124957-41-1

Basic information

• Product Name: methyl 2-[acetoxy(4-methoxyphenyl)methyl]acrylate
• Synonyms: methyl 2-[acetoxy(4-methoxyphenyl)methyl]acrylate
• CAS NO: 124957-41-1
• Molecular Weight: 264.278
• Mol File: 124957-41-1.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-[acetoxy(4-methoxyphenyl)methyl]acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[acetoxy(4-methoxyphenyl)methyl]acrylate(124957-41-1)
• EPA Substance Registry System: methyl 2-[acetoxy(4-methoxyphenyl)methyl]acrylate(124957-41-1)

Safety Data

• Hazardous Substances Data: 124957-41-1(Hazardous Substances Data)

Upstream product

• 115240-92-1 methyl 2-[hydroxy(4-methoxyphenyl)methyl]prop-2-enoate 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 148149-45-5 α-methyl-β-(p-methoxy-phenyl)-ethyl propionate 
• 17226-85-6 α,β-anti-methyl 3-hydroxy-2-methyl-3-(p-methoxyphenyl)propionate 
• 17226-85-6 α,β-syn-methyl 3-hydroxy-2-methyl-3-(p-methoxyphenyl)propionate 
• 671778-72-6 methyl (2Z)-3-(4'-methoxyphenyl)-2-chloromethylpropenoate 
• 126356-04-5 (E)-methyl 2-methyl-3-(p-methoxyphenyl)prop-2-enoate 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR PROTEIN LABELING, MODIFICATION, ANALYSIS, AND TARGETED DELIVERY

The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, delivery, probing and/or analytical measurements of small molecule drugs, proteins, antibodies and other biomolecules. The invention provides novel biologically active agents useful as diagnostics or therapeutics, and related composition and methods of uses thereof.

Organocatalyzed Decarboxylative Trichloromethylation of Morita–Baylis–Hillman Adducts in Batch and Continuous Flow

Two protocols for the organocatalyzed decarboxylative trichloromethylation of Morita–Baylis–Hillman (MBH) substrates have been developed. Applying sodium trichloroacetate, as the trichloromethyl anion precursor, in combination with an organocatalyst and a

Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophiles

The reactivity of Morita-Baylis-Hillman allyl acetates was employed to introduce phosphorus-containing functionalities to the side chain of the cinnamic acid conjugated system by nucleophilic displacement. The proximity of two acidic groups, the carboxyla

One-pot synthesis of allyl thioacetate from benzaldehydes and activated alkenes using the Morita-Baylis-Hillman reaction as a key step

An efficient, regioselective and steresoselecitive one-pot protocol for the synthesis of (Z)-S-2-alkoxycarbonyl-3-acylallyl ethanethioates and (E)-S-2-cyano-3-acylallyl ethanethioates from benzaldehydes and activated alkenes (methyl acrylate and acrylonit

N-bromosuccinimide-mediated radical cyclization of 3-arylallyl azides: Synthesis of 3-substituted quinolines

Visible light irradiation of N-bromosuccinimide serves as an effective means to convert methyl 2-(azidomethyl)-3-arylpropenoates and 2-(azidomethyl)-3-arylacrylonitriles to the corresponding iminyl radicals via ?±-hydrogen abstraction and subsequent extrusion of dinitrogen. Thus formed iminyl radicals then undergo intramolecular ortho attack on the aryl ring, affording methyl quin-oline-3-carboxylates and quinoline-3-carbonitriles respectively.

Pd-catalyzed decarboxylative allylic coupling of acetates of Baylis-Hillman alcohols with propiolic acids: A highly regio- and stereoselective synthesis of 1,5-diarylpent-1-en-4-yne derivatives

Pd-catalyzed decarboxylative allylic coupling of acetates of Baylis-Hillman alcohols with alkynyl carboxylic acids leading to the formation of an important class of 1,5-diarylpent-1-en-4-ynes in a highly regio- and stereoselective manner has been develope

Heterocycles from Morita-Baylis-Hillman adducts: Synthesis of 5-oxopyrazolidines, arylidene-5-oxopyrazolidines, and oxo-2,5-dihydro-pyrazols

Starting from Morita-Baylis-Hillman (MBH) adducts, an approach for the synthesis of oxopyrazolidines, arylidene-oxopyrazolidines, and oxo-2,5-dihydropyrazoles is described. The method is based on a tandem process involving a Michael addition of amino-guan

Iodine-mediated intramolecular electrophilic aromatic cyclization in allylamines: A general route to synthesis of quinolines, pyrazolo[4,3-b] pyridines, and thieno[3,2-b]pyridines

An unprecedented synthesis of aromatic ring annulated pyridines from suitably substituted primary allylamines via intramolecular electrophilic aromatic cyclization mediated by molecular iodine under mild conditions is described.

A general approach to the synthesis of β2-amino acid derivatives via highly efficient catalytic asymmetric hydrogenation of α-aminomethylacrylates

A new strategy was developed for the synthesis of a valuable class of α-aminomethylacrylates via the Baylis-Hillman reaction of different aldehydes with methyl acrylate followed by acetylation of the resulting allylic alcohols and SN2′-type amination of the allylic acetates. Asymmetric hydrogenation of these diverse olefinic precursors using rhodium(Et-Duphos) catalysts provided the corresponding β2-amino acid derivatives with excellent enantioselectivities and exceedingly high reactivities (up to >99.5% ee and S/C=10,000). The first hydrogenation of (Z)-configurated substrates was studied for the synthesis of β2-amino acid derivatives. The high influence of the substrate geometry and steric hindrance on the reactivity and enantioselectivity was also disclosed for this reaction. This protocol provides a highly practical, facile and scalable method for the preparation of optically pure β2- amino acids and their derivatives under mild reaction conditions.

Reaction of Baylis-Hillman adducts with fluorinated silanes

Reactions of acylated Baylis-Hillman adducts bearing nitrile, ester, or ketone groups with C6F5-substituted silicon reagents MenSi(C6F5)4-n (n = 1-3) have been studied. The reactions are in