1239319-82-4

Basic information

• Product Name: 2-AMino-7-Boc-7-azaspiro[...
• Synonyms: 2-AMino-7-Boc-7-azaspiro[...;2-AMino-7-Boc-7-azaspiro[3.5]nonane;2-AMino-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester;tert-Butyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate
• CAS NO: 1239319-82-4
• Molecular Formula: C₁₃H₂₄N₂O₂
• Molecular Weight: 240.34186
• Mol File: 1239319-82-4.mol

Chemical Properties

• Boiling Point: 336.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10?+-.0.20(Predicted)
• CAS DataBase Reference: 2-AMino-7-Boc-7-azaspiro[...(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-7-Boc-7-azaspiro[...(1239319-82-4)
• EPA Substance Registry System: 2-AMino-7-Boc-7-azaspiro[...(1239319-82-4)

Safety Data

• Hazardous Substances Data: 1239319-82-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-7-Boc-7-azaspiro[4.4]nonane is used as a building block for the synthesis of bioactive molecules due to its versatile chemical structure and the presence of an amino group and a Boc protecting group. This allows for the creation of a wide range of pharmaceutical compounds with potential therapeutic applications.
Used in Drug Discovery and Design:
2-Amino-7-Boc-7-azaspiro[4.4]nonane is utilized as a key component in drug discovery and design processes. Its unique spirocyclic scaffold and physicochemical properties make it a promising candidate for the development of new drugs with improved efficacy, selectivity, and pharmacokinetic profiles.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-Amino-7-Boc-7-azaspiro[4.4]nonane serves as a valuable research tool. Its structural features and potential biological activity make it an interesting subject for studying the relationship between molecular structure and pharmacological activity, ultimately aiding in the design of more effective therapeutic agents.

Upstream product

• 203661-69-2 tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 
• 1239320-24-1 tert-butyl 2-(hydroxyimino)-7-azaspiro[3.5]nonane-7-carboxylate 
• 614729-59-8 2-((methylsulfonyl)oxy)-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester 
• 1239319-81-3 2-azido-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester 
• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 
• 240401-28-9 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester 

Downstream Products

• 1313802-10-6 7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine 
• 1313802-09-3 (7-aza-spiro[3.5]non-2-yl)-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine 
• 1313732-59-0 7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine 
• 1313732-60-3 (7-aza-spiro[3.5]non-2-yl)-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1 ,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine 
• 1313732-91-0 (7-aza-spiro[3.5]non-2-yl)-[(S)-6,7-dimethyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine 
• 1313732-90-9 7-[(S)-6,7-dimethyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine 
• 1239319-83-5 tert-Butyl 2-(4-nitrophenoxycarbonylamino)-7-azaspiro[3.5]nonane-7-carboxylate 
• 1239319-64-2 3-carbamoylisoxazol-5-ylmethyl{7-[5-(4-fluorophenyl)pyridin-2-yl]-7-azaspiro[3.5]non-2-yl}carbamate 
• 1417838-14-2 C₂₆H₃₂F₃N₇O₂ 
• 1417838-02-8 C₂₆H₃₂F₃N₇O₂ 

Relevant articles and documents

1-azaspirocycle compound, and preparation method and applications thereof

The invention discloses a 1-azaspirocycle compound, and preparation method and applications thereof, and belongs to the field of pharmaceutical chemistry. The 1-azaspirocycle compound with a structurerepresented by formula I, or a pharmaceutically acceptable salt or a stereisomer or a solvate or a prodrug thereof is capable of realzing combination with Autotaxin, can be taken as an Autotaxin inhibitor, and can be used for prevention and treatment of diseases with Autotaxin expression increasing pathological characteristics such as cancer and fibrosis diseases especially pulmonary fibrosis andhepatic fibrosis, metabolic diseases, myelodysplastic syndrome, cardiovascular diseases, autoimmune diseases, inflammation, neurological diseasses, or pain. Compared with single component inhibitors,the 1-azaspirocycle compound and the derivatives possesses following advantages: blocking and interfacing at the upsteam of a plurality of key signal channels are realized, tumor cell growth and transfer are relieved or dalyed, early caused drug resistance is avoided, and novel means are provided for treatment of tumor cells.

DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

The invention relates to a compound of the general formula (I) in which R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, NR8R9 group; m, n, o and p are independently an integer equal to 0, 1, 2 or 3; A is a covalent bond or a C1-8-alkylene group; R1 is an optionally substituted aryl or heteroaryl group; R3 is a hydrogen or fluorine atom or a C1-6-alkyl group or a trifluoromethyl group; R4 is an optionally substituted 5-member heterocyclic compound; the compound being in the form of a base or acid addition salt. The invention also relates to the therapeutic use thereof.