114745-46-9

Basic information

• Product Name: (1R,2R)-ethyl 2-aMinocyclopentanecarboxylate
• Synonyms: (1R,2R)-ethyl 2-aMinocyclopentanecarboxylate;ethyl (1R,2R)-2-aminocyclopentane-1-carboxylate
• CAS NO: 114745-46-9
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.2102
• Mol File: 114745-46-9.mol

Chemical Properties

• Boiling Point: 213.4±33.0 °C(Predicted)
• Appearance: /
• Density: 1.045±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.10±0.40(Predicted)
• CAS DataBase Reference: (1R,2R)-ethyl 2-aMinocyclopentanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-ethyl 2-aMinocyclopentanecarboxylate(114745-46-9)
• EPA Substance Registry System: (1R,2R)-ethyl 2-aMinocyclopentanecarboxylate(114745-46-9)

Safety Data

• Hazardous Substances Data: 114745-46-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Manufacturing:
(1R,2R)-ethyl 2-aminocyclopentanecarboxylate is used as an intermediate for the synthesis of various pharmacologically active compounds, leveraging its unique structure and functional groups to create novel drug candidates.
Used in Organic Synthesis:
It serves as a building block in organic synthesis, where its stereochemistry and functional groups are utilized to construct complex organic molecules with specific properties.
Used in Drug Property Modification:
(1R,2R)-ethyl 2-aminocyclopentanecarboxylate is used to modify the properties of existing drugs, enhancing their efficacy, stability, or bioavailability through chemical manipulation.
Used in Stereochemistry and Organic Reaction Mechanism Studies:
Its unique structure makes (1R,2R)-ethyl 2-aminocyclopentanecarboxylate a useful tool for researchers studying stereochemistry and the mechanisms of organic reactions, contributing to a deeper understanding of chemical processes and the development of new synthetic methods.

Upstream product

• 1033755-97-3 2-benzylamino-cyclopentanecarboxylic acid ethyl ester 
• 7149-18-0 ethyl 2-amino-1-cyclopentene-1-carboxylate 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 142-29-0 cyclopentene 
• 64-17-5 ethanol 
• 22031-52-3 cis-2-aza-3-oxobicyclo<3.2.0>heptane 

Downstream Products

• 197916-36-2 ethyl (1R,2S)-2-aminocyclopentane-1-carboxylate 
• 135053-11-1 cis-2-amino-1-cyclopentanecarboxamide 
• 135053-11-1 trans-2-aminocyclopentanecarboxamide 
• 128668-89-3 cis-3-phenyl-1,2,3,4a,5,6,7,7a-octahydrocyclopentapyrimidine-2,4-dione 
• 158262-07-8 ethyl cis-2-benzylamino-1-cyclopentanecarboxylate 
• 311341-94-3 ethyl cis-2-isothiocyanato-1-cyclopentanecarboxylate 
• 141045-77-4 Ethyl trans-2-(N-Benzylamino)cyclopentanecarboxylate 

Relevant articles and documents

SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF

Compounds of formula (I), processes for their production and their use as pharmaceuticals.

Diastereoselective Photoredox-Catalyzed [3 + 2] Cycloadditions of N-Sulfonyl Cyclopropylamines with Electron-Deficient Olefins

A highly diastereoselective, visible-light-induced [3 + 2] cycloaddition between N-sulfonyl cyclopropylamines and electron-deficient olefins is reported. The reactions proceed via the oxidation of a sulfonamide aza-anion by an organic photocatalyst to generate a nitrogen-centered radical. Strain-induced ring opening and intermolecular addition to the olefin generate an intermediate carbon-centered radical that is reduced to an anion prior to 5-exo cyclization. This enables a highly diastereoselective construction of trans-cyclopentanes possessing synthetically useful functional groups.

Dirhodium(II)-Catalyzed (3 + 2) Cycloaddition of the N-Arylaminocyclopropane with Alkene Derivatives

Several (3 + 2) cycloaddition reactions catalyzed by dirhodium(II) complexes between N-arylaminocyclopropane and alkenes derivative have been developed. Preliminary mechanism studies suggest that dirhodium(II) complexes may decrease the bond-dissociation

Synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols or 3-amino alcohols using iodobenzene dichloride and sodium azide

A general and efficient method for the synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols and 3-amino alcohols has been developed using the same reagent combination of iodobenzene dichloride (PhICl2) and sodium azide (NaN3).

Expanding dynamic kinetic protocols: Transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

Several α-alkylated β-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic α-alkyl-β-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic β-keto esters high to excellent inductions were obtained.