107575-59-7

Basic information

• Product Name: ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE
• Synonyms: ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE;2-[2-[3-(ForMylaMino)-4-Methoxyphenyl]hydrazinylidene]propanoic Acid Ethyl Ester
• CAS NO: 107575-59-7
• Molecular Formula: C₁₃H₁₇N₃O₄
• Molecular Weight: 279.29178
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 107575-59-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO
• CAS DataBase Reference: ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE(107575-59-7)
• EPA Substance Registry System: ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE(107575-59-7)

Safety Data

• Hazardous Substances Data: 107575-59-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE is used as a synthetic intermediate for the production of various organic compounds. Its unique chemical structure allows it to participate in a range of reactions, such as condensation, cyclization, and rearrangement, which are essential for the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE is used as a key building block for the development of novel drugs. Its reactivity and structural diversity make it a valuable component in the design and synthesis of new pharmaceutical agents, potentially leading to the discovery of innovative treatments for various diseases and medical conditions.
Used in Chemical Research:
ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE is also employed in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic methodologies. Its unique properties and reactivity provide researchers with valuable insights into the behavior of similar compounds and contribute to the advancement of organic chemistry.
Used in Material Science:
In the field of material science, ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE can be used as a precursor for the development of new materials with specific properties. Its incorporation into polymers, for example, may result in materials with enhanced mechanical, thermal, or electrical characteristics, depending on the desired application.

Upstream product

• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 78939-34-1 N-(5-amino-2-methoxylphenyl)formamide 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 149686-06-6 N-(2-methoxyl-5-nitrophenyl)formamide 

Downstream Products

• 119825-27-3 6-(Formylamino)-5-methoxyindol-2-carbonsaeure-ethylester 
• 80721-47-7 4,5-Dihydro-4,5-dioxo-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester 
• 72909-34-3 pyrroloquinoline quinone 
• 107575-60-0 6-amino-5-methoxy-2-ethoxycarbonylindole 
• 133706-80-6 5-Methoxy-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester 

Relevant articles and documents

Decarboxylated Methoxatin Analogues. Synthesis of 7- and 9-Decarboxymethoxatin

A total synthesis of two monodecarboxylated analogues of methoxatin (1) is described.The synthesis of 9-decarboxymethoxatin (4) was achieved starting with 8-hydroxyquinoline, constructing an appropriately substituted quinolylhydrazone of ethyl pyruvate with a Japp-Klingemann reaction and annulating the remaining pyrrole ring through a Fischer indole synthesis.The synthesis of 7-decarboxymethoxatin (3) first necessitated the construction of an appropriate indole from which the remaining pyridine ring could be annulated via a Doebner reaction.

Pyrroloquinoline quinone synthetic method

The invention discloses a synthetic method of pyrroloquinoline quinone. The synthetic method comprises the following steps: carrying out alkali treatment on 2-methoxy-5-nitroaniline hydrochloride as a raw material, so as to obtain a compound 1; carrying out formylation on the compound 1 under a catalysis condition of an ionic liquid, so as to obtain a compound 2; adopting sodium borohydride to reduce the compound 2 to obtain a compound 3; carrying out diazotization on the compound 3, and then enabling action between the diazotized compound 3 and HBF4 to obtain a compound 4; enabling reaction of the compound 4 and 2-methylethyl acetoacetate to obtain a compound 5; treating the compound 5 with formic acid to obtain a compound 6; carrying out amid catalysis and exchange with the ionic liquid on the compound 6 to obtain a compound 7; enabling reaction of the compound 7 and 2-oxodimethyl glutaconate to obtain a compound 8; feeding hydrogen chloride to the compound 8 under the action of Cu(OAc)2*2H2O to obtain a compound 9; carrying out basic hydrolysis on the compound 9 to obtain a compound 10. The synthetic method disclosed by the invention is cheap and accessible in raw materials, stable, high in reaction yield, quick in reaction, and easy for product separation, and is environment-friendly as the catalyst can be recycled.

SYNTHESIS OF PYRROLOQUINOLINE QUINONE (PQQ)

The invention relates to a novel nine step process for synthesizing PQQ (methoxatin). This process is efficient and reliably provides PQQ in excellent purity and high yield.