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3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester, also known as DMDO-Pentanedioic acid monomethyl ester, is a chemical compound characterized by its molecular formula C10H20O6Si. It is a monomethyl ester derivative of pentanedioic acid, featuring a silyl functional group. 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is a clear, colorless liquid with a molecular weight of 260.35 g/mol and is recognized for its stability under normal conditions. It is often utilized as a reagent in organic synthesis and serves as a building block for the synthesis of other organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals.

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  • Pentanedioic acid,3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-methyl ester

    Cas No: 109462-20-6

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  • 109462-20-6 Structure
  • Basic information

    1. Product Name: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester
    2. Synonyms: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester;3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]Pentanedioic acid 1-methyl ester;3-((t-butyldimethylsilyl)oxy)-5-methoxy-5-oxopentanoic acid;3-(tert-Butyl(dimethyl)silyl)oxy-5-methoxy-5-oxo-pentanoic acid
    3. CAS NO:109462-20-6
    4. Molecular Formula: C12H24O5Si
    5. Molecular Weight: 248.3483
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 109462-20-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester(109462-20-6)
    11. EPA Substance Registry System: 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester(109462-20-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 109462-20-6(Hazardous Substances Data)

109462-20-6 Usage

Uses

Used in Organic Synthesis:
3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the formation of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is used as an intermediate in the production of pharmaceuticals, playing a crucial role in the synthesis of active pharmaceutical ingredients.
Used in Agrochemical Synthesis:
3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is also utilized in the agrochemical industry, where it serves as a building block for the synthesis of various agrochemicals, such as pesticides and herbicides.
Used in Specialty Chemicals:
3-[[(1,1-Dimethyl)dimethylsily]oxy]pentanedioic acid monomethyl ester is used in the production of specialty chemicals, where its unique properties and reactivity contribute to the development of high-value chemical products for specific applications.

Check Digit Verification of cas no

The CAS Registry Mumber 109462-20-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,4,6 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 109462-20:
(8*1)+(7*0)+(6*9)+(5*4)+(4*6)+(3*2)+(2*2)+(1*0)=116
116 % 10 = 6
So 109462-20-6 is a valid CAS Registry Number.

109462-20-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[[(1,1-DIMETHYL)DIMETHYLSILY]OXY]PENTANEDIOIC ACID MONOMETHYL ESTER

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:109462-20-6 SDS

109462-20-6Relevant articles and documents

A process for preparing rosuvastatin calcium intermediate method

-

Paragraph 0039-0040; 0045-0046, (2017/08/15)

The invention relates to a method for preparing a rosuvastatin calcium intermediate, in particular to a preparation method for a compound shown in the formula 3. According to the method, ethyl (R)-(-)-4-cyano-3-hydroxybutyate is mainly used as an initial material for performing a hydroxyl protecting reaction and then the esterification reaction is performed, so that the target product is prepared. The preparation method provided by the invention is simple in operation, less in reaction steps and greatly reduces production cost; moreover, the rosuvastatin calcium intermediate is high in purity and yield, and stable in quality and has a wide prospect in the industrial application.(shown in the specification).

DOSY NMR for monitoring self aggregation of bifunctional organocatalysts: Increasing enantioselectivity with decreasing catalyst concentration

Jang, Hyeong Bin,Rho, Ho Sik,Oh, Joong Suk,Nam, Eun Hye,Park, Sang Eun,Bae, Han Yong,Song, Choong Eui

scheme or table, p. 3918 - 3922 (2010/09/17)

In this report, we demonstrate that self-aggregation is an intrinsic problem of bifunctional organocatalysts, especially in the case when the substrates do not have functional groups which are able to bind strongly with catalyst. Due to their self-associa

PROCESS AND INTERMEDIATES FOR THE SELECTIVE SYNTHESIS OF FLUVASTATIN

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Page/Page column 7, (2010/10/20)

The invention relates to process for the selective preparation of 3-hydroxy-6-dialkoxyphosphoryl-5-oxo-hexanoic acid esters, comprising a first step, in which a methylphosphonic acid dialkylester is treated with a base, and a second step, in which the pro

Optical resolution of 3-(silyloxy)glutaric acid half esters and their utilization for enantioconvergent synthesis of a HMG-CoA reductase inhibitor

Konoike, Toshiro,Okada, Tetsuo,Araki, Yoshitaka

, p. 3037 - 3040 (2007/10/03)

Useful chiral synthons, (3R)- and (3S)-[(tert- butyldimethylsilyl)oxy]pentanedioic acid monomethyl ester, (R)-1 and (S)-1, were obtained by optical resolution of a racemic mixture of 1. Sulfoxide 8 has been developed from (S)-1 as a new building block for preparing HMG-CoA reductase inhibitors. Two alternate chiral synthons 2 and 8, synthesized from (R)-1 and (S)-1, respectively, were employed for enantioconvergent synthesis of potent inhibitor 15 containing a pyrrole moiety.

3-Hydroxyglutarate and β,γ-Epoxy Esters as Substrates for Pig Liver Esterase (PLE) and α-Chymotrypsin

Mohr, Peter,Roesslein, Lukas,Tamm, Christoph

, p. 142 - 152 (2007/10/02)

The pH dependence of the α-chymotrypsin-catalyzed hydrolysis of dimethyl 3-hydroxyglutarate (3) has been studied.The e.e. was determined by HPLC analysis of diastereoisomeric camphanoic-acid derivatives.Kinetic resolution of the β,γ-epoxy esters 10 and 24 by pig liver esterase has been shown to provide an alternative access to chiral β-hydroxy esters and acids of high optical purity.By this latter method, the unnatural enantiomer of γ-amino-β-hydroxybutyric acid (GABOB) has been sinthesized.Finally, dimethyl meso-3,4-epoxyadipate (19) was hydrolyzed by pig liver esterase with almost 100 percent selectivity.

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