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1095010-47-1

1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester, also known as 1-tert-Butyl 3-Methyl 5-Hydroxypiperidine-1,3-dicarboxylate, is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes a piperidine ring, hydroxyl, and ester functional groups.
Used in Pharmaceutical Industry:
1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester is used as an intermediate in the synthesis of heterocyclylaminopyrazine derivatives for use as CHK-1 inhibitors. These inhibitors play a crucial role in the regulation of cell cycle progression and have potential applications in the treatment of cancer.
1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester is also used to prepare pyrrolidinylimidazopyridinylpiperidinylmethanone derivatives and analogs for use as diacylglycerol acyltransferase 2 (DGAT2) inhibitors. DGAT2 inhibitors can help in the management of lipid metabolism and may have potential applications in the treatment of metabolic disorders such as obesity and diabetes.

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  • 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester

    Cas No: 1095010-47-1

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  • 1095010-47-1 Structure

  • Basic information

    1. Product Name: 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester
    2. Synonyms: 1-tert-Butyl 3-methyl 5-hydroxypiperidine-1,3-dicarboxylate;O1-tert-Butyl O3-methyl 5-hydroxypiperidine-1,3-dicarboxylate;Methyl 1-Boc-5-hydroxypiperidine-3-carboxylate;
    3. CAS NO:1095010-47-1
    4. Molecular Formula: C12H21NO5
    5. Molecular Weight: 259.3
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1095010-47-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 352.1 °C at 760 mmHg
    3. Flash Point: 166.8 °C
    4. Appearance: /
    5. Density: 1.182 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 14.33±0.40(Predicted)
    10. CAS DataBase Reference: 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester(1095010-47-1)
    12. EPA Substance Registry System: 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester(1095010-47-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1095010-47-1(Hazardous Substances Data)

1095010-47-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1095010-47-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,5,0,1 and 0 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1095010-47:
(9*1)+(8*0)+(7*9)+(6*5)+(5*0)+(4*1)+(3*0)+(2*4)+(1*7)=121
121 % 10 = 1
So 1095010-47-1 is a valid CAS Registry Number.

1095010-47-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 1-Boc-5-Hydroxypiperidine-3-carboxylate

1.2 Other means of identification

Product number -
Other names Methyl 1-Boc-5-hydroxypiperidine-3-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1095010-47-1 SDS

1095010-47-1Relevant articles and documents

INHIBITORS OF MYOCARDIN-RELATED TRANSCRIPTION FACTOR AND SERUM RESPONSE FACTOR (MRTF/SRF)-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME

-

Paragraph 00209, (2016/06/01)

Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor ("MRTF/SRF"), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

SERINE/THREONINE KINASE INHIBITORS

-

, (2015/07/16)

Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

SUBSTITUTED [1,2,4] TRIAZOLO [1,5-A] PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS

-

, (2015/11/10)

The invention provides a chemical entity of Formula (I): wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of

1,5-Substituted nipecotic amides: Selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability

DeNinno, Michael P.,Wright, Stephen W.,Visser, Michael S.,Etienne, John B.,Moore, Dianna E.,Olson, Thanh V.,Rocke, Benjamin N.,Andrews, Melissa P.,Zarbo, Cynthia,Millham, Michele L.,Boscoe, Brian P.,Boyer, David D.,Doran, Shawn D.,Houseknecht, Karen L.

, p. 3095 - 3098 (2011/06/24)

The first highly potent and selective PDE8 inhibitors are disclosed. The initial tetrahydroisoquinoline hit was transformed into a nipecotic amide series in order to address a reactive metabolite issue. Reduction of lipophilicity to address metabolic liab

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