107550-30-1Relevant articles and documents
Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols
Flanagan, Mark E.,Brickner, Steven J.,Lall, Manjinder,Casavant, Jeffrey,Deschenes, Laura,Finegan, Steven M.,George, David M.,Granskog, Karl,Hardink, Joel R.,Huband, Michael D.,Hoang, Thuy,Lamb, Lucinda,Marra, Andrea,Mitton-Fry, Mark,Mueller, John P.,Mullins, Lisa M.,Noe, Mark C.,O'Donnell, John P.,Pattavina, David,Penzien, Joseph B.,Schuff, Brandon P.,Sun, Jianmin,Whipple, David A.,Young, Jennifer,Gootz, Thomas D.
, p. 385 - 390 (2011/07/09)
A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.
MONOCARBAMS
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Page/Page column 12-13, (2010/07/04)
The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, Rs, and R6 as defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of formula (I)
The total synthesis of the natural product endothelin converting enzyme (ECE) inhibitor, WS75624 B
Patt, William C.,Massa, Mark A.
, p. 1297 - 1300 (2007/10/03)
The first total synthesis of WS75624 B, 1, an endothelin converting enzyme inhibitor produced in a fermentation broth of Saccharothrix sp. No. 75624 is reported herein. WS75624 B is synthesized in 14 steps from commercially available kojic acid, 2. The synthetic methodology allows for facile substitution at multiple sites on the molecule.
2-oxo-1-[[(substituted sulfonyl)amino]carbonyl]azetidines
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, (2008/06/13)
Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and having an activating group in the 1-position of the formula STR1
1-(substituted phosphorous)-azetidinone antibacterials
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, (2008/06/13)
Antibacterial activity is exhibited by 2-azetidinones having an acylamino substituent in the 3-position and having an activating group in the 1-position of the formula STR1
3-acylamino-2-oxo-1-azetidinesulfonic acids
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, (2008/06/13)
Antibacterial activity is exhibited by 2-azetidinones activated in the 1-position with an --SO3 H group and having in the 3-position an acylamino group of the formula STR1