109613-93-6Relevant articles and documents
A concise approach towards the synthesis of WS75624 a and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles
Dash, Jyotirmayee,Melillo, Bruno,Arseniyadis, Stellios,Cossy, Janine
, p. 2246 - 2249 (2011/05/05)
Synthetic approach towards precursors of WS75624 A and WS75624 B, two potent endothelin converting enzyme (ECE) inhibitors and potential antihypertensive agents, is reported featuring a key cross-metathesis between a vinyl-functionalized thiazole and a terminal olefin. As the two natural products only differ by the nature of their hydroxyalkyl side-chain, our convergent strategy enable the synthesis of key intermediates of both molecules in a limited amount of steps.
First synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine
Catalani, Maria Pia,Paio, Alfredo,Perugini, Lorenzo
scheme or table, p. 6783 - 6785 (2011/02/24)
The 2,2-difluorobenzodioxole moiety has been introduced in medicinal chemistry research as a potential metabolically more stable derivative of the benzodioxole fragment. Herein we present, to the best of our knowledge, the first synthesis of 4-chloro-2,2-
New Synthesis of Orelline by Metalation of Methoxypyridines
Trecourt, Francois,Mallet, Marc,Mongin, Olivier,Gervais, Bruno,Queguiner, Guy
, p. 8373 - 8380 (2007/10/02)
A new total synthesis in five steps of alkaloid Orelline is reported.The methodology involves metalation of methoxypyridines to afford 2-halo-3,4-dimethoxypyridine on which an homocoupling reaction is performed to build the 2,2'-bipyridyl structure of the
Syntheses of Hydroxylated Bipyridines, I. - Orellanine, the Poison of a Toadstool
Dehmlow, Eckehard V.,Schulz, Hans-Joachim
, p. 857 - 862 (2007/10/02)
Two syntheses of orellanine, -3,3',4,4'-tetrol-1,1'-dioxide (5b), are developed which comprise 10 or 11 steps, respectively.The chemical reactions of 5b with diazomethane and on UV irradiation are described.