116435-75-7

Basic information

• Product Name: 3-ethoxy-4-nitroaniline
• Synonyms: 3-ethoxy-4-nitroaniline;Benzenamine, 3-ethoxy-4-nitro-
• CAS NO: 116435-75-7
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.1766
• Mol File: 116435-75-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-ethoxy-4-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethoxy-4-nitroaniline(116435-75-7)
• EPA Substance Registry System: 3-ethoxy-4-nitroaniline(116435-75-7)

Safety Data

• Hazardous Substances Data: 116435-75-7(Hazardous Substances Data)

Upstream product

• 2369-13-3 3-fluoro-4-nitroaniline 
• 141-52-6 sodium ethanolate 
• 591-33-3 3-ethoxyacetanilide 
• 361162-91-6 5-ethoxy-2-methyl-4-nitroacetanilide 
• 361162-90-5 5-methoxy-2-methyl-4-nitroacetanilide 
• 106579-00-4 5-methoxy-2-methyl-4-nitroaniline 
• 133070-80-1 2-(ethyloxy)-1,4-dinitrobenzene 
• 361162-92-7 2-acetylamino-4-ethoxy-5-nitrobenzoic acid 
• 871895-08-8 acetic acid-(3-ethoxy-4-nitro-anilide) 

Downstream Products

• 492456-51-6 (E)-2-Cyano-3-(3-ethoxy-4-nitro-phenylamino)-acrylic acid ethyl ester 
• 214476-09-2 4-Chloro-7-ethoxy-6-nitro-quinoline-3-carbonitrile 
• 214476-08-1 7-Ethoxy-4-hydroxy-6-nitro-quinoline-3-carbonitrile 
• 214485-69-5 6-amino-4-(3-bromo-phenylamino)-7-ethoxy-quinoline-3-carbonitrile 
• 214485-68-4 4-(3-Bromo-phenylamino)-7-ethoxy-6-nitro-quinoline-3-carbonitrile 
• 361162-95-0 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile 
• 492456-86-7 N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-2-butenamide 
• 257933-82-7 pelitinib 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION, AND APPLICATION

A nitrogenous heterocyclic compound, a preparation method, an intermediate, a composition, and an application. The present invention provides a nitrogenous heterocyclic compound as represented by formula I, pharmaceutically acceptable salts thereof, enantiomers thereof, diastereoisomers thereof, tautomers thereof, solvates thereof, metabolites thereof, or prodrugs thereof. The compound has high inhibitory activity against ErbB2 tyrosine kinase, has good inhibitory activity against human breast cancer cells BT-474, human gastric cancer cells NCI-N87 and the like with high expression of ErbB2, and in addition has relatively weak inhibitory activity against EGFR kinase, that is, the compound is an EGFR/ErbB2 double target inhibitor that attenuates EGFR kinase inhibitory activity or a small-molecule inhibitor having selectivity for an ErbB2 target. (I)

A convenient method to aniline compounds using microwave-assisted transfer hydrogenation

The reduction of mononitro and dinitro aromatic compounds to their aniline analogues using microwave-assisted transfer hydrogenation has been demonstrated. The optimised conditions used, with some examples, are described herein. Georg Thieme Verlag Stuttgart.

USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS

This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula (1); wherein R1, R2, R3, R4, X, Y, and n are defined hereinbefore, or a pharmaceutically acceptable salt thereof.

Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epi

A series of of 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile derivatives that function as irreversible inhibitors of EGFR and HER-2 kinases have been prepared. These inhibitors have, at the 6-position, butynamide, crotonamide, and methacrylamide Mic

Method of treating or inhibiting colonic polyps

This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula 1 wherein:R1, R2, R3, R4, X, Y, and n are as defined hereinbefore, or a pharmaceutically acceptable salt thereof.