117284-59-0Relevant articles and documents
Rate constant for the ring opening of the 2,2-difluorocyclopropylcarbinyl radical
Tian, Feng,Dolbier Jr., William R.
, p. 835 - 837 (2000)
(figure presented) The rate constant for the unimolecular ring opening of the 2,2-difluorocyclopropylcarbinyl radical was determined via its competitive bimolecular trapping by TEMPO. The value of this rate constant (3.4 × 1011 s-1 a
FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
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Paragraph 0076, (2019/04/16)
The present invention provides a fluorine-containing triazolopyridine represented by formula (I) and a racemate, R-stereoisomer, S-stereoisomer, pharmaceutically acceptable salt, or mixture thereof. The triazolopyridine can be used as a positive allosteri
Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery
Bychek, Roman M.,Levterov, Vadym V.,Sadkova, Iryna V.,Tolmachev, Andrey A.,Mykhailiuk, Pavel K.
supporting information, p. 12291 - 12297 (2018/03/28)
Difluorocyclopropane-containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF3/NaI. Novel fluorinated acids, amines, amino acids, alcohols, ketones and sulfonyl chlorides were obtained.
POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS
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Paragraph 00781, (2017/07/06)
The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.
PIPERIDINE-DIONE DERIVATIVES
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Page/Page column 113; 114, (2015/11/10)
The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.
METHOD OF CONTROLLING LACTATE PRODUCTION WITH PIPERDINE-DIONE DERIVATIVES
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Page/Page column 101, (2015/11/10)
The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034
Bogen,Arasappan,Pan,Ruan,Padilla,Saksena,Girijavallabhan,Njoroge
scheme or table, p. 4219 - 4223 (2009/04/07)
Substitutions on the P1 cyclobutyl side chain of SCH 503034 were studied by introduction of hydroxyl and fluoro substituents. Additionally, effects of fluoro substitution on other P1 moieties were evaluated.
2-(2,2-Difluorocyclopropyl)alkyl esters, processes for their preparation and their use as insecticides and acaricides
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, (2008/06/13)
There are provided new 2-(2,2-difluorocyclopropyl)alkyl esters of general formula I STR1 in which Y, R1-7 and n have the meanings given in the description and processes for their preparation. The new compounds can be used to combat insects and