7758-73-8

Usage

Uses

Used in Pharmaceutical Industry:
5,7-Dihydroxy-4-phenylcoumarin is used as a pharmaceutical agent for its antioxidant and anti-inflammatory properties, which can contribute to the treatment of various inflammatory and oxidative stress-related conditions.
Used in Cardiovascular Disease Treatment:
In the field of cardiology, 5,7-Dihydroxy-4-phenylcoumarin is used as a potential treatment for cardiovascular diseases due to its cardioprotective effects, which may help in reducing the risk of heart-related complications.
Used in Cancer Therapy:
5,7-Dihydroxy-4-phenylcoumarin is used as a potential anticancer agent, as research has indicated its ability to induce apoptosis in cancer cells, making it a candidate for further investigation in oncology.
Used in Cosmetics Industry:
In the cosmetics industry, 5,7-Dihydroxy-4-phenylcoumarin is used as a natural sunscreen agent, with studies suggesting its ability to protect the skin from harmful UV radiation, thus offering a safer alternative to synthetic sunscreens.
Overall, 5,7-Dihydroxy-4-phenylcoumarin's multifaceted potential makes it a valuable compound for various applications across different industries, with ongoing research aimed at further exploring and optimizing its benefits.

InChI:InChI=1/C15H10O4/c16-10-6-12(17)15-11(9-4-2-1-3-5-9)8-14(18)19-13(15)7-10/h1-8,16-17H

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 1823-99-0 3-amino-3-phenylacrylonitrile 
• 26952-92-1 5,7-dimethoxy-4-phenyl-chromen-2-one 
• 855903-07-0 5-acetoxy-7-methoxy-4-phenyl-coumarin 
• 24258-38-6 2-oxo-4-phenyl-2H-chromene-5,7-diyl diacetate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 3555-86-0 2-benzoylphloroglucinol 
• 127-09-3 sodium acetate 
• 2732-18-5 5,7-dihydroxy-2H-chromen-2-one 
• 587-85-9 diphenylmercury(II) 
• 637-44-5 phenylpropyolic acid 
• 141-97-9 ethyl acetoacetate 
• 98-86-2 acetophenone 

Downstream Products

• 36910-59-5 7-hydroxy-5-methoxy-4-phenylcoumarin 
• 57877-99-3 5-hydroxy-7-methoxy-4-phenylcoumarin 
• 26952-92-1 5,7-dimethoxy-4-phenyl-chromen-2-one 
• 213834-75-4 8-benzoyl-5,7-dihydroxy-4-phenyl-2H-chromen-2-one 
• 213834-81-2 6-benzoyl-5,7-dihydroxy-4-phenyl-2H-chromen-2-one 
• 24258-38-6 2-oxo-4-phenyl-2H-chromene-5,7-diyl diacetate 
• 680575-76-2 7-hydroxy-5-methoxy-4-phenyl-8-tigloylcoumarin 
• 685844-46-6 5,7-dimethoxy-4-phenyl-8-tigloylcoumarin 
• 108838-36-4 4,6-dimethoxy-3-phenylbenzofuran 
• 108238-45-5 5,6,7-trihydroxy-4-phenyl-coumarin 
• 110423-69-3 4,6-dimethoxy-3-phenyl-benzofuran-2-carboxylic acid 
• 108971-85-3 6-hydroxy-5,7-dimethoxy-4-phenyl-coumarin 
• 109555-09-1 6-acetoxy-5,7-dimethoxy-4-phenyl-coumarin 
• 110144-69-9 5,6,7-triacetoxy-4-phenyl-coumarin 

Relevant academic research and scientific papers

TWO NEW NEOFLAVONOIDS AND C-GLYCOSYLFLAVONES FROM PASSIFLORA SERRATODIGITATA

The aerial parts of Passiflora serratodigitata yielded 5,7-dihydroxy-4-phenylcoumarin, its 7-β-glucoside and the known C-glycosylflavones 2"-xylosylvitexin, 2"-xylosylisovitexin, vitexin, isovitexin, avicenin, and orientin.The known flavone chrysin was also isolated.This is the first report of neoflavonoids in the family Passifloraceae.Key Word Index - Passiflora serratodigitata; Passifloraceae; 5,7-dihydroxy-4-phenylcoumarin (serratin); serratin 7-β-glucoside; C-glycosylflavones.

Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: Protein transacetylase

Our earlier observations led to the identification of a microsomal enzyme termed as acetoxy drug: protein transacetylase (TAase) catalyzing the transfer of acetyl groups from acetylated polyphenols to the receptor proteins. TAase was conveniently assayed

Synthesis of novel coumarin containing conjugated fluorescent polymers by Suzuki cross-coupling reactions and their chemosensing studies for iron and mercury ions

Conjugated fluorescent polymers are very useful materials for chemical and biochemical sensors. Herein we report the synthesis of four novel conjugated coumarin-containing fluorescent co-polymers (P1–P4) by palladium catalyzed Suzuki-Miyaura cross-couplin

Synthesis of C4-substituted coumarins via Pechmann condensation catalyzed by sulfamic acid. Insights into the reaction mechanism by HRMS analysis

A series of functionalized C4-substituted coumarins were synthesized by exploring the reaction of activated and non-activated phenols and β-ketoesters under solvent-free conditions in the presence of sulfamic acid as a Br?nsted acid catalyst. Fifteen exam

Compounds for preventing or treating lipid metabolism-related diseases

The present invention relates to the field of biomedicines, and in particular to a structure capable of binding LC3 and a structure capable of binding a lipid droplet linked together by a covalent linkage, thereby forming a 'LC3 binding moiety - lipid dro

MnSb2O6-chitosan nanocomposite: An efficient catalyst for the synthesis of coumarins via Pechmann reaction

In this work, MnSb2O6-chitosan nanocomposites were synthesized and have been employed in Pechmann condensation for the synthesis of coumarin derivatives. MnSb2O6-chitosan nanocomposites were characterized by Fou

Investigation of HMG-CoA reductase inhibitory and antioxidant effects of various hydroxycoumarin derivatives

Cardiovascular diseases are one of the primary causes of deaths worldwide, and the development of atherosclerosis is closely related to hypercholesterolemia. As the reduction of the low-density lipoprotein cholesterol level is critical for treating these

Nanosilica molybdic acid: synthesis, characterization and application as a green and reusable catalyst for the Pechmann condensation

Abstract: Nanosilica molybdic acid (SMA NPs) was founded as an efficient and recyclable nanocatalyst for the synthesis of coumarin derivatives in excellent yields with good purity. Nano-SMA as a new solid acid was characterized by X-ray fluorescence, X-ray diffraction, energy-dispersive X-ray analyzer, transmission electron microscopy and Fourier transform infrared spectroscopy. Coumarin derivatives were obtained via the Pechmann condensation reaction of phenols and β-ketoesters at 80?°C under solvent-free conditions. The main advantages of the present procedure are high yields, shorter reaction time and green chemistry procedure, simple work-up and inexpensive and reusability of the catalyst. Graphical Abstract: [Figure not available: see fulltext.]

Preparation of a novel, efficient, and recyclable magnetic catalyst, γ-Fe2O3@HAp-Ag nanoparticles, and a solvent- and halogen-free protocol for the synthesis of coumarin derivatives

In this protocol, Ag supported on the hydroxyapatite-core–shell magnetic γ-Fe2O3nanoparticles (γ-Fe2O3@HAp-Ag NPs) as a novel, efficient, and magnetically recyclable catalyst is synthesized, and characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM). The use of the catalyst is described in the synthesis of coumarin derivatives by the Pechmann condensation of various phenols with β-ketoesters under solvent- and halogen-free conditions at 80?°C. This novel and inexpensive method offers advantages, such as recyclability simple experimental protocol, short reaction time, minimal work-up procedure, and excellent yields of products, together with desirable, eco-friendly, green aspects by avoiding toxic elements and solvents, and ease of recovery from the reaction mixture using an external magnet.

SnCl4 grafted on silica gel: an efficient catalyst for solvent-free synthesis of coumarins via the Pechmann condensation

A facile synthesis of substituted coumarins via Pechmann condensation catalyzed by SnCl4 grafted on silica gel is described, which was conducted under solvent-free condition in high yields. The catalyst is noncorrosive and can be easily prepared and separated from the reaction mixture. This methodology offers some advantages with regard to yield of products, simplicity in operation and green aspects.