109613-93-6

Basic information

• Product Name: Pyridine,3,4-dimethoxy-(9CI)
• Synonyms: Pyridine,3,4-dimethoxy-(9CI)
• CAS NO: 109613-93-6
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.15186
• Product Categories: PYRIDINE
• Mol File: 109613-93-6.mol

Chemical Properties

• Boiling Point: 202.6°C at 760 mmHg
• Flash Point: 72.9°C
• Appearance: /
• Density: 1.064g/cm³
• Vapor Pressure: 0.413mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Pyridine,3,4-dimethoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine,3,4-dimethoxy-(9CI)(109613-93-6)
• EPA Substance Registry System: Pyridine,3,4-dimethoxy-(9CI)(109613-93-6)

Safety Data

• Hazardous Substances Data: 109613-93-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pyridine,3,4-dimethoxy-(9CI) is used as a key intermediate in the total synthesis of endothelin-converting enzyme (ECE) antagonists. These antagonists are important in the development of drugs for the treatment of various cardiovascular and cerebrovascular diseases, as they help regulate the activity of endothelin, a potent vasoconstrictor peptide.
In the synthesis process, 3,4-Dimethoxypyridine serves as a building block for the formation of more complex molecules with potential therapeutic effects. Its unique structure and reactivity make it a valuable component in the design and development of novel ECE antagonists, which can be tailored to target specific disease conditions and improve patient outcomes.

InChI:InChI=1/C7H9NO2/c1-9-6-3-4-8-5-7(6)10-2/h3-5H,1-2H3

Upstream product

• 101664-59-9 2-chloro-3,4-dimethoxypyridine 
• 186581-53-3 diazomethane 
• 210300-15-5 4-methoxy-3-methoxymethoxypyridine 
• 153199-54-3 3-hydroxy-4-methoxypyridine 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 10182-48-6 3,4-dihydroxypyridine 
• 101664-56-6 2-Chlor-3-fluor-4-nitropyridin-1-oxid 
• 101664-58-8 2-Chlor-3,4-dimethoxypyridin-1-oxid 
• 85386-94-3 2-Chlor-3-fluorpyridin-1-oxid 
• 17282-04-1 2-chloro-3-fluoropyridine 
• 620-08-6 4-methoxypyridine 

Downstream Products

• 107512-35-6 3,4-dimethoxy-2-methylpyridine 
• 104819-52-5 2-bromo-3,4-dimethoxy pyridine 
• 220437-83-2 3,4-dimethoxypicolinic acid 
• 188048-45-5 WS75624 B 
• 101664-59-9 2-chloro-3,4-dimethoxypyridine 
• 101664-55-5 3,3',4,4'-tetramethoxy-2,2'-bipyridine 

Relevant articles and documents

A concise approach towards the synthesis of WS75624 a and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles

Synthetic approach towards precursors of WS75624 A and WS75624 B, two potent endothelin converting enzyme (ECE) inhibitors and potential antihypertensive agents, is reported featuring a key cross-metathesis between a vinyl-functionalized thiazole and a terminal olefin. As the two natural products only differ by the nature of their hydroxyalkyl side-chain, our convergent strategy enable the synthesis of key intermediates of both molecules in a limited amount of steps.

First synthesis of 4-chloro-2,2-difluoro[1,3]dioxole[4,5-c]pyridine

The 2,2-difluorobenzodioxole moiety has been introduced in medicinal chemistry research as a potential metabolically more stable derivative of the benzodioxole fragment. Herein we present, to the best of our knowledge, the first synthesis of 4-chloro-2,2-

New Synthesis of Orelline by Metalation of Methoxypyridines

A new total synthesis in five steps of alkaloid Orelline is reported.The methodology involves metalation of methoxypyridines to afford 2-halo-3,4-dimethoxypyridine on which an homocoupling reaction is performed to build the 2,2'-bipyridyl structure of the

Syntheses of Hydroxylated Bipyridines, I. - Orellanine, the Poison of a Toadstool

Two syntheses of orellanine, -3,3',4,4'-tetrol-1,1'-dioxide (5b), are developed which comprise 10 or 11 steps, respectively.The chemical reactions of 5b with diazomethane and on UV irradiation are described.