113884-71-2Relevant articles and documents
TERTIARY AMIDES AND METHOD OF USE
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Paragraph 00578; 00579, (2017/11/04)
Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
A concise synthesis of enantiopure circumdatins E, H and J
Zhichkin, Paul E.,Jin, Xiaomin,Zhang, Honglu,Peterson, Lisa H.,Ramirez, Catherine,Snyder, Tara M.,Burton, Hilde S.
supporting information; experimental part, p. 1287 - 1289 (2010/06/17)
A concise total synthesis of enantiopure circumdatins E, H and J has been developed using a reductive cyclization of chiral N-prolinoyl-2-nitrobenzamides to construct the core quinazolinone ring.
Buttressing and Electronic Effects of meta- and para-Methoxy Substituents on the Configurational Stability of 5,7-Dihydro-1,11-dimethoxydibenzoxepine
Insole, Joan M.
, p. 2831 - 2867 (2007/10/02)
Three methoxy-substituted 5,7-dihydrodibenzoxepines have been prepared, each in both enantiomeric forms: (-)- and (+)-5,7-dihydro-1,3,9,11-tetramethoxydibenzoxepine (12) starting from, respectively, (+)- and (-)-4,4',6,6'-tetramethoxydiphenic acid (16); (+)- and (-)-5,7-dihydro-1,2,10,11-tetramethoxydibenzoxepine (13) from, respectively, (+)- and (-)-5,5',6,6'-tetramethoxydiphenic acid (25); and (R)-(+)- and (S)-(-)-5,7-dihydro-1,2,3,9,10,11-hexamethoxydibenzoxepine (14) from, respectively, (R)-(+)- and (S)-(-)-4,4',5,5',6,6'-hexamethoxydiphenic acid (30).The previously unpublished resolutions of 4,4',6,6'-tetramethoxydiphenic acid (16) and 5,5',6,6'-tetramethoxydiphenic acid (25) are described.Racemisation parameters for the three 5,7-dihydrodibenzoxepines have been determined and are compared with those for 5,7-dihydro-1,11-dimethoxydibenzoxepine (11).The buttressing effects of the meta-methoxy substituents, and the electronic effects of the para-methoxy substituents on the optical stabilities of the 5,7-dihydrodibenzoxepines are discussed, as are the u.v., and 1H and 13C n.m.r. spectra of these bridged biphenyls.
Alkaloids from Annonaceae 93. First synthesis of a meta-disubstituted aporphine
Roblot, F.,Hocquemiller, R.,Cave, A.
, p. 258 - 267 (2007/10/02)
The synthesis of a new aporphinoid alkaloid, substituted on the 9 and 11 positions, is reported.An unexpected reactivity has been observed for several intermediates.It has been attributed to the position of the methoxy groups with regard to the nitro group.
