Used in Nuclease Inhibitors:
1H-Benzimidazole-5-carboxaldehyde,2,3-dihydro-2-oxo-(9CI) is used as a precursor in the preparation of nuclease inhibitors. These inhibitors are useful in the treatment and prophylaxis of diseases where nuclease activity plays a role, such as certain types of cancer or viral infections. By inhibiting nucleases, these compounds can help regulate cellular processes and potentially prevent or slow down disease progression.

Check Digit Verification of cas no

The CAS Registry Mumber 106429-59-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,4,2 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 106429-59:
(8*1)+(7*0)+(6*6)+(5*4)+(4*2)+(3*9)+(2*5)+(1*9)=118
118 % 10 = 8
So 106429-59-8 is a valid CAS Registry Number.

106429-59-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-oxo-1,3-dihydrobenzimidazole-5-carbaldehyde

1.2 Other means of identification

Product number -
Other names 2,3-dihydro-2-oxo-1H-Benzimidazole-5-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106429-59-8 SDS

106429-59-8Downstream Products

106429-59-8Relevant articles and documents

POLYCYCLIC AMINES AS OPIOID RECEPTOR MODULATORS

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Paragraph 0129; 0269, (2018/10/11)

The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

INHIBITORS OF THE MENIN-MLL INTERACTION

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Page/Page column 93-94, (2018/01/17)

The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

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Page/Page column 134-135, (2010/11/27)

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.

ANABASEINE DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

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Page/Page column 72, (2008/06/13)

The compounds of the present invention are of formula (I): wherein A, R3, R4 is as defined herein, are useful as ligands for nicotinic receptors.

2'-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons

Rangarajan, Meera,Kim, Jung Sun,Jin, Song,Sim, Sai-Peng,Liu, Angela,Pilch, Daniel S.,Liu, Leroy F.,Lavoie, Edmond J.

, p. 1371 - 1382 (2007/10/03)

5-Phenylterbenzimidazole (1) is active as a topoisomerase I poison (topo I) and is cytotoxic to human tumor cells. No cross-resistance was observed for 1 when it was evaluated against the camptothecin-resistant cell line, CPT-K5. Derivatives of 1 substituted at the 2'-position, however, did exhibit cross-resistance to this cell line. The basis for the resistance of this cell line towards CPT is that it possesses a mutant form of topo I. These results suggest that substituents at the 2'-position may be in proximity to the wild-type enzyme. Therefore, we hypothesized that terbenzimidazoles with 2'-substituents could be capable of interacting with the enzyme and thereby influence activity within this class of topo I poisons. 5-Phenylterbenzimidazoles with a hydroxy, hydroxymethyl, mercapto, amino, N-benzoylaminomethyl, chloro, and trifluoromethyl group at the 2'-position were synthesized. In addition, several 2'-ethyl-5-phenylterbenzimidazoles were prepared containing either a methoxy, hydroxy, amino, or N-acetylamino group at the 2-position of the ethyl side-chain. These 2'-substituted 5-phenylterbenzimidazoles were evaluated as topo I poisons and for cytotoxic activity. The presence of a strong electron-withdrawing group at the 2'-position, such as a chloro or trifluoromethyl group, did enhance both topo I poisoning activity and cytotoxicity. Studies on the relative DNA binding affinity of 1 to its 2'-amino and 2'-trifluoromethyl derivatives did exhibit a correlation with their relative differences in biological activity. Copyright (C) 2000 Elsevier Science Ltd.

Heterocyclic topoisomerase poisons

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, (2008/06/13)

The invention provides a topoisomerase poison of formula I: wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof.

Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles

Rangarajan, Meera,Kim, Jung Sun,Sim, Sai-Peng,Liu, Angela,Liu, Leroy F.,LaVoie, Edmond J.

, p. 2591 - 2600 (2007/10/03)

Topoisomerase I is an enzyme that is essential for maintaining the three-dimensional structure of DNA during the processes of transcription, translation and mitosis. With the introduction of new clinical agents that are effective in poisoning topoisomeras

Novel β-lactam antibiotics

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, (2008/06/13)

Antibacterially active and animal growth-promoting novel β-lactam compounds of the formula STR1 in which R1 represents the radical STR2 Y representing N or CR9, or Y--R7 representing >C=O or >C=N--R7, Z representing O, S, or NR10, and R2 represents hydrogen or a protective group.

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