123106-21-8Relevant articles and documents
Novel Tn antigen-containing neoglycopeptides: synthesis and evaluation as anti tumor vaccines.
Cipolla, Laura,Rescigno, Maria,Leone, Antonella,Peri, Francesco,La Ferla, Barbara,Nicotra, Francesco
, p. 1639 - 1646 (2002)
The fully unprotected alpha-C-glycosyl analogue of N-acetylgalactosamine 9 was conjugated by a non-natural oxime bond to the segment peptides (328--340)OVA and (327--339)OVA, affording neoglycopeptides 1--2 and 3, having one or two sugar units, respective
Bioorthogonal oxime ligation of a Mo(CO)4(N-N) CO-releasing molecule (CORM) to a TGF β-binding peptide
Pfeiffer, Hendrik,Sowik, Thomas,Schatzschneider, Ulrich
supporting information, p. 17 - 24 (2013/06/27)
Carbon monoxide is now well-established as an endogenously produced gasotransmitter in humans. To utilizes its spectrum of biological activity for therapeutic purposes, solid storage forms such as metal carbonyl complexes have to be used for easy handling and targeted delivery to the body. Thus, in the present work, a [Mo(CO)4(bpyCH3,CHO)] complex with an aldehyde group in a peripheral position on the 2,2′-bipyridine (bpy) ligand was coupled to a bioactive transforming growth factor (TGF) β-targeting peptide N-terminally functionalized with aminoxy acetic acid using the bioorthogonal and catalyst-free oxime ligation. CO release studies with the myoglobin assay as well as UV/Vis and IR spectroscopy showed the molybdenum tetracarbonyl moiety to slowly liberate carbon monoxide upon incubation in buffer in the dark. In addition, photoactivation at 468 nm with a LED array resulted in a significantly accelerated release of carbon monoxide, thus establishing this peptide bioconjugate as a new photoactivatable CO-releasing molecule (PhotoCORM) with a red-shifted excitation wavelength for better tissue penetration.
NOVEL INDOLIC DERIVATIVES, THEIR PREPARATION PROCESSES AND THEIR USES IN PARTICULAR AS ANTIBACTERIALS
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Page/Page column 49, (2010/06/19)
The invention relates to the use of at least one compound of the formula (I), in which R and R3 are particularly a hydrogen atom, R1 is particularly a hydrogen atom or a methyl, ethyl or isobutyl mi group, R4, R5, R6 and R7 are independently a hydrogen atony, an alkoxyl group with 1 to 7 carbon atoms or a halogen atom, R2 is a hydrogen atom, an O? group or an OH group, B is an N-GP1 or NRc, group, GP1 being a Boc or Cbz group, and Rc is a hydrogen atom or a methyl or t-butyl group, for preparing a drug for treating conditions associated with bacterial infections, in particular for treating bacterial diseases.
Polymer supported synthesis of aminooxyalkylated oligonucleotides, and some applications in the fabrication of microarrays
Sethi,Patnaik,Kumar,Gandhi,Gupta,Kumar
experimental part, p. 5442 - 5450 (2009/12/06)
A new protocol has been described for solid phase preparation of 3′- and 5′-aminooxylalkylated oligonucleotides using commercially available reagents. This involves attachment of linker 4 either with an LCAA-CPG support via succinoylation followed by synt
A novel heterotrifunctional peptide-based cross-linking reagent for facile access to bioconjugates. Applications to peptide fluorescent labelling and immobilisation
Clavé, Guillaume,Boutal, Hervé,Hoang, Antoine,Perraut, Fran?ois,Volland, Hervé,Renard, Pierre-Yves,Romieu, Anthony
supporting information; experimental part, p. 3065 - 3078 (2009/02/03)
A convenient, versatile and straightforward synthesis of a novel heterotrifunctional peptide-based linker molecule is described. This generic bio-labelling reagent contains an amine-reactive N-hydroxysuccinimidyl carbamate moiety, an aldehyde/ketone-reactive aminooxy group and a thiol group with a propensity to form urea, oxime and thioether linkages respectively. The full chemical orthogonality between the free aminooxy and thiol functionalities was demonstrated through the preparation of a fluorescent reagent suitable for the selective staining of a carboxaldehyde-modified surface by means of oxime ligation. The absence of reactivity of these two functions toward the nucleophile-sensitive active carbamate was obtained by using temporary aminooxy- and thiol-protecting groups removable under mild conditions. The utility of the linker molecule to cross-link three different molecular partners has been illustrated by the preparation of fluorescent tripod-functionalised surfaces which may be useful in developing new peptide microarrays and related immunosensors.
Synthesis of methylketone containing nucleoside triphosphates for RNA labelling
Trevisiol,Defrancq,Lhomme,Laayoun,Cros
, p. 6501 - 6510 (2007/10/03)
The three nucleoside triphosphates 1, 2 and 3 bearing a linker with a terminal methylketone group were prepared for incorporation into RNA fragments and post-labelling by the fluorescein derivative 4 containing an aminooxy group. (C) 2000 Elsevier Science Ltd.
