123158-76-9

Basic information

• Product Name: 3-chloro-5-iodonitrobenzene
• Synonyms: 3-chloro-5-iodonitrobenzene;1-chloro-3-iodo-5-nitrobenzene;Benzene, 1-chloro-3-iodo-5-nitro-
• CAS NO: 123158-76-9
• Molecular Formula: C₆H₃ClINO₂
• Molecular Weight: 283.45099
• Mol File: 123158-76-9.mol

Chemical Properties

• Melting Point: 70℃
• Boiling Point: 301 °C at 760 mmHg
• Flash Point: 135.8 °C
• Appearance: /
• Density: 2.094
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-chloro-5-iodonitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-5-iodonitrobenzene(123158-76-9)
• EPA Substance Registry System: 3-chloro-5-iodonitrobenzene(123158-76-9)

Safety Data

• Hazardous Substances Data: 123158-76-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-5-iodonitrobenzene serves as a key starting material in organic synthesis, particularly for the production of a range of pharmaceuticals. Its unique structure contributes to the development of new medications, enhancing the therapeutic options available for various health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Chloro-5-iodonitrobenzene is utilized as a precursor in the synthesis of various agrochemicals. Its role in creating effective pest control agents and other agricultural products underscores its importance in ensuring crop protection and yield enhancement.
Used in Dye Industry:
3-Chloro-5-iodonitrobenzene also finds application in the dye industry, where it is employed in the creation of different types of dyes. Its chemical composition allows for the production of dyes with specific color properties, catering to the needs of various industries that rely on coloring agents.
Used in Specialty Chemicals Manufacturing:
3-Chloro-5-iodonitrobenzene is further utilized in the manufacturing of specialty chemicals, which are tailored for specific applications and often possess unique performance characteristics. Its contribution to this field highlights its versatility and the breadth of its applicability in chemical engineering.
Used in Research Laboratories:
Due to its reactive nature and distinctive chemical attributes, 3-Chloro-5-iodonitrobenzene is also employed in research laboratories. It is used for studying various chemical reactions and processes, aiding in the advancement of scientific knowledge and the discovery of new chemical compounds and materials.

Upstream product

• 123158-75-8 2-amino-5-chloro-3-nitrophenyliodide 
• 861609-74-7 2-chloro-6-iodo-4-nitroaniline 
• 64-17-5 ethanol 
• 110-46-3 isopentyl nitrite 
• 89-63-4 4-Chloro-2-nitroaniline 
• 99-54-7 3,4-dichloronitrobenzene 
• 88-74-4 2-nitro-aniline 
• 121-87-9 2-Chloro-4-nitroaniline 
• 7664-93-9 sulfuric acid 
• 146512-91-6 5-nitro-4-chloro-2-iodoaniline 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 

Downstream Products

• 83171-49-7 3-chloro-5-iodoaniline 
• 62606-14-8 1-chloro-3-(methylsulfonyl)-5-nitrobenzene 
• 62605-99-6 3-chloro-5-(methylsulfonyl)aniline 

Relevant articles and documents

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Method for synthesizing m-iodonitrobenzene compound

Provided is a method for synthesizing m-iodonitrobenzene; in the presence of oxygen gas, a palladium catalyst, a copper additive, a bismuth reagent and potassium phosphate, an o-nitrobenzoic acid compound and metal iodide are subjected to a substitution reaction in an organic solvent to form a corresponding m-iodonitrobenzene compound, wherein a metal in the metal iodide is an alkali metal or an alkaline earth metal. The method has obvious advantages of cheap and easily obtained reaction raw materials (including o-nitrobenzoic acid and MI), small amount of the metal catalyst, minimum environmental pollution with oxygen gas as an oxidant, good tolerance on various functional groups on an aromatic ring and the like. The method can be widely applied in the fields of synthesis of drugs, materials, natural products and the like in industrial and academic circles.

Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders

4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment of neurodegenerative disorders. 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, other than carboxy or C 1-6 alkoxycarbonyl, are novel compounds, as also are compounds of formula II STR1 wherein R 2 represents carboxy or a group convertible thereto in vivo, R 6 is hydrogen and R 5 and R 7 represent C 1-6 alkyl or halogen, provided that R 5 and R 7 are not simultaneously chlorine or simultaneously bromine; a process for preparing the novel compounds is described, as also are pharmaceutical compositions containing the novel compounds.

Kynurenic Acid Derivatives. Structure-Activity Relationships for Excitatory Amino Acid Antagonism and Identification of Potent and Selective Antagonists at the Glycine Site of the N-Methyl-D-aspartate Receptor

Derivatives of the nonselective excitatory amino acid antagonist kynurenic acid (4-oxo-1,4-dihydroquinoline-2-carboxylic acid, 1) have been synthesized and evaluated for in vitro antagonist activity at the excitatory amino acid receptors sensitive to N-me