119584-75-7 Usage
Uses
Used in Pharmaceutical Research:
5-Bromo-quinazoline-2,4-diamine is utilized as a key intermediate in the synthesis of various heterocyclic compounds, which are essential for the development of innovative pharmaceutical agents. Its ability to modulate enzyme and receptor activities makes it a valuable building block in medicinal chemistry.
Used in Cancer Treatment Development:
In the field of oncology, 5-Bromo-quinazoline-2,4-diamine is employed as a potential therapeutic agent for the treatment of cancer. Its capacity to inhibit specific biological targets involved in cancer progression suggests its use in creating drugs that can combat the disease more effectively.
Used in Medicinal Chemistry for Enzyme and Receptor Inhibition:
5-Bromo-quinazoline-2,4-diamine serves as a chemical tool in medicinal chemistry, where it is used to explore and understand the interactions between enzymes and receptors. This knowledge is crucial for designing drugs that can precisely target these biological entities, leading to more effective treatments.
Used in the Synthesis of Heterocyclic Compounds:
5-Bromo-quinazoline-2,4-diamine is also used as a precursor in the synthesis of heterocyclic compounds, which are vital in various scientific and industrial applications. The versatility of 5-Bromo-quinazoline-2,4-diamine in forming diverse chemical structures underscores its importance in the creation of new materials and compounds.
Overall, 5-Bromo-quinazoline-2,4-diamine is a multifaceted chemical entity with broad applications across different sectors of pharmaceutical research and development, making it an indispensable component in the advancement of modern medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 119584-75-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,5,8 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 119584-75:
(8*1)+(7*1)+(6*9)+(5*5)+(4*8)+(3*4)+(2*7)+(1*5)=157
157 % 10 = 7
So 119584-75-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H7BrN4/c9-4-2-1-3-5-6(4)7(10)13-8(11)12-5/h1-3H,(H4,10,11,12,13)
119584-75-7Relevant articles and documents
Antifolate and Antibacterial Activities of 5-Substituted 2,4-Diaminoquinazolines
Harris, Neil V.,Smith, Christopher,Bowden, Keith
, p. 434 - 444 (2007/10/02)
A series of 5-substituted 2,4-diaminoquinazolines (3) has been synthesized and evaluated as inhibitors of the enzyme dihydrofolate reductase (DHFR) from both bacterial and mammalian sources.The best compounds (e.g. 53) show good activity against Escherichia coli DHFR, but there is no significant selectivity for the bacterial over the mammalian enzyme.The structure-activity relationships for enzyme inhibition appear to be complex and not amenable to simple analysis; a hypotesis to explain the observed qualitative structure-activity relationships is proposed.The inhibitory activities of the compounds against the growth of intact bacterial cells in vitro closely parallel those for the inhibition of the isolated bacterial enzymes, suggesting that their antifolate action is responsible for their antibacterial effects.Five of the compounds were tested for their ability to cure a systemic E. coli infection in the mouse, but they showed no therapeutic effects at their maximum tolerated doses.
Direct Synthesis of 2,4-Diaminoquinazolines from 2-Fluorobenzonitriles
Hynes, John B.,Pathak, Alpana,Panos, Constantina H.,Okeke, Claudia C.
, p. 1173 - 1177 (2007/10/02)
In a search for new methods for preparing 2,4-diaminoquinazolines having a diversity of substituents in the benzenoid ring, it was found that the reaction of 2,6-difluorbenzonitrile with guanidine carbonate gave 2,4-diamino-5-fluoroquinazoline in excellent yield.Extension of this approach to other 2-fluorobenzonitriles, some of which were elaborated for the first time, showed that this reaction possesses considerable generality.The cyclization was sucessful even when electron donating groups were present at position six.Only in two cases where a primary or secondary amino group was also present ortho to the cyano group was this transformation unsucessful.
