117069-75-7

Basic information

• Product Name: 3-AMINOINDOLIN-2-ONE
• Synonyms: CHEMBRDG-BB 4011261;AKOS BB-9966;3-AMINOINDOLIN-2-ONE;3-amino-1,3-dihydro-2H-indol-2-one(SALTDATA: HCl)
• CAS NO: 117069-75-7
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Mol File: 117069-75-7.mol

Chemical Properties

• Boiling Point: 323.7°Cat760mmHg
• Flash Point: 149.6°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 0.000257mmHg at 25°C
• PKA: 14.05±0.40(Predicted)
• CAS DataBase Reference: 3-AMINOINDOLIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINOINDOLIN-2-ONE(117069-75-7)
• EPA Substance Registry System: 3-AMINOINDOLIN-2-ONE(117069-75-7)

Safety Data

• Hazardous Substances Data: 117069-75-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
3-AMINOINDOLIN-2-ONE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and functional groups enable the development of new drugs with diverse pharmacological activities.
Used in Organic Synthesis:
3-AMINOINDOLIN-2-ONE serves as a versatile building block in organic synthesis, allowing for the creation of a wide range of chemical compounds with potential applications in various industries.
Used in Anticancer Applications:
3-AMINOINDOLIN-2-ONE is used as an anticancer agent due to its biological activity. It has been found to exhibit anticancer properties, making it a promising candidate for the development of new cancer treatments.
Used in Antifungal Applications:
3-AMINOINDOLIN-2-ONE also demonstrates antifungal properties, which can be utilized in the development of new agrochemicals and treatments for fungal infections.
Used in Drug Development:
Due to its diverse pharmacological activities, 3-AMINOINDOLIN-2-ONE has potential applications in the development of new drugs for various therapeutic areas, including oncology and anti-infective therapies.

InChI:InChI=1/C8H8N2O/c9-7-5-3-1-2-4-6(5)10-8(7)11/h1-4,7H,9H2,(H,10,11)/p+1/t7-/m0/s1

Upstream product

• 607-28-3 (E)-1H-indole-2,3-dione 3-oxime 
• 3265-35-8 indoline-2,3-dione-2-oxime 
• 91-56-5 indole-2,3-dione 
• 67-56-1 methanol 
• 612-53-3 (E)-3-iminoindolin-2-one 
• 1165809-20-0 indole-2,3-dione 3-thiosemicarbazone 

Downstream Products

• 91-56-5 indole-2,3-dione 
• 476-34-6 isoindigo 

Relevant articles and documents

Transaminative Desilylation of (Aminomethyl)trimethylsilane and Transitory Inactivation of Plasma Amine Oxidase

(Aminomethyl)trimethylsilane (AMTMS), a compound which has previously been used as a probe for electron-transfer oxidation of amines, undergoes transaminative desilylation by active carbonyl reagents and induces a mechanism-based inactivation of the quinone-containing plasma amine oxidase.

Electrochemical characterization of isatin-thiosemicarbazone derivatives

Abstract: Herein, we have notably described the electrochemical behavior of four isatin-thiosemicarbazone derivatives. In this regard, cyclic voltammograms of isatin-3-thiosemicarbazone (ITSC), isatin-3-(N4-benzylthiosemicarbazone) (ITSC-Ph), 1-(5-nitro-2-oxoindolin-3-ylidene)thiosemicarbazide (NO2-ITSC) and 1-(5-nitro-2-oxoindolin-3-ylidene)-4-phenylthiosemicarbazide (NO2-ITSC-Ph) have demonstrated an irreversible oxidation process. More specifically, the generation of isatin and thiourea moieties as the final oxidation products was proposed. The cyclic voltammograms also demonstrate irreversible reduction processes of ITSC and ITSC-Ph in three steps. The proposed final products are 3-aminoindolin-2-one and thiourea moieties. In the cyclic voltammograms of NO2-ITSC and NO2-ITSC-Ph, five reduction processes were observed: three of them due to reduction of the nitro group. It was proposed that the formation of 5-hydroxyamino-3-iminoindolin-2-one and the thiourea moieties would be the final products. Graphic abstract: [Figure not available: see fulltext.] Electrochemical characterization of four isatin thiosemicarbazone derivatives is described. The compounds are irreversibly oxidized and reduced. Isatin moieties and thiourea are proposed to be the products generated after oxidation. Considering the reduction processes, the nitro group present at the isatin moiety is also reduced and influences the reduction products generated.