111504-19-9

Basic information

• Product Name: CYCLOHEXYL 2-METHOXYPHENYL KETONE
• Synonyms: CYCLOHEXYL 2-METHOXYPHENYL KETONE
• CAS NO: 111504-19-9
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.29
• Mol File: 111504-19-9.mol

Chemical Properties

• Boiling Point: 330.8°C at 760 mmHg
• Flash Point: 140.6°C
• Appearance: /
• Density: 1.052g/cm³
• Vapor Pressure: 0.000162mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: CYCLOHEXYL 2-METHOXYPHENYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXYL 2-METHOXYPHENYL KETONE(111504-19-9)
• EPA Substance Registry System: CYCLOHEXYL 2-METHOXYPHENYL KETONE(111504-19-9)

Safety Data

• Hazardous Substances Data: 111504-19-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H18O2/c1-16-13-10-6-5-9-12(13)14(15)11-7-3-2-4-8-11/h5-6,9-11H,2-4,7-8H2,1H3

Upstream product

• 100-66-3 methoxybenzene 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 110-82-7 cyclohexane 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 135-02-4 ortho-anisaldehyde 
• 98-89-5 Cyclohexanecarboxylic acid 

Downstream Products

• 1417652-29-9 (E)-N′-(cyclohexyl(2-methoxyphenyl)methylene)-4-methylbenzenesulfonohydrazide 

Relevant articles and documents

Rapid and Direct Photocatalytic C(sp3)?H Acylation and Arylation in Flow

Herein, we report a photocatalytic procedure that enables the acylation/arylation of unfunctionalized alkyl derivatives in flow. The method exploits the ability of the decatungstate anion to act as a hydrogen atom abstractor and produce nucleophilic carbon-centered radicals that are intercepted by a nickel catalyst to ultimately forge C(sp3)?C(sp2) bonds. Owing to the intensified conditions in flow, the reaction time can be reduced from 12–48 hours to only 5–15 minutes. Finally, kinetic measurements highlight how the intensified conditions do not change the reaction mechanism but reliably speed up the overall process.

Synthesis of Ketones through Microwave Irradiation Promoted Metal-Free Alkylation of Aldehydes by Activation of C(sp3)-H Bond

In this paper, a novel methodology for the synthesis of ketones via microwave irradiation promoted direct alkylation of aldehydes by activation of the inert C(sp3)-H bond has been developed. Notably, the reactions were accomplished under metal-free conditions and used commercially available aldehydes and cycloalkanes as substrates without prefunctionalization. By using this novel method, an alternative synthetic approach toward the key intermediates for the preparation of the pharmaceutically valuable oxaspiroketone derivatives was successfully established.

Palladium-catalyzed acylative cross-coupling of amides with diarylborinic acids and sodium tetraarylborates

Abstract A general and efficient acylative Suzuki coupling of active amides with diarylborinic acids has been achieved by using 1 mol% Pd(PCy3)2Cl2/0.6 mol% PCy3 as catalyst system taking advantage of modifiable reactivities of acyl-nitrogen bonds of amides. Both electronic and steric influences from either aryl or acyl counterparts on the coupling proved to be negligible or small. A variety of aryl ketones including sterically hindered ones could be synthesized by the coupling of diarylborinic acids in good to excellent yields. Sodium tetraarylborates could also be used as high atom-economy aryl source in the palladium-catalyzed cross-coupling with active amides.

Friedel-Crafts Acylation of Arenes Catalysed by Bromopentacarbonylrhenium(I)

The intermolecular Friedel-Crafts acylation of aromatic compounds (such as toluene, m-xylene, and anisole) with various acid chlorides proceeds by using a catalytic amount of bromopentacarbonylrhenium(I) to afford aryl ketones.Intramolecular acylation is also catalyzed by the above-mentioned catalyst to give indanone and tetralone derivatives.