122710-21-8

Basic information

• Product Name: Ethanone, 1-(2-amino-4-methylphenyl)- (9CI)
• Synonyms: Ethanone, 1-(2-amino-4-methylphenyl)- (9CI);1-(2-AMino-4-Methylphenyl)ethanone;Ethanone, 1-(2-aMino-4-Methylphenyl)-;1-(2-Amino-4-methylphenyl);1-(2-amino-4-methylphenyl)ethan-1-one
• CAS NO: 122710-21-8
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Product Categories: ACETYLGROUP
• Mol File: 122710-21-8.mol

Chemical Properties

• Melting Point: 55-56 °C
• Boiling Point: 165 °C(Press: 15 Torr)
• Appearance: /
• Density: 1.069±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.43±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(2-amino-4-methylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-amino-4-methylphenyl)- (9CI)(122710-21-8)
• EPA Substance Registry System: Ethanone, 1-(2-amino-4-methylphenyl)- (9CI)(122710-21-8)

Safety Data

• Hazardous Substances Data: 122710-21-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(2-amino-4-methylphenyl)(9CI) is used as an intermediate compound for the synthesis of various pharmaceuticals. Its reactivity and structural features make it a valuable component in the development of new drugs.
Used in Dye Production:
In the dye industry, Ethanone, 1-(2-amino-4-methylphenyl)(9CI) is used as a key ingredient in the production of dyes. Its chemical properties allow for the creation of a wide range of colors and hues.
Used in Polymer and Plastics Industry:
Ethanone, 1-(2-amino-4-methylphenyl)(9CI) is employed as a monomer or a component in the synthesis of polymers and plastics. Its incorporation into these materials can enhance their properties, such as strength, flexibility, and durability.

Upstream product

• 537-92-8 3-Methylacetanilide 
• 155694-84-1 1-(4-methyl-2-nitrophenyl)ethan-1-one 
• 917-54-4 methyllithium 
• 2305-36-4 4-methylanthranilic acid 
• 1438400-27-1 N-(2-acetyl-5-methylphenyl)-4-methylbenzenesulfonamide 
• 75-16-1 methylmagnesium bromide 
• 26830-96-6 5-methyl-2-cyanoaniline 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 1193731-74-6 (S)-3,6-dimethylisobenzofuran-1(3H)-one 
• 1363508-20-6 C₁₀H₁₁NO 
• 64113-87-7 2-acetyl-5-methylbenzonitrile 
• 68674-72-6 4,7-dimethyl-2-phenylquinazoline 
• 52107-83-2 2’-iodo-4’-methylacetophenone 

Relevant articles and documents

AZABICYCLIC(THIO)AMIDES AS FUNGICIDAL COMPOUNDS

The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds

Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks

Described herein is an unusual Cp*CyRh(III)-catalyzed intramolecular site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams with broad substrate/functional group tolerance. Experimental and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.

Iodolopyrazolium Salts: Synthesis, Derivatizations, and Applications

The synthesis of iodolopyrazolium triflates via an oxidative cyclization of 3-(2-iodophenyl)-1H-pyrazoles is described. The reaction is characterized by a broad substrate scope, and various applications of these novel cyclic iodolium salts acting as useful synthetic intermediates are demonstrated, in particular in site-selective ring openings. This was finally applied to generate derivatives of the anti-inflammatory drug celecoxib. Their application as highly active halogen-bond donors is shown as well.

Gold-catalyzed cyclization of 1-(2′-Azidoaryl) propynols: Synthesis of polysubstituted 4-quinolones

An unprecedented gold-catalyzed procedure for the synthesis of polysubstituted 4-quinolones from 1-(2′-Azidoaryl) propynols is described. The reaction undergoes an intramolecular nucleophilic attack of the azide group to the Au-Activated triple bonds in a 6-endo-dig manner and subsequent gold-Assisted expulsion of N2 to furnish an α-imino gold carbene intermediate, which triggers a 1,2-carbon migration and finally is converted to 2,3-disubstituted 4-quinolone.

Water-Soluble Hypervalent Iodine(III) Having an I-N Bond. A Reagent for the Synthesis of Indoles

A readily accessible and bench-stable water-soluble hypervalent iodine(III) reagent (phenyliodonio)sulfamate (PISA) with an I-N bond was synthesized, and its structure was characterized by X-ray crystallography. With PISA, various indoles were synthesized via C-H amination of 2-alkenylanilines involving an aryl migration/intramolecular cyclization cascade with excellent regioselectivity in aqueous CH3CN. Notably, using this new method as the key step, not only two drug molecules, indometacin and zidometacin, but also another bioactive molecule, pravadoline, were synthesized.

Direct Electrophilic C?H Alkynylation of Unprotected 2-Vinylanilines

Unprotected aromatic amines can be used as directing groups in metal-catalyzed C?H alkynylations of alkenes. By using low amounts of an IrIIIcatalyst in combination with alkynylbenziodoxolones as electrophilic alkyne-transfer reagents, highly desirable 1,3-enynes were isolated in excellent yields of up to 98 % with Z stereoselectivity. A broad substrate scope as well as the high synthetic utility of the 1,3-enynes render this new method an efficient approach for the synthesis of five- and six-membered heterocycles. Further derivatizations of the 1,3-enynes to highly substituted quinolines through AuI- and N-bromosuccinimide-mediated exo-dig cyclizations were demonstrated.

NH2-directed C-H alkenylation of 2-vinylanilines with vinylbenziodoxolones

The first directing-group-mediated C-H alkenylation with alkenyl-λ3-iodanes as electrophilic alkene-transfer reagents has been developed. The application of free aromatic amines as challenging but synthetically valuable directing groups in combination with an IrIII catalyst enabled the synthesis of highly desirable 1, 3- dienes in excellent yields of up to 98% with high to perfect (Z, E) stereoselectivity. A broad substrate scope and further synthetic modifications are demonstrated.

Ru(ii)-catalyzed intermolecular ortho-C-H amidation of aromatic ketones with sulfonyl azides

Ru(ii)-catalyzed intermolecular ortho-C-H amidation of weakly coordinating aromatic ketones with sulfonyl azides is reported. The developed reaction protocol can be extended to various substituted aromatic ketones to afford a wide range of desired C-N bond formation products in good yields.

Highly stereoselective chemoenzymatic synthesis of the 3 h -isobenzofuran skeleton. access to enantiopure 3-methylphthalides

A straightforward synthesis of (S)-3-methylphthalides has been developed, with the key asymmetric step being the bioreduction of 2-acetylbenzonitriles. Enzymatic processes have been found to be highly dependent on the pH value, with acidic conditions being required to avoid undesired side reactions. Baker's yeast was found to be the best biocatalyst acting in a highly stereoselective fashion. The simple treatment of the reaction crudes with aqueous HCl has provided access to enantiopure (S)-3-methylphthalides in moderate to excellent yields.

Substituted oxoazaheterocyclyl compounds

This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..