108838-36-4

Basic information

• Product Name: Benzofuran, 4,6-dimethoxy-3-phenyl-
• CAS NO: 108838-36-4
• Molecular Formula: C16H14O3
• Molecular Weight: 254.285
• Mol File: 108838-36-4.mol

Chemical Properties

• CAS DataBase Reference: Benzofuran, 4,6-dimethoxy-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 4,6-dimethoxy-3-phenyl-(108838-36-4)
• EPA Substance Registry System: Benzofuran, 4,6-dimethoxy-3-phenyl-(108838-36-4)

Safety Data

• Hazardous Substances Data: 108838-36-4(Hazardous Substances Data)

Upstream product

• 105243-57-0 2-(3,5-dimethoxyphenoxy)-1-phenylethan-1-one 
• 7758-73-8 5,7-dihydroxy-4-phenyl-2H-1-benzopyran-2-one 
• 26952-92-1 5,7-dimethoxy-4-phenyl-chromen-2-one 
• 500-99-2 3,5-dimethoxyphenol 
• 61711-82-8 (3,5-dimethoxyphenoxy)ethanenitrile 
• 98-80-6 phenylboronic acid 
• 110423-69-3 4,6-dimethoxy-3-phenyl-benzofuran-2-carboxylic acid 

Downstream Products

• 476352-01-9 4,6-dimethoxy-3-phenylbenzofuran-2-carbaldehyde 
• 229977-87-1 1-[2-(4,6-dimethoxy-3-phenyl-benzofuran-2-yl)-indol-1-yl]-ethanone 
• 476352-15-5 N-t-butyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide 
• 476352-14-4 α-(4-chlorophenyl)-4,6-dimethoxy-3-phenylbenzofuran-2-methanol 
• 476352-18-8 (4,6-dimethoxy-3-phenyl-benzofuran-2-yl)-p-tolyl-methanol 
• 476352-08-6 N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)glyoxylamide 
• 476352-17-7 N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide 
• 476352-25-7 (4,6-dimethoxy-3-phenyl-benzofuran-2-yl)-hydroxy-acetic acid methyl ester 
• 476352-16-6 2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide 
• 476352-07-5 2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)glyoxylamide 
• 476352-27-9 1-(4,6-dimethoxy-3-phenyl-benzofuran-2-yl)-ethanol 
• 476352-11-1 2-hydroxymethyl-4,6-dimethoxy-3-phenylbenzofuran 
• 476352-12-2 7-hydroxymethyl-4,6-dimethoxy-3-phenylbenzofuran 

Relevant articles and documents

Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)participates in diverse cancer-associated signaling pathways, playing an oncogenic role in multiple human cancers, including hepatocellular carcinoma (HCC). Our recent works clarify that Pin1 modulates miRNAs biogenesis by interacting with ERK-phosphorylated exportin-5 (XPO5)and changing XPO5 conformation, giving a potential target for HCC treatment. Herein, we discover 4,6-bis(benzyloxy)-3-phenylbenzofuran (TAB29)as a novel Pin1 inhibitor that targets Pin1 PPIase domain. TAB29 potently inhibits Pin1 activity with the IC50 value of 874 nM and displays an excellent selectivity toward Pin1 in vitro. Cell-based biological evaluation reveals that TAB29 significantly suppresses cell proliferation of HCC cells through restoring the nucleus-to-cytoplasm export of XPO5 and upregulating mature miRNAs expression. Collectively, this work provides a promising small molecule lead compound for Pin1 inhibition, highlighting the therapeutic potential of miRNA-based treatment for human cancers.

Cationic palladium(II)-catalyzed addition of arylboronic acids to nitriles. One-step synthesis of benzofurans from phenoxyacetonitriles

(Chemical Equation Presented) A cationic palladium complex catalyzed addition of arylboronic acids to nitrites to yield aryl ketones with moderate to good yields was developed. A one-step synthesis of benzofurans from phenoxyacetonitriles under the catalysis of [(bpy)Pd+(μ-OH)] 2(-OTf)2 or [(bpy)Pd2+(H 2O2)2](-OTf)2 was developed which showed that the cationic palladium catalyst is highly active for these addition reactions.

Preparation of activated benzofurans and their reactions with aldehydes

Reactions of 3-substituted 4,6-dimethoxybenzofurans with formaldehyde and aryl aldeydes in the presence of acetic acid and phosphoryl chloride respectively give new macrocyclic calix[3]benzofurans, predominantly with an unsymmetrical linkage pattern. Inco