- Methods for producing L-carnosine zinc complex
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Disclosed is a method for conveniently synthesizing, at high purity and high yield, a crystalline L-carnosine zinc complex which is useful as an antiulcer treatment agent without having a separate refining step. A method for producing an L-carnosine zinc complex comprises the steps of: suspending L-carnosine and zinc salts in an alcohol or a water-containing alcohol; producing an alkali metal compound solution by dissolving an alkali metal compound in an alcohol or a water-containing alcohol; precipitating an L-carnosine zinc complex by adding the alkali metal compound solution in a suspension of the L-carnosine and the zinc salts; adding refined water in a reactive liquid including the L-carnosine zinc complex; and filtering an L-carnosine zinc complex crystal.COPYRIGHT KIPO 2017
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Paragraph 0021; 0022
(2017/06/20)
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- Guest-adaptable and water-stable peptide-based porous materials by imidazolate side chain control
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The peptide-based porous 3D framework, ZnCar, has been synthesized from Zn2+ and the natural dipeptide carnosine (β-alanyl-L-histidine). Unlike previous extended peptide networks, the imidazole side chain of the histidine residue is deprotonated to afford Zn-imidazolate chains, with bonding similar to the zeolitic imidazolate framework (ZIF) family of porous materials. ZnCar exhibits permanent microporosity with a surface area of 448 m2 g-1, and its pores are 1D channels with 5 A openings and a characteristic chiral shape. This compound is chemically stable in organic solvents and water. Single-crystal X-ray diffraction (XRD) showed that the ZnCar framework adapts to MeOH and H2O guests because of the torsional flexibility of the main His-β-Ala chain, while retaining the rigidity conferred by the Zn-imidazolate chains. The conformation adopted by carnosine is driven by the H bonds formed both to other dipeptides and to the guests, permitting the observed structural transformations. A peptide-based porous framework (ZnCar×DMF), which is formed by the assembly of Zn with carnosine, exhibits permanent microporosity and has pores of chiral shape. Zn-imidazolate bonding to the histidine side chain affords the chemical stability of the framework in water, and the His-β-Ala main chain provides flexibility while conferring structural adaptability on the framework in the presence of different guest molecules.
- Katsoulidis, Alexandros P.,Park, Kyo Sung,Antypov, Dmytro,Marti-Gastaldo, Carlos,Miller, Gary J.,Warren, John E.,Robertson, Craig M.,Blanc, Frederic,Darling, George R.,Berry, Neil G.,Purton, John A.,Adams, Dave J.,Rosseinsky, Matthew J.
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supporting information
p. 193 - 198
(2014/01/17)
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