123158-77-0

Basic information

• Product Name: 2-Iodo-4-Methyl-6-nitro-phenylaMine
• Synonyms: 2-Iodo-4-Methyl-6-nitro-phenylaMine;2-Iodo-4-Methyl-6-nitroaniline;2-iodo-4-methyl-6-nitroBenzenamine
• CAS NO: 123158-77-0
• Molecular Formula: C₇H₇IN₂O₂
• Molecular Weight: 278.04715
• EINECS: -0
• Mol File: 123158-77-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Iodo-4-Methyl-6-nitro-phenylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-4-Methyl-6-nitro-phenylaMine(123158-77-0)
• EPA Substance Registry System: 2-Iodo-4-Methyl-6-nitro-phenylaMine(123158-77-0)

Safety Data

• Hazardous Substances Data: 123158-77-0(Hazardous Substances Data)

Upstream product

• 89-62-3 4-methyl-2-nitroaniline 
• 7790-99-0 Iodine monochloride 
• 64-19-7 acetic acid 
• 103-89-9 4-Methylacetanilide 
• 106-49-0 p-toluidine 
• 209459-11-0 methyl 2-aminobenzo[d]thiazole-7-carboxylate 

Downstream Products

• 123158-78-1 1-iodo-3-methyl-5-nitrobenzene 
• 1018958-42-3 1-[2-(2-amino-5-methyl-3-nitrophenylamino)phenyl]ethanone 
• 1180556-83-5 2-cyclohex-1-enyl-5-methyl-1H-indol-7-ylamine 
• 1120334-12-4 5-methyl-7-nitro-2-phenyl-1H-indole 
• 10553-09-0 5-methyl-7-nitro-1H-indole 
• 74586-54-2 3-iodo-5-methylaniline 
• 1120334-13-5 4-methyl-2-nitro-6-(2-phenylacetylene)phenylamine 

Relevant articles and documents

Phenanthridine-Containing Pincer-like Amido Complexes of Nickel, Palladium, and Platinum

Proligands based on bis(8-quinolinyl)amine (L1) were prepared containing one (L2) and two (L3) benzo-fused N-heterocyclic phenanthridinyl (3,4-benzoquinolinyl) units. Taken as a series, L1-L3 provides a ligand template for exploring systematic π-extension

TRICYCLIC HETEROARYL-SUBSTITUTED QUINOLINE AND AZAQUINOLINE COMPOUNDS AS PAR4 INHIBITORS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and R1, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

THERAPY AND PHARMACEUTICAL COMPOSITION

A novel class of compounds called perenosins, and their use in the treatment and/or prevention of cancer or a neoplastic condition.

Perenosins: A new class of anion transporter with anti-cancer activity

A new class of anion transporter named 'perenosins' consisting of a pyrrole linked through an imine to either an indole, benzimidazole or indazole is reported. The indole containing members of the perenosin family function as effective transmembrane Cl-/NO3- antiporters and HCl cotransporters in a manner similar to the prodigiosenes. The compounds reduce the viability of MDA-MB-231 and MCF-7.

As cell necrosis inhibitors of the indole compounds (by machine translation)

The invention relates to chemical formula (1) indole compounds, or its pharmaceutically acceptable salt or isomer, and in containing the same as the characteristic, as an active ingredient for the prevention or treatment of cell necrosis and its associated disease composition and method of manufacturing. (by machine translation)

INDOLE COMPOUND AS INHIBITOR OF NECROSIS

The present invention relates to an indole compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.

Indole and indazole compounds as an inhibitor of cellular necrosis

The present invention refers to a formula (1) compounds of, pharmaceutically acceptable salts or isomers thereof thereof, and characterized by by containing as active ingredients-associated diseases, cell death and method for the prevention or treatment of relates and compositions. [Formula 1] In formula said R 1, R 2, R 3, R 4, R 5, R 6, A, X, n and m to equal the specification.

INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT

The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.