121064-15-1Relevant articles and documents
A new approach to synthesis of 3,3-dialkyl-3,4-dihydroisoquinoline derivatives
Shklyaev,Yeltsov,Rozhkova,Tolstikov,Dembitsky
, p. 486 - 493 (2007/10/03)
The synthesis of 3,3-dialkyl-3,4-dihydroisoquinolines via heterocyclization in three-component reaction of an activated arene with isobutyraldehyde and nitriles is described.
Three-component synthesis of 3,4-dihydroisoquinoline derivatives
Shklyaev, Yu. V.,Nifontov, Yu. V.
, p. 844 - 849 (2007/10/03)
A simple and convenient method for the synthesis of 1-substituted 3,3-dimethyl-3,4-dihydroisoquinolines was developed. The method is based on the [2+2+2] cyclization of alkyl- or alkoxybenzenes with isobutyraldehyde and nitriles.
Oxiranes in the Ritter reaction. Synthesis of 6,7- and 5,8-dimethoxy-3,3-dialkyl-3,4-dihydroisoquinolines by a tandem alkylation-cyclization reaction
Glushkov,Shurov,Maiorova,Postanogova,Feshina,Shklyaev
, p. 444 - 452 (2007/10/03)
The interaction of 1,2- or 1,4-dimethoxybenzene with isobutylene oxide and nitriles RCN leads to 1-R-6,7- or 1-R-5,8-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolines. In the case of 1,2-dimethoxybenzene and cyclohexene oxide the similar reaction is accompa