121912-29-6

Basic information

• Product Name: 3,4,5,6-TETRAHYDRO-2H-[1,4']BIPYRIDINYL-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 3,4,5,6-TETRAHYDRO-2H-[1,4']BIPYRIDINYL-4-CARBOXYLIC ACID ETHYL ESTER;Ethyl 1-(4-pyridinyl)piperidine-4-carboxylate;4-Piperidinecarboxylic acid, 1-(4-pyridinyl)-, ethyl ester;Ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate
• CAS NO: 121912-29-6
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.29
• Mol File: 121912-29-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3,4,5,6-TETRAHYDRO-2H-[1,4']BIPYRIDINYL-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5,6-TETRAHYDRO-2H-[1,4']BIPYRIDINYL-4-CARBOXYLIC ACID ETHYL ESTER(121912-29-6)
• EPA Substance Registry System: 3,4,5,6-TETRAHYDRO-2H-[1,4']BIPYRIDINYL-4-CARBOXYLIC ACID ETHYL ESTER(121912-29-6)

Safety Data

• Hazardous Substances Data: 121912-29-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs with potential medicinal properties. Its versatile molecular structure allows for the creation of compounds with anti-inflammatory and anti-cancer activities, making it a promising candidate for therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester is employed as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the synthesis of compounds that can effectively control pests and weeds, thereby enhancing crop protection and yield.
Used in Coordination Chemistry:
3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester is used as a ligand in coordination chemistry, where it forms complexes with metal ions. These complexes have potential applications in various fields, such as catalysis, sensing, and materials science, due to their unique electronic and structural properties.
Used in Organic Synthesis:
As a catalyst in organic reactions, 3,4,5,6-Tetrahydro-2H-[1,4']bipyridinyl-4-carboxylic acid ethyl ester facilitates the synthesis of a wide range of organic compounds. Its ability to accelerate reaction rates and improve product yields makes it a valuable tool in the development of new chemical products and processes.

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 64-17-5 ethanol 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 93913-86-1 4-carboxy-N-(4'-pyridino) piperidine 

Downstream Products

• 832088-74-1 benzyl 7-[4-ethoxycarbonyl-1-(pyridin-4-yl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinolin-2-carboxylate 
• 219491-86-8 N₁-[[1-(4-pyridyl)piperidin-4-yl]methoxycarbonyl]-1,2-benzenediamine 
• 219491-85-7 2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine 
• 219492-87-2 N₁-[1-(pyridin-4-yl)piperidin-4-ylmethylaminocarbonyl)-1,2-benzenediamine 
• 219492-86-1 2-[1-(pyridin-4-yl)piperidin-4-ylmethylaminocarbonyl]amino-nitrobenzene 
• 210962-09-7 1-(pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride 
• 1203600-35-4 C₂₁H₂₆N₂O₃ 
• 1203600-34-3 4-[(benzyloxy)methyl]-1-(pyridin-4-yl)piperidine-4-carboxylic acid 
• 1203600-36-5 tert-butyl 7-[({4-[(benzyloxy)methyl]-1-(pyridin-4-yl)piperidin-4-yl}carbonyl)oxy]-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 93913-86-1 4-carboxy-N-(4'-pyridino) piperidine 
• 130658-67-2 4-hydroxymethyl-1-(pyridin-4-yl)piperidine 

Relevant articles and documents

POLYMER BOUND 4-DIALKYLAMINO PYRIDINES: SYNTHESYS, CHARACTERIZATION AND CATALYTIC EFFICIENCY.

This work describes the synthesis of 4-carboxy-N-(4'-pyridino) piperidine (CPP), a functionalized analogue of the 4-dialkylamino pyridines, and its anchorage to various polymers by means of an amide bond.Some methods of titration of these supported CPP are pointed out.The efficiency of various supported CPP in the acetylation reaction of 1-methyl cyclohexanol are compared with DMAP as standard.The influence of various factors (polymer type, spacer, loading and temperature) are interpreted in relation to the nature of the microenvironment.An important decrease of the apparent pK of supported CPP as compared to DMAP (about 2 pK units) is assessed.

CATALYSEURS D'ACYLATION SUPPORTES: SYNTHESE ET ACTIVITE D'AMINO-4 PYRIDINES FIXEES SUR POLYMERES

New polystyrene-supported 4-amino pyridines are described.Some of them exhibit a good catalytic activity in acylation reactions.

Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity

The design and synthesis of a new class of nonpeptide direct thrombin inhibitors, built on the structure of 1-(pyridin-4-yl)piperidine-4-carboxamide, are described. Starting from a strongly basic 1-amidinopiperidine derivative (6) showing poor thrombin (fIIa) and factor Xa (fXa) inhibition activities, anti-fIIa activity and artificial membrane permeability were considerably improved by optimizing the basic P1 and the X-substituted phenyl P4 binding moieties. Structure-activity relationship studies, usefully complemented with molecular modeling results, led us to identify compound 13b, which showed excellent fIIa inhibition (Ki = 6 nM), weak anti-Xa activity (K i = 5.64 μM), and remarkable selectivity over other serine proteases (e.g., trypsin). Compound 13b showed in vitro anticoagulant activity in the low micromolar range and significant membrane permeability. In mice (ex vivo), 13b demonstrated anticoagulant effects at 2 h after oral dosing (100 mg·kg-1), with a significant 43% prolongation of the activated partial thromboplastin time (aPTT), over controls (P 0.05).

AMIDINE DERIVATIVE

Provision of a novel amidine derivative or a pharmaceutically acceptable salt thereof having an activated blood coagulation factor X-inhibitory activity. A compound represented by the formula (I) wherein each symbol is as defined above, or a pharmaceutically acceptable salt thereof.

Investigation of factor Xa inhibitors containing non-amidine S1 elements

Several non-amidino S1 derivatives of the 1,2-diaminobenzene-based scaffold (4) were synthesized and evaluated for their ability to bind to the active site and inhibit the human protease factor Xa. A subset of these compounds were also evaluated for their

BENZAMIDINE DERIVATIVES

A benzamidine derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an effect of inhibiting the blood coagulation based on their excellent effect of inhibiting activated blood-coagulation factor X. Thus, a blood-coagulation inhibitor or an agent for preventing or treating thrombosis or embolism, containing one of those compounds as the active ingredient, is provided.

Benzamidine derivatives

Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.

AMINOISOQUINOLINE DERIVATIVES

Aminoisoquinoline derivatives represented by formulae (I and II), analogs thereof or pharmaceutically acceptable salts of the same. Because of having excellent inhibitory effects on activated blood coagulation factor X, these compounds are useful as active ingredients in anticoagulants or preventives/remedies for thrombosis or embolism.

BENZAMIDINE DERIVATIVES

Benzamidine derivatives of the following formulae or analogs thereof, i. e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants.