112006-58-3Relevant articles and documents
Preparation method of 2-aminosulfonyl-N, N-dimethyl nicotinamide
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, (2021/05/19)
The invention provides a preparation method of 2-aminosulfonyl-N, N-dimethyl nicotinamide. The preparation method comprises the following steps: synthesizing 2-chlorine-N, N-dimethyl nicotinamide by taking 2-cyano-5-dimethylamino-2, 4-pentadienyl dicarboxamide and hydrochloric acid gas as raw materials, and reacting at the temperature of between 0 and 100 DEG C to synthesize the 2-chloro-N, N-dimethyl nicotinamide. Furthermore, the preparation method provided by the invention also comprises the step of sequentially synthesizing the 2-sulfydryl-N, N-dimethyl nicotinamide, the 2-chlorosulfonyl-N, N-dimethyl nicotinamide and the 2-aminosulfonyl-N, N-dimethyl nicotinamide by taking the 2-chloro-N, N-dimethyl nicotinamide as a raw material. According to the preparation method of the 2-aminosulfonyl-N, N-dimethyl nicotinamide, provided by the invention, the novel preparation method is provided by taking the 2-cyano-5-dimethylamino-2, 4-pentadiene dicarboxamide as an initial raw material, and the preparation method is relatively short in synthetic route, relatively high in yield and relatively low in cost.
Method for closed-loop synthesis of nicosulfuron by using hydrogen sulfide
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, (2021/10/05)
The invention belongs to the technical field of nicosulfuron original medicine production, and particularly relates to a method for closed-loop synthesis of nicosulfuron by using hydrogen sulfide, wherein the method comprises the following steps: reacting tetramethoxypropane with ethyl cyanoacetate to generate 1-cyano-4-methoxy-1-ethoxycarbonyl-1,3-butadiene (cyanoene for short, the same below); reacting cyano alkene with hydrogen sulfide to generate ethyl 2-mercaptonicotinate (sulfydryl substance for short) in a closed-loop manner; reacting the sulfydryl substance with dimethylamine, and then carrying out oxychlorination reaction to obtain sulfonyl chloride; carrying out ammonolysis reaction on the sulfonyl chloride and ammonia gas to obtain sulfonamide; and reacting sulfonamide with solid light and pyrilamine to obtain the nicosulfuron. According to the method for closed-loop synthesis of nicosulfuron by using hydrogen sulfide, each reaction step is mild and controllable, process equipment is simple, the production cost is low, the product quality is good, three wastes are reduced, energy is saved, the production environment is improved, and the goal of carbon neutralization is favorably realized.
Preparation method of nicosulfuron crude drug
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Paragraph 0020; 0021; 0026; 0027; 0031; 0032, (2020/03/23)
The preparation method, of the nicosulfuron crude drug comprises the following steps: synthesizing, isocyanate group sulfonyl - NNNN, N-dimethyl nicotinamide: triphosgene 2 - triethylamine and 2 - amino - 4444, 6-dimethoxypyrimidine as main raw materials in, reaction to synthesize nicosulfuron-N, N-dimethylnicotinamide 0-80 °C and 2 - amino - 4444, 6-dimethoxypyrimidine as main raw materials to synthesize nicosulfuron-N, N-dimethylaminopyridine as a main, raw material, and high yield; of nicosulfuron. 2 - The method provided by the invention comprises the following steps, synthesizing 2 - 2 -isocyanuric acid group, sulfonyl - NNNNor N-dimethylaminopyrimidinil in 0-100 °C reaction to form a nicosulfuron prodrug. by reacting. 2 - The preparation method comprises the following. steps, synthesizing nicosulfuron-N, N-dimethyl nicotinamide.
Preparation method of 2-aminosulfonyl-N,N-dimethylnicotinamide
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Paragraph 0060; 0063; 0064; 0065; 0066, (2017/04/12)
The invention provides a preparation method of 2-aminosulfonyl-N,N-dimethylnicotinamide. With 2-aminonicotinic acid serving as the raw material, 2-aminosulfonyl-N,N-dimethylnicotinamide is prepared through the first step of conducting a chloroformylation reaction and an amination reaction, the second step of conducting a diazotization reaction, the third step of conducting a Sandmeyer reaction and the fourth step of conducting an amination reaction. The preparation method has the advantages that reaction conditions are mild, stable and controllable, side reactions are not likely to occur as the number of active sites is small, and the whole route is high in yield and quality; cost can be effectively reduced as original materials can be easily obtained from the market, and the preparation method is environmentally friendly as no polysulfide is used.
Mercapto-substituted pyridine compounds, aminocarbonyl-substituted pyridinesulfinic acid compounds and process for preparing the same
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, (2008/06/13)
An aminocarbonyl-substituted pyridinesulfinic acid intermediate for production of an herbicide having formula (V): STR1 wherein R3 and R4 are selected from the group consisting of hydrogen and alkyl groups, or a salt thereof. The aminocarbonyl-substituted pyridinesulfinic acid or salt thereof is useful as the precursor of aminosulfonyl-substituted pyridinecarbonic acid amide, which in turn is useful as the starting material for agricultural chemicals, medicine, etc.
Mercapto-substituted pyridine compounds
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, (2008/06/13)
A mercapto-substituted pyridine compound having formula (I): STR1 where R1 and R2 are alkyl groups, and n is 0 or 1, and salts thereof and a process for preparing the same are disclosed. The mercapto-substituted pyridine compound is useful as an intermediate for preparing a herbicidal compound. The present invention further provides aminocarbonyl-substituted pyridinesulfinic acid (ACPS) or salts thereof as the precursor of aminosulfonyl-substituted pyridinecarbonic acid amide compound (APCA) which is useful as the starting material for agricultural chemicals, medicine, etc. Moreover, the preparation process of the present invention is an industrially advantageous preparation process which is capable of preparing in a series of steps from mercapto-substituted pyridinecarboxylic acid amide compound (MPCA) or aminocarbonyl-substituted halogenopyridine compound (ACHP) to ACPS or salts thereof, and further to APCA.
