117388-09-7

Basic information

• Product Name: 2-(2,2-difluorocyclopropyl)ethyl benzoate
• Synonyms: 2-(2,2-difluorocyclopropyl)ethyl benzoate
• CAS NO: 117388-09-7
• Molecular Weight: 226.223
• Mol File: 117388-09-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-(2,2-difluorocyclopropyl)ethyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,2-difluorocyclopropyl)ethyl benzoate(117388-09-7)
• EPA Substance Registry System: 2-(2,2-difluorocyclopropyl)ethyl benzoate(117388-09-7)

Safety Data

• Hazardous Substances Data: 117388-09-7(Hazardous Substances Data)

Upstream product

• 18203-32-2 3-butenyl benzoate 
• 120801-75-4 trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate 
• 1895-39-2 sodium chlorodifluoroacetate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 98-88-4 benzoyl chloride 
• 111-66-0 oct-1-ene 

Downstream Products

• 123131-67-9 2-(2,2-difluorocyclopropyl)-acetic acid 
• 117284-59-0 1,1-difluoro-2-(2'-hydroxy)ethyl-cyclopropane 

Relevant articles and documents

A novel and highly efficient synthesis of gem-difluorocyclopropanes

(Formula presented) A new and highly versatile source of difluorocarbene is reported. Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) undergoes decomposition in the presence of catalytic fluoride to form difluorocarbene under conditions that allow its addition to relatively electron deficient alkenes in high yield. For example, unprecedented CF2: addition to n-butyl acrylate proceeded in 73percent yield.

POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS

The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroary; and X is C(R4)2, O, NR4, S, S(R4), or S(R4)2.

PIPERIDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.