117861-38-8

Basic information

• Product Name: N-Boc-2-azidoethylaMine
• Synonyms: N-Boc-2-azidoethylaMine;tert-Butyl n-(2-azidoethyl)carbamate
• CAS NO: 117861-38-8
• Molecular Formula: C₇H₁₄N₄O₂
• Molecular Weight: 186.21166
• Mol File: 117861-38-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Boc-2-azidoethylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-2-azidoethylaMine(117861-38-8)
• EPA Substance Registry System: N-Boc-2-azidoethylaMine(117861-38-8)

Safety Data

• Hazardous Substances Data: 117861-38-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
N-Boc-2-azidoethylamine is used as a building block for the synthesis of various pharmaceuticals and complex molecules, contributing to the development of new drugs and therapeutic agents.
Used in Peptide Synthesis:
N-Boc-2-azidoethylaMine is utilized in the synthesis of peptides, playing a crucial role in the formation of peptide bonds and the construction of peptide-based therapeutics.
Used in Bioconjugation:
N-Boc-2-azidoethylamine is employed as a linker in the formation of bioconjugates, enabling the attachment of biologically active molecules to other entities for various applications, such as drug delivery and imaging.
Used in Biomolecule Labeling and Modification:
N-Boc-2-azidoethylaMine serves as a tool for the labeling and modification of biomolecules, allowing researchers to study their structure, function, and interactions with other molecules.
Used in Click Chemistry Reactions:
Due to its azide functionality, N-Boc-2-azidoethylamine is often used in click chemistry reactions for the modification of biomolecules and materials, facilitating the rapid and efficient formation of new compounds and conjugates.

Upstream product

• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 
• 96628-67-0 2-(tert-butoxycarbonylamino)ethyl methanesulfonate 
• 57260-73-8 N-BOC-1,2-diaminoethane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 39684-80-5 2-(tert-butoxycarbonylamino)ethyl bromide 
• 1972-28-7 diethylazodicarboxylate 
• 158690-56-3 2-(tert-butoxycarbonylamino)ethyl-4-methylbenzenesulfonate 
• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 87156-40-9 1-amino-2-azidoethane 

Downstream Products

• 79513-35-2 N-(tert-butyloxycarbonyl)-1,2-ethanediamine hydrochloride 
• 1195110-38-3 {2-[4-(4-{5-[5-(4-hydroxyphenyl)-3-phenyl-7H-pyrrol-2-ylimino]-4-phenyl-5H-pyrrol-2-yl}-phenoxymethyl)-[l,2,3]triazol-l-yl]ethyl}carbamic acid t-butyl ester, BF₂ chelate 
• 1047626-95-8 N,N'-di-Boc-di-(azidoethyl)-p-xylylenediamine 
• 87156-40-9 1-amino-2-azidoethane 
• 1369825-28-4 C₃₆H₃₈N₄O₁₀ 
• 1172596-96-1 methyl (S)-2-(3-(2-(tert-butoxycarbonyl)aminoethyl)thioureido)-3-phenylpropanoate 

Relevant articles and documents

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Novel JAK1-selective benzimidazole inhibitors with enhanced membrane permeability

The previously identified Janus kinase 1 (JAK1)-selective inhibitor, 1-(2-aminoethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxamide (2), suffered from low cell permeability, which resulted in poor pharmacokinetic properties. In this study, by introducing less polar hydrogen bond donors at N1(a hydroxyalkyl or a methylaminoalkyl group) and C2 (a cyclohexanol group) positions, a series of novel benzimidazole derivatives were prepared, which exhibited selective JAK1 inhibitory activity (IC50against JAK1?=?0.08–0.15?μM; JAK1-selectivity?=?26–40 fold vs JAK2, 12–23 fold vs JAK3, and 38–54 fold vs Tyk2) along with significantly increased lipophilicity (3.3–15.8 times) as well as membrane permeability (6.3–12 times).

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Attractive Interactions between Heteroallenes and the Cucurbituril Portal

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BETA-LACTAMASE INHIBITORS

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