107667-60-7

Basic information

• Product Name: Polaprezinc
• Synonyms: POLAPREZINC;zinc l-carnosine complex;zinc n-(3-aminopropionyl)histidine;ZINC CARNOSINE;[b-Alanyl-kN-L-histidinato(2-)-kN,kO]-zinc;b-Alanyl-L-histidinato Zinc;Promac;Z 103
• CAS NO: 107667-60-7
• Molecular Formula: C₉H₁₂N₄O₃*Zn
• Molecular Weight: 289.61
• EINECS: 1592732-453-0
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 107667-60-7.mol

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 177.5°C
• Flash Point: 291oC
• Appearance: White to pale-yellow crystalline solid
• Storage Temp.: Refrigerator
• Solubility: Aqueous Acid (Slightly)
• CAS DataBase Reference: Polaprezinc(CAS DataBase Reference)
• NIST Chemistry Reference: Polaprezinc(107667-60-7)
• EPA Substance Registry System: Polaprezinc(107667-60-7)

Safety Data

• Hazardous Substances Data: 107667-60-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Polaprezinc is used as an anti-gastric ulcer agent for promoting the healing of gastric ulcers and preventing ulcer relapse.
Used in Dietary Supplements Industry:
Polaprezinc is used as a new dietary supplement for its anti-ulcer and antioxidative properties. It is available under the brand name PepZinGI(R) and is approved by the federal agency.
Used in Orthopedics:
Polaprezinc is used as a potential treatment for osteoporosis due to its ability to activate bone formation and inhibit bone resorption, thus preventing the deterioration of bone metabolism.
Used in Hepatology:
Polaprezinc is used for the prophylaxis and treatment of alcoholic hepatopathy, viral hepatitis, or other hepatopathies caused by certain drugs, poisons, and radiation.

Originator

Hamari Chemicals (Japan)

InChI:InChI=1/C9H14N4O3.Zn/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6;/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16);/q;+2

Upstream product

• 5970-45-6 zinc(II) acetate dihydrate 
• 305-84-0 carnosine 
• 1535206-09-7 Zn(β-alanyl-L-histidine)*DMF 

Relevant articles and documents

Methods for producing L-carnosine zinc complex

Disclosed is a method for conveniently synthesizing, at high purity and high yield, a crystalline L-carnosine zinc complex which is useful as an antiulcer treatment agent without having a separate refining step. A method for producing an L-carnosine zinc complex comprises the steps of: suspending L-carnosine and zinc salts in an alcohol or a water-containing alcohol; producing an alkali metal compound solution by dissolving an alkali metal compound in an alcohol or a water-containing alcohol; precipitating an L-carnosine zinc complex by adding the alkali metal compound solution in a suspension of the L-carnosine and the zinc salts; adding refined water in a reactive liquid including the L-carnosine zinc complex; and filtering an L-carnosine zinc complex crystal.COPYRIGHT KIPO 2017

Guest-adaptable and water-stable peptide-based porous materials by imidazolate side chain control

The peptide-based porous 3D framework, ZnCar, has been synthesized from Zn2+ and the natural dipeptide carnosine (β-alanyl-L-histidine). Unlike previous extended peptide networks, the imidazole side chain of the histidine residue is deprotonated to afford Zn-imidazolate chains, with bonding similar to the zeolitic imidazolate framework (ZIF) family of porous materials. ZnCar exhibits permanent microporosity with a surface area of 448 m2 g-1, and its pores are 1D channels with 5 A openings and a characteristic chiral shape. This compound is chemically stable in organic solvents and water. Single-crystal X-ray diffraction (XRD) showed that the ZnCar framework adapts to MeOH and H2O guests because of the torsional flexibility of the main His-β-Ala chain, while retaining the rigidity conferred by the Zn-imidazolate chains. The conformation adopted by carnosine is driven by the H bonds formed both to other dipeptides and to the guests, permitting the observed structural transformations. A peptide-based porous framework (ZnCar×DMF), which is formed by the assembly of Zn with carnosine, exhibits permanent microporosity and has pores of chiral shape. Zn-imidazolate bonding to the histidine side chain affords the chemical stability of the framework in water, and the His-β-Ala main chain provides flexibility while conferring structural adaptability on the framework in the presence of different guest molecules.