114079-04-8

Basic information

• Product Name: DT-ME PHOSPHONAMIDITE
• Synonyms: DT-ME PHOSPHONAMIDITE;DT-METHYL PHOSPHONAMIDITE
• CAS NO: 114079-04-8
• Molecular Formula: C₃₈H₄₈N₃O₇P
• Molecular Weight: 689.78
• Mol File: 114079-04-8.mol

Chemical Properties

• Appearance: /
• PKA: 9.55±0.10(Predicted)
• CAS DataBase Reference: DT-ME PHOSPHONAMIDITE(CAS DataBase Reference)
• NIST Chemistry Reference: DT-ME PHOSPHONAMIDITE(114079-04-8)
• EPA Substance Registry System: DT-ME PHOSPHONAMIDITE(114079-04-8)

Safety Data

• Hazardous Substances Data: 114079-04-8(Hazardous Substances Data)

Upstream product

• 114591-59-2 Bis-(4-methoxy-phenyl)-pyren-1-yl-methanol 
• 114601-67-1 1,1-bis-(4-methoxyphenyl)-1'-pyrenyl-methyl-chloride 
• 108-18-9 diisopropylamine 
• 110838-39-6 N,N,N',N'-Tetraisopropyl-P-methylphosphonous diamide 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 114591-62-7 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-pyren-1-yl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 51747-24-1 N,N-diisopropylamino methylphosphonamidic chloride 
• 56183-63-2 bis(diisopropylamino)chlorophosphine 
• 137564-78-4 N,N-diisopropyl-O-p-nitrophenyl-P-methylphosponoamidite 

Downstream Products

• 90814-42-9 5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate 
• 137537-68-9 C₆₃H₆₅N₄O₁₄PS 
• 90814-44-1 C₆₃H₆₅N₄O₁₅P 
• 142183-02-6 C₆₃H₆₀N₇O₁₃PS 
• 142182-99-8 C₆₃H₆₀N₇O₁₄P 
• 142183-05-9 Methyl-phosphonic acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 191474-13-2 5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydrothymidine 
• 40615-39-2 1-((2R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)- dione 
• 112514-65-5 5'-O-(dimethoxytrityl)thymidine 3'-O-(2''-cyanoethylmethylphosphonothioate) 
• 75715-13-8 C₄₂H₄₇N₄O₁₃P 
• 195307-35-8 (Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate 
• 129398-92-1 C₄₄H₄₉N₄O₁₃P 

Relevant articles and documents

Synthesis of Alkylphosphon(othio)ate Analogues of DNA

Easily accessible bis(diisopropylamino)alkylphosphines (alkyl is methyl, n-butyl or n-octyl) are convenient reagents for the synthesis of DNA fragments having an alkylphosphonate or alkylphosphonothioate linkage at a predetermined site in solution and on

N,N-diisopropyl-O-P-nitrophenyl-P-methylphosphonoamidite: Novel difunctional PIII reagent in oligonucleoside methylphosphonate synthesis containing 4-nitrophenoxy group

First example of the PIII coupling reagent containing 4-nitrophenoxy group is described. Its usefulness is demonstrated by synthesis of dinucleoside methylphosphonate and methylthiophosphonate.

OLIGODEOXYNUCLEOSIDE METHYLPHOSPHONATES: SYNTHESIS AND ENZYMIC DEGRADATION

The automated synthesis of oligodeoxynucleosides containing methylphosphonate linkages has been improved by using nucleoside methylphosphonamidites as starting materials.It was found that two adjacent methylphosphonate linkages protect an oligomer from degradation by snake venom phosphodiesterase or spleen phosphodiesterase.

PHOSPHORAMIDITES AS SYNTHONS FOR POLYNUCLEOTIDE SYNTHESIS

Methods for the rapid synthesis of DNA and RNA are described.The procedures involve using nucleoside phosphoramidites as synthons and silica as a polymeric support.Additionally, a novel reaction involving nucleoside O-alkyl methylphosphonothioates is described.