133706-80-6

Usage

Uses

Used in Organic Synthesis:
7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-5-METHOXY-1H-PYRROLO-[2,3-F]QUINOLINE is used as a synthetic intermediate for the development of various organic compounds. Its unique structure and functional groups make it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-5-METHOXY-1H-PYRROLO-[2,3-F]QUINOLINE is used as a key intermediate in the synthesis of novel drug candidates. Its structural diversity and the presence of multiple functional groups allow for the creation of a wide range of bioactive molecules with potential therapeutic applications.
Used in Agrochemical Industry:
7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-5-METHOXY-1H-PYRROLO-[2,3-F]QUINOLINE is also utilized in the agrochemical industry as a starting material for the development of new pesticides and other crop protection agents. Its chemical properties and reactivity enable the synthesis of compounds with improved efficacy and selectivity against target pests and diseases.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-5-METHOXY-1H-PYRROLO-[2,3-F]QUINOLINE is used as a precursor for the synthesis of various organic dyes and pigments. Its structural features and functional groups can be exploited to create a range of colored compounds with specific properties, such as lightfastness, solubility, and color intensity.
Used in Material Science:
7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-5-METHOXY-1H-PYRROLO-[2,3-F]QUINOLINE can be employed in the field of material science for the development of advanced materials with specific properties. Its chemical structure and functional groups can be used to synthesize compounds with potential applications in areas such as optoelectronics, sensors, and energy storage.

Upstream product

• 107575-59-7 ethyl pyruvate 3-formamido-4-methoxyphenyl-hydrazone 
• 78939-34-1 N-(5-amino-2-methoxylphenyl)formamide 
• 328-50-7 α-ketoglutaric acid 
• 149686-06-6 N-(2-methoxyl-5-nitrophenyl)formamide 
• 107575-60-0 6-amino-5-methoxy-2-ethoxycarbonylindole 
• 78939-37-4 4-oxo-pent-2-enedioic acid dimethyl ester 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 119825-27-3 6-(Formylamino)-5-methoxyindol-2-carbonsaeure-ethylester 
• 910885-13-1 9-hydroxy-5-methoxyl-6,7,8,9-tetrahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid 2-ethyl ester-7,9-dimethyl ester 

Downstream Products

• 80721-47-7 4,5-Dihydro-4,5-dioxo-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester 
• 72909-34-3 pyrroloquinoline quinone 

Relevant academic research and scientific papers

Pyrroloquinoline quinone synthetic method

The invention discloses a synthetic method of pyrroloquinoline quinone. The synthetic method comprises the following steps: carrying out alkali treatment on 2-methoxy-5-nitroaniline hydrochloride as a raw material, so as to obtain a compound 1; carrying out formylation on the compound 1 under a catalysis condition of an ionic liquid, so as to obtain a compound 2; adopting sodium borohydride to reduce the compound 2 to obtain a compound 3; carrying out diazotization on the compound 3, and then enabling action between the diazotized compound 3 and HBF4 to obtain a compound 4; enabling reaction of the compound 4 and 2-methylethyl acetoacetate to obtain a compound 5; treating the compound 5 with formic acid to obtain a compound 6; carrying out amid catalysis and exchange with the ionic liquid on the compound 6 to obtain a compound 7; enabling reaction of the compound 7 and 2-oxodimethyl glutaconate to obtain a compound 8; feeding hydrogen chloride to the compound 8 under the action of Cu(OAc)2*2H2O to obtain a compound 9; carrying out basic hydrolysis on the compound 9 to obtain a compound 10. The synthetic method disclosed by the invention is cheap and accessible in raw materials, stable, high in reaction yield, quick in reaction, and easy for product separation, and is environment-friendly as the catalyst can be recycled.

PYRROLOQUINOLINE QUINONE DISODIUM SALT CRYSTAL

Provided are pyrroloquinoline quinone disodium salt crystalline Forms A and B, and their preparation methods and uses. These crystalline forms have low moisture absorption and high stability, as well as excellent use and storage performances.

SYNTHESIS OF PYRROLOQUINOLINE QUINONE (PQQ)

The invention relates to a novel nine step process for synthesizing PQQ (methoxatin). This process is efficient and reliably provides PQQ in excellent purity and high yield.

Preparation of PQQ in the kg Scale

The improvement of the PQQ synthesis according to the method of Corey and Tramontano allows the preparation of the triester of this cofactor in the kg scale with an overall yield of 13percent (average 78percent per step), without a bottleneck in the sequence and with crystalline, analytically pure intermediates.The new purification of free PQQ from conc.H2SO4 is remarkable with respect to the application as well as to the stability of this natural product.