1152313-76-2

Usage

Uses

Used in Asymmetric Catalysis:
(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole is used as a practical equivalent to t-Bu-PHOX in asymmetric catalysis. Its unique molecular structure allows it to serve as an effective catalyst in various chemical reactions, enhancing the enantioselectivity and efficiency of the process.
Used in Pd-Catalyzed Asymmetric Transformations:
(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole is also utilized in the design, synthesis, and application of potential substitutes for t-Bu-Phosphinooxazoline in Pd-catalyzed asymmetric transformations. Its ability to improve the enantioselectivity in these reactions makes it a valuable tool in the development of new and improved chemical processes.
Used in the Pd-Catalyzed Allylation Reaction of Fluorinated Allyl Enol Carbonates:
(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole is used as a catalyst in the Pd-catalyzed allylation reaction of fluorinated allyl enol carbonates. Its presence in the reaction can lead to improved enantioselectivity, which is crucial for the production of chiral compounds with specific biological activities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole may be used as a key intermediate in the synthesis of various drugs and drug candidates. Its unique properties and reactivity can contribute to the development of new therapeutic agents with improved efficacy and selectivity.
Used in Chemical Research and Development:
(4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-5,5-diMethyl-4-(1-Methylethyl)-oxazole is also valuable in the field of chemical research and development, where it can be used to explore new reaction pathways, develop novel catalysts, and create innovative synthetic methods. Its unique structure and reactivity make it a promising candidate for further investigation and application in various chemical processes.

Upstream product

• 1152313-75-1 (S)-2-(2-fluorophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole 
• 829-85-6 diphenylphosphane 
• 1152313-78-4 (S)-2-(2-bromophenyl)-4-isopropyl-5,5-dimethyl-4,5-dihydrooxazole 
• 1152313-74-0 (S)-2-fluoro-N-(2-hydroxy-2,4-dimethylpentan-3-yl)benzamide 
• 1152313-77-3 (S)-2-bromo-N-(2-hydroxy-2,4-dimethylpentan-3-yl)benzamide 
• 72-18-4 L-valine 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 
• 6306-52-1 L-valine methylester hydrochloride 
• 157035-77-3 tert-butyl (S)-(2-hydroxy-2,4-dimethylpentan-3-yl)carbamate 

Relevant academic research and scientific papers

Design, synthesis, and applications of potential substitutes of t-Bu-phosphinooxazoline in Pd-catalyzed asymmetric transformations and their use for the improvement of the enantioselectivity in the Pd-catalyzed allylation reaction of fluorinated allyl enol carbonates

The design, synthesis, and applications of potential substitutes of t-Bu-PHOX in asymmetric catalysis is reported. The design relies on the incorporation of geminal substituents at C5 in combination with a substituent at C4 other than t-butyl (i-Pr, i-Bu, or s-Bu). Most of these new members of the PHOX ligand family behave similarly in terms of stereoinduction to t-Bu-PHOX in three palladium-catalyzed asymmetric transformations. Electronically modified ligands were also prepared and used to improve the enantioselectivity in the Pd-catalyzed allylation reaction of fluorinated allyl enol carbonates.

Use of 5,5-(dimethyl)-i-Pr-PHOX as a practical equivalent to t-Bu-PHOX in asymmetric catalysis

The use of 5,5-(dimethyl)-i-Pr-PHOX as a practical equivalent of t-Bu-PHOX in asymmetric catalysis is reported. This new member of the phosphinooxazoline (PHOX) ligand family behaves similarly in terms of stereoinduction to t-Bu-PHOX with the key advantage of being readily accessible as both enantiomers starting from either(S)- or (R)-valine.