122455-36-1

Basic information

• Product Name: 2-IODO-3-FLUORONITROBENZENE
• Synonyms: 1-fluoro-2-iodo-3-nitrobenzene;Benzene, 1-fluoro-2-iodo-3-nitro-
• CAS NO: 122455-36-1
• Molecular Formula: C₆H₃FINO₂
• Molecular Weight: 266.92
• Mol File: 122455-36-1.mol

Chemical Properties

• Boiling Point: 283.136 °C at 760 mmHg
• Flash Point: 125.036 °C
• Appearance: /
• Density: 2.093 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-IODO-3-FLUORONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODO-3-FLUORONITROBENZENE(122455-36-1)
• EPA Substance Registry System: 2-IODO-3-FLUORONITROBENZENE(122455-36-1)

Safety Data

• Hazardous Substances Data: 122455-36-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-IODO-3-FLUORONITROBENZENE is used as a key intermediate in the synthesis of various pharmaceuticals. Its ability to introduce iodine and fluorine atoms into aromatic compounds contributes to the development of new drugs with improved therapeutic properties and enhanced pharmacokinetics.
Used in Agrochemical Industry:
In the agrochemical sector, 2-IODO-3-FLUORONITROBENZENE is utilized as an intermediate for the production of agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, leading to increased agricultural productivity.
Used in Dye and Pigment Manufacturing:
2-IODO-3-FLUORONITROBENZENE is employed as a raw material in the manufacturing of dyes and pigments. Its unique properties allow for the creation of vibrant and stable colorants used in various industries, including textiles, plastics, and printing inks.
Used in Specialty Chemicals Production:
This chemical compound is also used in the production of specialty chemicals, such as those used in the manufacture of high-performance materials, coatings, and adhesives. Its presence in these products can improve their performance characteristics, such as durability, resistance to environmental factors, and adherence properties.
Safety Considerations:
Due to its potential for causing skin and eye irritation, as well as being harmful if inhaled or ingested, 2-IODO-3-FLUORONITROBENZENE is classified as a hazardous substance. It requires careful handling and storage to prevent accidents and exposure, ensuring the safety of workers and the environment.

InChI:InChI=1/C6H3FINO2/c7-4-2-1-3-5(6(4)8)9(10)11/h1-3H

Upstream product

• 10394-64-6 3-nitro-5-iodoaniline 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 122455-35-0 2-fluoro-6-nitrophenyl trifluoromethanesulfonate 
• 402-67-5 3-fluoro-1-nitrobenzene 

Downstream Products

• 122455-37-2 2-Iodo-3-fluoroaniline hydrochloride 
• 706752-99-0 3-fluoro-2-iodoaniline 

Relevant articles and documents

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Compounds and Uses Thereof

This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of anxiety disorders, cognitive disorders, and/or mood disorders.

STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

Steroid receptor modulator compounds and methods

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.