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2-Pyridinecarbonyl chloride, 6-methyl- (9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 126125-54-0 Structure
  • Basic information

    1. Product Name: 2-Pyridinecarbonyl chloride, 6-methyl- (9CI)
    2. Synonyms: 2-Pyridinecarbonyl chloride, 6-methyl- (9CI)
    3. CAS NO:126125-54-0
    4. Molecular Formula: C7H6ClNO
    5. Molecular Weight: 155.58164
    6. EINECS: N/A
    7. Product Categories: ACIDHALIDE
    8. Mol File: 126125-54-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Pyridinecarbonyl chloride, 6-methyl- (9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Pyridinecarbonyl chloride, 6-methyl- (9CI)(126125-54-0)
    11. EPA Substance Registry System: 2-Pyridinecarbonyl chloride, 6-methyl- (9CI)(126125-54-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 126125-54-0(Hazardous Substances Data)

126125-54-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 126125-54-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,1,2 and 5 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 126125-54:
(8*1)+(7*2)+(6*6)+(5*1)+(4*2)+(3*5)+(2*5)+(1*4)=100
100 % 10 = 0
So 126125-54-0 is a valid CAS Registry Number.

126125-54-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-methylpyridine-2-carbonyl chloride

1.2 Other means of identification

Product number -
Other names 2-PYRIDINECARBONYL CHLORIDE,6-METHYL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:126125-54-0 SDS

126125-54-0Relevant articles and documents

Zn2+ and Cu2+ complexes of a fluorescent scorpiand-type oxadiazole azamacrocyclic ligand: Crystal structures, solution studies and optical properties

Ambrosi, Gianluca,Formica, Mauro,Fusi, Vieri,García-Espa?a, Enrique,Inclán, Mario,Paoli, Paola,Paz Clares, M.,Pont, Isabel,Ricci, Angela,Rossi, Patrizia

, p. 1897 - 1906 (2020)

A ligand comprised of a macrocyclic pyridinophane core having a pendant arm containing a secondary amine group linked through a methylene spacer to a pyridyl-oxadiazole-phenyl (PyPD) fluorescent system has been prepared (L). The crystal structures of [ZnL](ClO4)2 and [CuL](ClO4)2 show that M2+ is coordinated to all the nitrogen atoms of the macrocyclic core, the secondary amine of the pendant arm and the nitrogen atom of the pyridine group of the fluorescent moiety, the latter bond being clearly weaker than the one with the pyridine of the macrocycle. Solution studies showed the formation of a highly stable Cu2+ complex with 1 : 1 stoichiometry, whereas with Zn2+ least stable complexes were formed and, given the right conditions, a [Zn3L2]6+ species was also detected, but it was not possible to isolate this species in the solid state. Following Zn2+ coordination, a strong chelation-induced enhancement of fluorescence was observed, a behaviour that was not observed with any of the other metal cations tested.

Two-way linkage photoisomerization of [Ru(2,2':6',2''-terpyridine)(6- {(methylsulfinyl)methyl}picolinate)]BF4

Suzuki, Shoko,Sakamoto, Ryota,Nishihara, Hiroshi

, p. 17 - 18 (2013)

[Ru(tpy)(picSO)]BF4 (tpy: 2,2':6',2''-terpyridine, picSO: 6- [(methylsulfinyl)methyl]picolinate) undergoes profound linkage isomerization behavior between stable S-bound and metastable O-bound isomers. S-[RuII(tpy)(picSO)]BF4 experiences photoisomerization to O-[RuII(tpy)(picSO)] BF4 upon irradiation with 436nm light, whereas the back reaction is triggered with 546nm light. Electrochemical linkage isomerization also takes place.

A deep insight into polybenzoxazole formation in the heterocycle-containing polybenzoxazine: An enlightening thought for smarter precursor design

Liu, Jingkai,Cao, Lijun,Dai, Jinyue,Peng, Yunyan,Liu, Xiaoqing

, (2021)

When artificially introducing an ortho-amide group into benzoxazine monomer, the conversion of polybenzoxazine (PBZ) into polybenzoxazole (PBO) could happen at higher temperature. However, the mechanism investigation for this reaction is far from enough,

IRAK DEGRADERS AND USES THEREOF

-

Paragraph 00512; 00620-00622, (2021/06/26)

The present invention provides compounds, compositions thereof, and methods of using the same.

Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates

Chattopadhyay, Buddhadeb,Hassan, Mirja Md Mahamudul,Hoque, Md Emdadul

supporting information, p. 5022 - 5037 (2021/05/04)

Here we describe the discovery of a new class of C-H borylation catalysts and their use for regioselective C-H borylation of aromatic, heteroaromatic, and aliphatic systems. The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutral chelating ligands used in the standard C-H borylation conditions. It is reported that the employment of these newly discovered catalysts show excellent reactivity and ortho-selectivity for diverse classes of aromatic substrates with high isolated yields. Moreover, the catalysts proved to be efficient for a wide number of aliphatic substrates for selective C(sp3)-H bond borylations. Heterocyclic molecules are selectively borylated using the inherently elevated reactivity of the C-H bonds. A number of late-stage C-H functionalization have been described using the same catalysts. Furthermore, we show that one of the catalysts could be used even in open air for the C(sp2)-H and C(sp3)-H borylations enabling the method more general. Preliminary mechanistic studies suggest that the active catalytic intermediate is the Ir(bis)boryl complex, and the attached ligand acts as bidentate ligand. Collectively, this study underlines the discovery of new class of C-H borylation catalysts that should find wide application in the context of C-H functionalization chemistry.

IRAK DEGRADERS AND USES THEREOF

-

Paragraph 00920; 001678-001680, (2021/01/23)

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

NOVEL NUCLEOSIDE OR NUCLEOTIDE DERIVATIVES, AND USES THEREOF

-

Paragraph 0062, (2020/12/10)

The present disclosure relates to a novel nucleoside or nucleotide derivative, a racemate thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating viral infection-associated diseases, containing the same as an active ingredient.

Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis

Liu, Mingming,Liang, Yuru,Zhu, Zhongzhen,Wang, Jin,Cheng, Xingxing,Cheng, Jiayi,Xu, Binpeng,Li, Rong,Liu, Xinhua,Wang, Yang

, p. 9299 - 9314 (2019/10/16)

In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer metastasis treatment, 68 new aryl carboxamide compounds were synthesized and evaluated for their inhibitory effect by dual luciferase-reporter assay. Based on five rounds of investigation on structure-activity relationships step by step, compound 30m was discovered as the most active inhibitor (IC50 = 0.32 μM) with no obvious cytotoxicity (CC50 > 50 μM). It effectively attenuated hypoxia-induced HIF-1α protein accumulation and reduced transcription of vascular epidermal growth factor in a dose-dependent manner, which was further demonstrated by its inhibitory potency on capillary-like tube formation, angiogenesis of zebrafish as well as cellular migration and invasion. Importantly, compound 30m exhibited antimetastatic potency in breast cancer lung metastasis in the mice model, indicating its promising therapeutic potential for prevention and treatment of tumor metastasis. These results definitely merit attention for further rational design of more efficient HIF-1 inhibitors in the future.

Amide Effects in C?H Activation: Noncovalent Interactions with L-Shaped Ligand for meta Borylation of Aromatic Amides

Bisht, Ranjana,Hoque, Md Emdadul,Chattopadhyay, Buddhadeb

supporting information, p. 15762 - 15766 (2018/11/10)

A new concept for the meta-selective borylation of aromatic amides is described. It has been demonstrated that while esters gave para borylations, amides lead to meta borylations. For achieving high meta selectivity, an L-shaped bifunctional ligand has been employed and engages in an O???K noncovalent interaction with the oxygen atom of the moderately distorted amide carbonyl group. This interaction provides exceptional control for meta C?H activation/borylation.

Iridium(III)-Catalyzed Regioselective Intermolecular Unactivated Secondary Csp3?H Bond Amidation

Xiao, Xinsheng,Hou, Cheng,Zhang, Zhenhui,Ke, Zhuofeng,Lan, Jianyong,Jiang, Huanfeng,Zeng, Wei

supporting information, p. 11897 - 11901 (2016/11/16)

For the first time, a highly regioselective intermolecular sulfonylamidation unactivated secondary Csp3?H bond has been achieved using IrIIIcatalysts. The introduced N,N’-bichelating ligand plays a crucial role in enabling iridium–nitrene insertion into a secondary Csp3?H bond via an outer-sphere pathway. Mechanistic studies and density functional theory (DFT) calculations demonstrated that a two-electron concerted nitrene insertion was involved in this Csp3?H amidation process. This method tolerates a broad range of linear and branched-chain N-alkylamides, and provides efficient access to diverse γ-sulfonamido-substituted aliphatic amines.

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