20295-82-3Relevant academic research and scientific papers
PROCESS FOR PRODUCTION OF O-SUBSTITUTED HYDROXYLAMINES
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Page/Page column 4, (2008/06/13)
[Purpose] The purpose of the present invention is to provide a method for the production of O-substituted hydroxylamine compounds at a high yield by using industrially available starting material. [Solution method] Method for the production of O-substituted hydroxylamine compounds comprising a process of obtaining O-substituted hydroxylamine disulfonic acid alkali metal salts by reacting hydroxylamine disulfonic acid alkali metal salts with halides exemplified by alkylating agents (RX), and a process of hydrogenating the obtained O-substituted hydroxylamine disulfonic acid alkali metal salt.
Aminooxyamide tricyclic inhibitors of farnesyl-protein transferase
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, (2008/06/13)
Novel aminooxyamide tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
Process for producing aminooxyacetic acid salts
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, (2008/06/13)
A process for producing an aminooxyacetic acid salt comprises reacting benzhydroxamic acid of formula: STR1 (where R1 is a hydrogen atom, an alkyl group, an alkoxy group or a halogen atom) with a halogenoacetic acid of formula: (where X is an iodine, bromine or chlorine atom) in the presence of a metal hydroxide or a metal carbonate to form benzamidooxyacetic acid of formula (IV): STR2 and thereafter hydrolyzing the benzamidooxyacetic acid in the presence of a mineral acid to obtain an aminooxyacetic acid salt of formula:
