117896-99-8Relevant articles and documents
A Dual-Modal Molecular Probe for Near-Infrared Fluorescence and Photoacoustic Imaging of Peroxynitrite
Zhang, Jianjian,Zhen, Xu,Zeng, Jianfeng,Pu, Kanyi
, p. 9301 - 9307 (2018)
Peroxynitrite (ONOO-), a reactive and short-lived biological oxidant, is closely related with many pathological conditions such as cancer. However, real-time in vivo imaging of ONOO- in tumors remains to be challenging. Herein, we de
Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis
Cheng, Penghui,Zhang, Jianjian,Huang, Jiaguo,Miao, Qingqing,Xu, Chenjie,Pu, Kanyi
, p. 6340 - 6347 (2018/08/12)
Development of molecular probes for the detection of reactive oxygen and nitrogen species (RONS) is important for the pathology and diagnosis of diseases. Although an abnormally high RONS level has been identified in keloids-a benign dermal tumour develop
Trifluoromethyl ketone analogs as selective cPLA2 inhibitors
-
, (2008/06/13)
Selective inhibitors of the cPLA2enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where (R′), p, D, Y, Z, Ra, Rband A are as defined in the specification.
Trifluoromethyl ketone analogs as selective cPLA2 inhibitors
-
, (2008/06/13)
Selective inhibitors of the cPLA2enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula
Regioselective intramolecular oxidation of phenols and anisoles by dioxiranes generated in situ
Yang, Dan,Wong, Man-Kin,Yan, Zheng
, p. 4179 - 4184 (2007/10/03)
A novel method for regioselective oxidation of phenols and anisoles has been developed in which dioxiranes, generated in situ from ketones and Ozone, oxidize phenol derivatives in an intramolecular fashion. A series of ketones with electron-withdrawing groups, such as CF3, COOMe, and CH2Cl, were attached to phenols, anisoles, or aryl rings via a C2 or C3 methylene linker. In a homogeneous solvent system of CH3CN and H2O, oxidation of phenol derivatives 1-10 afforded spiro 2-hydroxydienones in 24-55% yields regardless of the presence of other substituents (ortho Me, meta Me or Br) on the aryl ring and the length of the linker. Experimental evidences were provided to support the mechanism that involves a regioselective π bond epoxidation of aryl rings followed by epoxide rearrangement and hemiketal formation.
Fluoroketone enzyme inhibitors
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, (2008/06/13)
A method for enzyme immunoassay for a ligand suspected to be present in a liquid sample includes signal amplification by use of at least two enzymes and a blocked modulator for one of the enzymes. Ligand present in the liquid binds to an antiligand and an