2-(2,2-Difluoro-cyclopropyl)-ethanol

Base Information

• Chemical Name: 2-(2,2-Difluoro-cyclopropyl)-ethanol
• CAS No.: 117284-59-0
• Molecular Formula: C₅H₈F₂O
• Molecular Weight: 122.115
• Mol file: 117284-59-0.mol

Synonyms:1,1-difluoro-2-(2'-hydroxy)ethyl-cyclopropane

Chemical Property of 2-(2,2-Difluoro-cyclopropyl)-ethanol

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

2-(2,2-Difluorocyclopropyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,2-Difluoro-cyclopropyl)-ethanol

There total 2 articles about 2-(2,2-Difluoro-cyclopropyl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2,2-difluorocyclopropyl)ethyl benzoate (117388-09-7) → 1,1-difluoro-2-(2'-hydroxy)ethyl-cyclopropane (117284-59-0)

Guidance literature:

With ethylmagnesium bromide; In diethyl ether; at 0 ℃;

DOI:10.1016/j.bmcl.2008.05.060

Reference yield: 70.0%

3-butenyl benzoate (18203-32-2) → 1,1-difluoro-2-(2'-hydroxy)ethyl-cyclopropane (117284-59-0)

Guidance literature:

3-butenyl benzoate; With sodium fluoride; trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate; at 125 ℃; for 12h; Inert atmosphere;

With sodium hydroxide; at 20 ℃; for 3h; Reflux; Inert atmosphere;

Reference yield: 100.0%

1,1-difluoro-2-(2'-hydroxy)ethyl-cyclopropane (117284-59-0) → 2-(2,2-difluorocyclopropyl)-acetic acid (123131-67-9)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In water; acetone; at 20 ℃; for 4h;

DOI:10.1021/ol005578s

upstream raw materials:

2-(2,2-difluorocyclopropyl)ethyl benzoate

3-butenyl benzoate

Downstream raw materials:

2-(2,2-difluorocyclopropyl)-acetic acid

2-(2,2-Difluorocyclopropyl)ethyl 3,4-dichlorophenylcarbamate

Refernces

• 1、 -. "FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF". Paragraph 0076. . Retrieved 2019/04/16.
• 2、 -. "POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS". Paragraph 00781. . Retrieved 2017/07/06.