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107667-60-7

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Basic Information
CAS No.: 107667-60-7
Name: Polaprezinc
Article Data: 2
Molecular Structure:
Molecular Structure of 107667-60-7 (Polaprezinc)
Formula: C9H12N4O3Zn
Molecular Weight: 289.609
Synonyms: Zinc,[N-b-alanyl-L-histidinato(2-)-N,NN,Oa]-;L-Histidine, N-b-alanyl-, zinc complex;Promac;Promac (antiulcer agent);Z 103;Zinc L-carnosine;b-Alanyl-L-histidinato zinc;
EINECS: 600-848-7
Melting Point: 300 ºC
Boiling Point: 557.6oC at 760 mmHg
Flash Point: 291oC
Appearance: White to pale-yellow crystalline solid
PSA: 101.31000
LogP: -0.39430
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Chemistry

IUPAC Name: Zinc(2R)-2-[(3-amino-1-oxidopropylidene)amino]-3-(1H-imidazol-5-yl)propanoate
The MF of Polaprezinc (CAS NO.107667-60-7) is C9H12N4O3Zn.

                         
The MW of Polaprezinc (CAS NO.107667-60-7) is 289.62558.
Synonyms of Polaprezinc (CAS NO.107667-60-7): Histidine, beta-alanyl-, zinc salt ; zinc 2-(beta-Alanylamino)-3-(imidazol-3-id-4-yl)propanoate ; Zinc carnosine
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
Apperance: White To Pale-Yellow Crystalline Solid
Melting Point: >300 °C

Uses

  Polaprezinc (CAS NO.107667-60-7) is used as A novel anti-gastric ulcer agent and a new dietary supplement approved by the federal agency.

Toxicity Data With Reference

1.    

orl-rat LD50:7375 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 41 (1991),1033.
2.    

ipr-rat LD50:405 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 41 (1991),1033.
3.    

scu-rat LD50:>5 g/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 41 (1991),1033.
4.    

orl-mus LD50:1269 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 41 (1991),1033.
5.    

ipr-mus LD50:165 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 41 (1991),1033.
6.    

scu-mus LD50:758 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 41 (1991),1033.
7.    

orl-dog LD:>200 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 45 (1995),52.
8.    

orl-mky LD:>626 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 43 (1993),562.

Safety Profile

A poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and Zn.