- Preparation method of distearoyl phosphatidylethanolamine
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The invention provides a preparation method of distearoyl phosphatidylethanolamine, wherein the preparation method comprises the following steps: (1) under alkaline conditions, carrying out amino protection reaction on glyceryl phosphatidylethanolamine represented by a formula (II) and a compound containing an amino protection group to obtain an intermediate a represented by a formula (III); (2) under the action of a catalyst, carrying out acylation reaction on the intermediate a and stearic anhydride to obtain an intermediate b represented by a formula (IV); and (3) under an acidic condition,carrying out an amino protection group removal reaction on the intermediate b to obtain distearoyl phosphatidylethanolamine represented by a formula (V), wherein R in the formula (III), the formula (IV) and the formula (V) represents an amino protection group. The preparation method is simple to operate, high in product yield and easy for industrial production.
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Paragraph 0057; 0082-0087
(2021/03/30)
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- Glycerol phosphatidylethanolamine and water-phase synthesis method thereof
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The invention provides glycerol phosphatidylethanolamine and a water-phase synthesis method thereof and relates to the glycerol phosphatidylethanolamine. The water-phase synthesis method comprises thefollowing steps: dissolving 1 equivalent weight of 1,3-cycloglycerophosphate into water; then adding ethanolamine; then adding an acidic reagent and adjusting the pH (Potential of Hydrogen) to be nomore than 11.0; after reacting, carrying out preparation column chromatographic separation and purification to obtain the glycerol phosphatidylethanolamine, wherein the glycerol phosphatidylethanolamine is faint yellow oil. Reaction is carried out in a water solution, and various groups of the ethanolamine and glycerol do not need to be protected; the water-phase synthesis method has the advantages of simple steps, greenness, environment friendliness and no pollution and high yield; needed raw materials are cheap and easy to obtain, the technology is simple and safe to operate and reaction equipment is simple.
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Paragraph 0035; 0037; 0038
(2018/09/21)
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- BIOPASSIVATING MEMBRANE STABILIZATION BY MEANS OF NITROCARBOXYLIC ACID-CONTAINING PHOSPHOLIPIDS IN PREPARATIONS AND COATINGS
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The present invention relates to nitro-carboxylic acid (s)-containing phospholipids, to be used for coating of medical devices such as stents, catheter balloons, wound pads or surgical suture material and for bio-passivating compositions, such as rinses, waterproofing solutions, coating solutions, cryoprotection solutions, cold preservation media, lyoprotection solutions, contrast media solutions, preservation and reperfusion solutions containing these compounds as well as preparing solutions thereof and coating medical devices as well as their uses.
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- Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate
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A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4-biphosphate (PI-3,4-P2) but does not cross-react with structurally similar phospholipid antigens is advantageous for PI-3,4-P2-specific immunoassay. The gene in the variable regions of the monoclonal antibody has been identified, which enables producing recombinant antibodies.
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- Monoclonal antibody recognizing phosphatidylinositol-3,4,5-triphosphate
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A monoclonal antibody that specifically recognizes phosphatidylinositol-3,4,5-triphosphate (PIP3) but does not cross-react with structurally similar phospholipid antigens is advantageous for PIP3-specific immunoassay. The gene in the variable regions of the monoclonal antibody has been identified, which enables producing recombinant antibodies.
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- N-acylphosphatidylethanolamines as anti-oxidants
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A method of inhibiting oxidation of products containing unsaturated fatty acids and their derivatives comprises treating the unsaturated fatty acids and their derivatives with N-acylphosphatidylethanolamines. Preferred N-acylphosphatidylethanolamines are N-acetylphosphatidylethanolamine and N-oleoylphosphatidylethanolamine.
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- Phosphorylated Sugars. Part 23. Synthesis and Reactions of Phosphodiesters containing 2-Aminoethanol and a Polyfunctional Alcohol and their Behaviour during Acid- and Base-catalysed Hydrolysis
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Phosphodiesters of 2-aminoethanol and of polyhydroxylated alcohols and sugars have been synthesised; their behaviour in M-HCl and in saturated (ca. 0.2 M) Ba(OH)2 solutions at 100 deg C have been examined.With the exception of 2-aminoethyl ethyl phosphate which, in acidic medium, yielded 2-aminoethylphosphate, free 2-aminoethanol and phosphorylated polyols or sugars were the main products formed.Because of simultaneously and/or sequentially occurring reactions the structures of the phosphorylated derivatives formed gave no unambiguous information regarding the structure of the initial phosphodiester.
- Trigalo, Francois,Szabo, Ladislas
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p. 1733 - 1744
(2007/10/02)
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