149686-06-6

Basic information

• Product Name: 2-METHOXY-5-NITROFORMANILIDE
• Synonyms: 2-METHOXY-5-NITROFORMANILIDE;N-(2-Methoxy-5-nitrophenyl)forMaMide;NSC 99632
• CAS NO: 149686-06-6
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16012
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 149686-06-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Solubility: DMSO, Ethanol, Ethyl Acetate, Methanol
• CAS DataBase Reference: 2-METHOXY-5-NITROFORMANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-5-NITROFORMANILIDE(149686-06-6)
• EPA Substance Registry System: 2-METHOXY-5-NITROFORMANILIDE(149686-06-6)

Safety Data

• Hazardous Substances Data: 149686-06-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

2-Methoxy-5-nitroformanilide (cas# 149686-06-6) is a compound useful in organic synthesis.

Upstream product

• 64-18-6 formic acid 
• 99-59-2 3-amino-4-methoxynitrobenzene 

Downstream Products

• 133706-80-6 5-Methoxy-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester 
• 107575-60-0 6-amino-5-methoxy-2-ethoxycarbonylindole 
• 119825-27-3 6-(Formylamino)-5-methoxyindol-2-carbonsaeure-ethylester 
• 107575-59-7 ethyl pyruvate 3-formamido-4-methoxyphenyl-hydrazone 
• 72909-34-3 pyrroloquinoline quinone 
• 80721-47-7 4,5-Dihydro-4,5-dioxo-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester 
• 19871-39-7 N-methyl-2-methoxy-5-nitroaniline 
• 119825-21-7 3-Formylamino-4-methoxy-benzenediazonium; chloride 
• 78939-34-1 N-(5-amino-2-methoxylphenyl)formamide 
• 15999-35-6 5-Nitro-2-methoxy-phenyl-isocyaniddichlorid 

Relevant articles and documents

Pyrroloquinoline quinone synthetic method

The invention discloses a synthetic method of pyrroloquinoline quinone. The synthetic method comprises the following steps: carrying out alkali treatment on 2-methoxy-5-nitroaniline hydrochloride as a raw material, so as to obtain a compound 1; carrying out formylation on the compound 1 under a catalysis condition of an ionic liquid, so as to obtain a compound 2; adopting sodium borohydride to reduce the compound 2 to obtain a compound 3; carrying out diazotization on the compound 3, and then enabling action between the diazotized compound 3 and HBF4 to obtain a compound 4; enabling reaction of the compound 4 and 2-methylethyl acetoacetate to obtain a compound 5; treating the compound 5 with formic acid to obtain a compound 6; carrying out amid catalysis and exchange with the ionic liquid on the compound 6 to obtain a compound 7; enabling reaction of the compound 7 and 2-oxodimethyl glutaconate to obtain a compound 8; feeding hydrogen chloride to the compound 8 under the action of Cu(OAc)2*2H2O to obtain a compound 9; carrying out basic hydrolysis on the compound 9 to obtain a compound 10. The synthetic method disclosed by the invention is cheap and accessible in raw materials, stable, high in reaction yield, quick in reaction, and easy for product separation, and is environment-friendly as the catalyst can be recycled.

An eco-benign and highly efficient procedure for N-acylation catalyzed by heteropolyanion-based ionic liquids using carboxylic acid under solvent-free conditions

An eco-benign and highly efficient route for N-acylation of amines has been developed by treating amines with corresponding carboxylic acids in the presence of 2 mol % of heteropolyanion-based ionic liquids as catalysts under solvent-free conditions. This practical reaction could tolerate a wide range of substrates. Thus, various N-acylation products including N-acyl α-amino acid derivatives were obtained in moderate to excellent yields at 70 C to 120 C. Moreover, recycling studies revealed that heteropolyanion-based ionic liquids were easily reusable for this N-acylation. This method provides a green and much improved protocol over the existing methods.

Preparation of PQQ in the kg Scale

The improvement of the PQQ synthesis according to the method of Corey and Tramontano allows the preparation of the triester of this cofactor in the kg scale with an overall yield of 13percent (average 78percent per step), without a bottleneck in the sequence and with crystalline, analytically pure intermediates.The new purification of free PQQ from conc.H2SO4 is remarkable with respect to the application as well as to the stability of this natural product.