52943-21-2

Basic information

• Product Name: 2-CHLORO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE
• Synonyms: 2-CHLORO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE;N,N-DIMETHYL 2-CHLORO NICOTAMIDE;2-Chloro-N,N-dimethylnicotinamide;2-chloro-N,N-dimethylnicotinamide(SALTDATA: FREE)
• CAS NO: 52943-21-2
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.62286
• Product Categories: pharmacetical;alkyl chloride
• Mol File: 52943-21-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 63-65℃
• Boiling Point: 330.673 °C at 760 mmHg
• Flash Point: 153.786 °C
• Appearance: /
• Density: 1.232 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: 2-8°C
• PKA: -0.95±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE(52943-21-2)
• EPA Substance Registry System: 2-CHLORO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE(52943-21-2)

Safety Data

• Hazardous Substances Data: 52943-21-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-N,N-dimethyl-3-pyridinecarboxamide is a chemical compound with the molecular formula C8H10ClN2O. It exists as a crystalline solid under standard conditions and is primarily used in the field of chemistry and pharmaceuticals. It is an important reagent and intermediate in the synthesis of various bioactive compounds and drugs. As its name suggests, this compound contains a pyridine carboxamide group, which is a nitrogen-containing heterocycle, along with a chloro substituent, which adds to its reactivity. Its properties like solubility, stability, and reactivity would much depend on the conditions such as temperature, solvent, and pH. Like many chemicals, careful handling and appropriate safety measures are required when dealing with this compound due to its potential hazards.

InChI:InChI=1/C8H9ClN2O/c1-11(2)8(12)6-4-3-5-10-7(6)9/h3-5H,1-2H3

Upstream product

• 49609-84-9 2-Chloronicotinoyl chloride 
• 124-40-3 dimethyl amine 
• 7391-40-4 N,N-dimethylcyanoacetamide 
• 506-59-2 N,N-dimethylammonium chloride 
• 40134-18-7 methyl 2-chloropyridine-3-carboxylate 
• 2942-59-8 2-chloronicotinic acid 

Downstream Products

• 112006-57-2 N,N-dimethyl-2-(phenylmethylthio)-3-pyridinecarboxamide 
• 112006-58-3 2-sulfonyl chloride-N,N-dimethylnicotinamide 
• 112006-75-4 N,N-dimethyl-2-(aminosulfonyl)-3-pyridinecarboxamide 
• 111991-09-4 nicosulfuron 
• 6972-69-6 N,N-dimethylnicotinamide 

Relevant articles and documents

Unexpectedly produced 2-tert-butyl-5-(N,N-dimethylcarbamoyl)pyridine from 2-chloro-3-(N,N-dimethylcarbamoyl)-pyridine with a tert-butyl Grignard reagent

The title compound, C12H18N2O, was obtained by the reaction of 2-chloro-3-(N,N-dimethylcarbamoyl)pyridine with tert-butylmagnesium chloride. The structure was confirmed by NMR spectroscopy and X-ray crystallography.

Preparation method 2 - chlorine - N, N - dimethyl nicotinamide

The invention provides a preparation method for 2-chloro-N,N-dimethylnicotinamide. The preparation method comprises the following steps: subjecting disubstituted amidoacrolein and 2-cyano-N,N-dimethylacetamide to a Knoevenagel reaction under the catalysis of a catalyst; and reacting a target intermediate obtained in the previous step with hydrogen chloride gas so as to obtain 2-chloro-N,N-dimethylnicotinamide. The catalyst used in the invention can greatly improve the yield of the Knoevenagel reaction, wherein the yield can reach 97% or above, and the content of 2-chloro-N,N-dimethylnicotinamide reaches 97% or above. The preparation method uses easily available raw materials, is simple to operate, improves reaction yield, avoids usage of reagents with severe toxicity, i.e., phosphorous oxychloride and thionyl chloride, reduces production cost, and is low in the discharge of waste gas, waste water and industrial residues, friendly to environment and suitable for industrial production.

Synthesis method of 2-chloro-N, N-dimethylnicotinamide

The invention relates to a synthesis method of 2-chloro-N, N-dimethylnicotinamide, and belongs to the technical field of pesticides. According to the method, 2-chloronicotinic acid is used as a starting raw material, 2-chloronicotinyl chloride is obtained through an acylation reaction, and then 2-chloronicotinyl chloride reacts with dimethylamine hydrochloride to obtain 2-chloro-N, N-dimethylnicotinamide. In the process of preparing the 2-chloro-N, N-dimethylnicotinamide from the 2-chloronicotinyl chloride, dimethylamine hydrochloride is used as an aminating agent. Dimethylamine hydrochlorideis solid and is more convenient to use than methylamine aqueous solution and methylamine gas. In terms of the use amount of dimethylamine, the molar ratio of the use amount of 2-chloro-N, N-dimethylnicotinamide to 2-chloronicotinoyl chloride is 1.1-1.4 eq, and only a small amount is excessive, so that the residue of dimethylamine is directly and fundamentally reduced, the difficulty of dimethylamine wastewater treatment is reduced, and the production cost is reduced.